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Synthesis 2009(8): 1336-1340  
DOI: 10.1055/s-0028-1088018
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Click Reactions with Nitroxides

Tamás Kálaia, Wayne L. Hubbellb, Kálmán Hideg*a
a Institute of Organic and Medicinal Chemistry, University of Pécs, P.O. Box 99, 7602 Pécs, Hungary
Fax: +36(72)536219; e-Mail: kalman.hideg@aok.pte.hu;
b Jules Stein Eye Institute and Department of Chemistry & Biochemistry, University of California Los Angeles, Los Angeles, CA 90095-1662, USA
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Publication History

Received 24 November 2008
Publication Date:
16 March 2009 (online)

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Abstract

Copper-catalyzed azide-alkyne 1,3-dipolar cycloadditions (CuAAC) with paramagnetic azide and alkyne building blocks are described. This method provides a route to the synthesis of complex spin-labeled molecules such as amino acids, carbohydrates, drug molecules and biradicals.

Key words

acetylenes - amino acids - azides - click chemistry - free radicals