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Journal of Pediatric Neurology 2009; 07(03): 311-314
DOI: 10.3233/JPN-2009-0299
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Fetal brain disruption sequence in surviving co-twins

Roxanne H. Melbourne Chambers
a   Department of Obstetrics Gynecology and Child Health, University of the West Indies, Kingston, Jamaica
,
Peter B. Johnson
b   Department of Surgery, Anesthesia, Intensive Care and Radiology, University of the West Indies, Kingston, Jamaica
,
Minerva M. Thame
a   Department of Obstetrics Gynecology and Child Health, University of the West Indies, Kingston, Jamaica
› Author Affiliations
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Publication History

04 August 2008

11 October 2008

Publication Date:
30 July 2015 (online)

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Abstract

Two male infants who were both survivors of monochorionic twin pregnancies in which there was intrauterine demise of one twin are described. These infants had features of microcephaly associated with radiologic features of porencephaly, hydranencephaly and microcranium. The diagnosis assigned was severe fetal brain disruption sequence. Both infants had severe developmental delay and one infant died suddenly at age 7 months. A comparison is made with previously reported cases. The diagnosis of fetal brain disruption sequence should be entertained in infants with severe congenital microcephaly with overlapping sutures associated with scalp rugae and should be anticipated in twin pregnancies in which there has been demise of one co-twin during the second trimester.

Keywords

Fetal brain disruption - twin pregnancy - microcephaly - microhydranencephaly