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Horm Metab Res 1980; 12(6): 236-239
DOI: 10.1055/s-2007-996256
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Tissue and Serum Somatostatin-Like Immunoreactivity in Lean and Obese Zucker Rats

M. C. Sheppard, B. Shapiro, A. Hudson, B. L. Pimstone
  • Isotope and Immunoassay Laboratory, Department of Medicine, University of Cape Town Medical School, Observatory, Republic of South Africa
Deceased 15th January 1979
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Publication History

1979

1979

Publication Date:
14 March 2008 (online)

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Summary

Tissue and serum somatostatin levels were measured in genetically lean and obese Zucker rats. Immunoreactive somatostatin content was decreased in three central nervous system regions (hypothalamus, septum and preoptic area and thalamus) of obese rats but was increased in cerebral cortex. No differences were observed in antral or colonic somatostatin content but obese animals had significantly elevated pancreatic levels. Portal vein somatostatin-like immunoreactivity in contrast was significantly lower in obese rats. The widespread alterations in tissue and serum somatostatin-like immunoreactivity suggest either a diffuse abnormality of somatostatin physiology or a response to a generalised feature of the obese hyperinsulinaemic state.

Key-Words

Somatostatin - Tissue and Serum - Zucker Rats

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