Download PDF
Thromb Haemost 2008; 100(06): 1203-1206
DOI: 10.1160/TH08-06-0350
Letters to the Editor
Schattauer GmbH

Excluding pulmonary embolism without imaging tests – Can our diagnostic algorithm be optimized?

Mathilde Nijkeuter
1   Department of General Internal Medicine-Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
,
Lidwine W. Tick
2   Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands
,
Maaike Sohne
3   Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
,
Marieke J. H. A. Kruip
4   Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands
,
Harry R. Buller
3   Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
,
Frank W. G. Leebeek
4   Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands
,
Mark H. H. Kramer
5   Department of Internal Medicine, Meander Medical Center, Amersfoort, the Netherlands
,
Frederikus A. Klok
1   Department of General Internal Medicine-Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
,
Martin H. Prins
6   Department of Clinical Epidemiology, Academic Medical Centre, Maastricht, the Netherlands
,
Menno V. Huisman
1   Department of General Internal Medicine-Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
,
the Christopher Study Investigators › Author AffiliationsFinancial support: This study was supported in part by unrestricted grants from the participating hospitals.
Further Information

Publication History

Received: 03 June 2008

Accepted after major revision: 17 September 2008

Publication Date:
23 November 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Wells PS, Anderson DR, Rodger M. et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med 2001; 135: 98-107.
    CrossrefPubMedGoogle Scholar
  • 2 Kruip MJ, Slob MJ, Schijen JH. et al. Use of a clinical decision rule in combination with D-dimer concentration in diagnostic workup of patients with suspected pulmonary embolism: a prospective management study. Arch Intern Med 2002; 162: 1631-1635.
    CrossrefPubMedGoogle Scholar
  • 3 Ten Wolde M, Hagen PJ, Macgillavry MR. et al. Non-invasive diagnostic work-up of patients with clinically suspected pulmonary embolism; results of a management study. J Thromb Haemost 2004; 02: 1110-1117.
    CrossrefPubMedGoogle Scholar
  • 4 Perrier A, Roy PM, Aujesky D. et al. Diagnosing pulmonary embolism in outpatients with clinical assessment, D-Dimer measurement, venous ultrasound, and helical computed tomography: a multicenter management study. Am J Med 2004; 116: 291-299.
    CrossrefPubMedGoogle Scholar
  • 5 van Belle A, Buller HR, Huisman MV. et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. J Am Med Assoc 2006; 295: 172-179.
    CrossrefPubMedGoogle Scholar
  • 6 van Beek EJ, Brouwerst EM, Song B. et al. Clinical validity of a normal pulmonary angiogram in patients with suspected pulmonary embolism--a critical review. Clin Radiol 2001; 56: 838-842.
    CrossrefPubMedGoogle Scholar
  • 7 Linkins LA, Bates SM, Ginsberg JS. et al. Use of different D-dimer levels to exclude venous thromboembolism depending on clinical pretest probability. J Thromb Haemost 2004; 02: 1256-1260.
    CrossrefPubMedGoogle Scholar
  • 8 Righini M, Aujesky D, Roy PM. et al. Clinical usefulness of D-dimer depending on clinical probability and cutoff value in outpatients with suspected pulmonary embolism. Arch Intern Med 2004; 164: 2483-2487.
    CrossrefPubMedGoogle Scholar