Thromb Haemost 2010; 103(02): 257-258
DOI: 10.1160/TH10-01-0004
Editorial Focus
Schattauer GmbH

Neointima formation after vascular injury: Is it all about CD39?

Pallavi Subramanian
1   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany
,
Andreas Schober
1   Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany
› Author Affiliations
Further Information

Publication History

Received: 04 January 2010

Accepted: 04 January 2010

Publication Date:
22 November 2017 (online)

 

 
  • References

  • 1 Ip JH, Fuster V, Israel D. et al. The role of platelets, thrombin and hyperplasia in restenosis after coronary angioplasty. J Am Coll Cardiol 1991; 17 6 Suppl B 77B-88B.
  • 2 Friedman RJ, Stemerman MB, Wenz B. et al. The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re- endothelialization. J Clin Invest 1977; 60: 1191-1201.
  • 3 Fingerle J, Johnson R, Clowes AW. et al. Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery. Proc Natl Acad Sci USA 1989; 86: 8412-8416.
  • 4 Steele PM, Chesebro JH, Stanson AW. et al. Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model. Circ Res 1985; 57: 105-112.
  • 5 Nobuyoshi M, Kimura T, Ohishi H. et al. Restenosis after percutaneous transluminal coronary angioplasty: pathologic observations in 20 patients. J Am Coll Cardiol 1991; 17: 433-439.
  • 6 Schober A, Zernecke A. Chemokines in vascular remodeling. Thromb Haemost 2007; 97: 730-737.
  • 7 Schober A, Zernecke A, Liehn EA. et al. Crucial role of the CCL2/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets. Circ Res 2004; 95: 1125-1133.
  • 8 Zernecke A, Schober A, Bot I. et al. SDF-1alpha/ CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res 2005; 96: 784-791.
  • 9 Tanguay JF, Geoffroy P, Sirois MG. et al. Prevention of in-stent restenosis via reduction of thrombo-inflammatory reactions with recombinant P-selectin glycoprotein ligand-1. Thromb Haemost 2004; 91: 1186-1193.
  • 10 Smyth SS, Reis ED, Zhang W. et al. Beta(3)-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adherent platelets 1 hour after injury. Circulation 2001; 103: 2501-2507.
  • 11 Schober A, Manka D, von Hundelshausen P. et al. Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation 2002; 106: 1523-1529.
  • 12 von Hundelshausen P, Petersen F, Brandt E. Platelet-derived chemokines in vascular biology. Thromb Haemost 2007; 97: 704-713.
  • 13 Acute platelet inhibition with abciximab does not reduce in-stent restenosis (ERASER study).. The ERASER Investigators. Circulation 1999; 100: 799-806.
  • 14 Schwartz L, Bourassa MG, Lesperance J. et al. Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty. N Engl J Med 1988; 318: 1714-1719.
  • 15 Savage MP, Goldberg S, Bove AA. et al. Effect of thromboxane A2 blockade on clinical outcome and restenosis after successful coronary angioplasty. Multi-Hospital Eastern Atlantic Restenosis Trial (M-HEART II). Circulation 1995; 92: 3194-3200.
  • 16 Munnix IC, Cosemans JM, Auger JM. et al. Platelet response heterogeneity in thrombus formation. Thromb Haemost 2009; 102: 1149-1156.
  • 17 Jennings LK. Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis. Thromb Haemost 2009; 102: 248-257.
  • 18 Drosopoulos JH, Kraemer R, Shen H. et al. Human solCD39 inhibits injury-induced development of neointimalhyperplasia. Thromb Haemost 2009; 103: 426-434.
  • 19 Marcus AJ, Broekman MJ, Drosopoulos JH. et al. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest 1997; 99: 1351-1360.
  • 20 Gayle RB, 3rd, Maliszewski CR, Gimpel SD. et al. Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39. J Clin Invest 1998; 101: 1851-1859.
  • 21 Takemoto Y, Kawata H, Soeda T. et al. Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis. Arterioscler Thromb Vasc Biol 2009; 29: 857-862.
  • 22 Koziak K, Bojakowska M, Robson SC. et al. Over-expression of CD39/nucleoside triphosphate diphosphohydrolase-1 decreases smooth muscle cell proliferation and prevents neointima formation after angioplasty. J Thromb Haemost 2008; 6: 1191-1197.
  • 23 Behdad A, Sun X, Khalpey Z. et al. Vascular smooth muscle cell expression of ectonucleotidase CD39 (ENTPD1) is required for neointimal formation in mice. Purinergic Signal 2009; 5: 335-342.
  • 24 Enjyoji K, Sevigny J, Lin Y. et al. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med 1999; 5: 1010-1017.
  • 25 Schober A. Chemokines in vascular dysfunction and remodeling. Arterioscler Thromb Vasc Biol 2008; 28: 1950-1959.
  • 26 Elliott MR, Chekeni FB, Trampont PC. et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 2009; 461: 282-286.
  • 27 Zernecke A, Bidzhekov K, Ozuyaman B. et al. CD73/ecto-5‘-nucleotidase protects against vascular inflammation and neointima formation. Circulation 2006; 113: 2120-2127.
  • 28 Yang D, Koupenova M, McCrann DJ. et al. The A2b adenosine receptor protects against vascular injury. Proc Natl Acad Sci USA 2008; 105: 792-796.