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Hamostaseologie 2015; 35(04): 372-375
DOI: 10.5482/HAMO-15-04-0013
Review
Schattauer GmbH

Heparin induced thrombocytopenia

Contemporary therapeutic approaches in light of the new oral anticoagulantsHeparin-induzierte ThrombopenieZeitgemäße Therapien unter Berücksichtigung neuer Antikoagulanzien
E. A. Sanidas
1   Department of Cardiology, Laiko General Hospital, Athens, Greece
,
N. A. Viniou
2   Hematology Unit, 1st Dept. of Internal Medicine, University of Athens, Laiko General Hospital, Athens, Greece
,
P. Diamantopoulos
2   Hematology Unit, 1st Dept. of Internal Medicine, University of Athens, Laiko General Hospital, Athens, Greece
,
J. Barbetseas
1   Department of Cardiology, Laiko General Hospital, Athens, Greece
› Author Affiliations
Further Information

Publication History

received: 07 April 2015

accepted in revised form: 12 August 2015

Publication Date:
28 December 2017 (online)

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Summary

Heparin induced thrombocytopenia (HIT) is a prothrombotic syndrome initiated by platelet-activating auto-antibodies with potentially devastating complications. Once the diagnosis of HIT is suspected, discontinuation of heparin and treatment with an alternative anticoagulant are mandatory. While established drugs for HIT are no longer available, parenteral factor Xa inhibitors, thrombin inhibitors and perhaps the direct oral anticoagulants provide additional treatment options. The aim of this review was to highlight the current clinical aspects regarding HIT focusing on the role of novel medications.

Zusammenfassung

Die Heparin-induzierte Thrombopenie (HIT) ist eine prothrombotische Erkrankung, die durch thrombozytenaktivierende Autoantikörper hervorgerufen wird und fatale Komplikationen auslösen kann. Bei Verdacht auf eine HIT muss Heparin abgesetzt und ein anderes Antikoagulanz gegeben werden. Es gibt zwar keine ausdrücklichen Arzneimittel gegen HIT mehr, aber parenteral verabreichte Faktor-Xa-Inhibitoren, Thrombinhemmer und möglicherweise direkte orale Antikoagulanzien können weitere Therapieoptionen sein. Diese Übersicht soll die aktuellen klinischen Aspekte von HIT mit Schwerpunkt auf der Rolle der neuen Arzneimittel darlegen.

Keywords

HIT - DOAC

Schlüsselwörter

HIT - DOAC
 

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