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Synthesis 2009(15): 2517-2522  
DOI: 10.1055/s-0029-1216890
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Cu-Al Hydrotalcite: An Efficient and Reusable Ligand-Free Catalyst for the Coupling of Aryl Chlorides with Aliphatic, Aromatic, and N(H)-Heterocyclic Amines

B. Sreedhar*, R. Arundhathi, P. Linga Reddy, M. Amarnath Reddy, M. Lakshmi Kantam
Indian Institute of Chemical Technology, Inorganic & Physical Chemistry Division, Hyderabad 500007, India
Fax: +91(40)27160921; e-Mail: sreedharb@iict.res.in;
Further Information

Publication History

Received 11 March 2009
Publication Date:
10 July 2009 (online)

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Abstract

Copper-aluminum hydrotalcite catalysts were effectively used in the coupling of aryl chlorides with aliphatic, aromatic, and N(H)-heterocyclic amines to afford the corresponding N-alkylated/arylated amines in excellent yields. The catalyst was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity.

Key words

hydrotalcite - copper - aryl chloride - coupling - N-alkylated/arylated amines - reusable catalyst

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