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Synthesis 2008(22): 3649-3656  
DOI: 10.1055/s-0028-1083602
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Assisted Three-Component Reaction for the Synthesis of Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones

Fadime Mert-Balcia, Jürgen Conrada, Kathrin Meindlb, Thomas Schulzb, Dietmar Stalkeb, Uwe Beifuss*a
a Bioorganische Chemie, Institut für Chemie, Universität Hohenheim, Garbenstr. 30, 70599 Stuttgart, Germany
Fax: +49(711)45922951; e-Mail: ubeifuss@uni-hohenheim.de;
b Institut für Anorganische Chemie, Universität Göttingen, Tammannstr. 4, 37077 Göttingen, Germany
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Publication History

Received 30 April 2008
Publication Date:
29 October 2008 (online)

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Abstract

Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones can be obtained by a microwave-assisted three-component reaction between 2-aminopyridines, isocyanides, and 2-carboxybenzaldehydes under acidic conditions.

Key words

heterocycles - lactams - multicomponent reaction - Ugi reaction - isocyanides

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