Thromb Haemost 2016; 116(03): 408-409
DOI: 10.1160/TH16-05-0361
T&H Insights
Schattauer GmbH

Altered fibrin clot structure in patients with atrial fibrillation and worsening renal function

Yee Cheng Lau*
1   University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Dudley Road, Birmingham, United Kingdom
,
Lewis J. Hardy*
2   Division of Cardiovascular and Diabetes Research, Theme Thrombosis, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom
,
Helen Philippou
2   Division of Cardiovascular and Diabetes Research, Theme Thrombosis, Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom
,
Andrew D. Blann
1   University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Dudley Road, Birmingham, United Kingdom
,
Gregory Y. H. Lip
1   University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Dudley Road, Birmingham, United Kingdom
› Author Affiliations
Further Information

Publication History

Received: 10 May 2016

Accepted: 15 May 2016

Publication Date:
28 November 2017 (online)

Note: The review process for this manuscript was fully handled by Christian Weber, Editor in Chief.

* Y. C. Lau and L. J. Hardy contributed equally to this project.


 
  • References

  • 1 Sjoland JA, Sidelmann JJ, Brabrand M. et al. Fibrin clot structure in patients with end-stage renal disease. Thromb Haemost 2007; 98: 339-345.
  • 2 Undas A, Kolarz M, Kopec G. et al. Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality. Nephrology Dial Transplant 2008; 23: 2010-2015.
  • 3 Undas A. Fibrin clot properties and their modulation in thrombotic disorders. Thromb Haemost 2014; 112: 32-42.
  • 4 Zabczyk M, Blombäck M, Majewski J. et al. Assays of fibrin network properties altered by VKAs in atrial fibrillation – importance of using an appropriate coagulation trigger. Thromb Haemost 2015; 113: 851-861.
  • 5 Mutch NJ, Engel R, Uitte de Willige S. et al. Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin. Blood 2010; 115: 3980-3988.