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Synfacts 2007(11): 1125-1125  
DOI: 10.1055/s-2007-991208
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Cruentaren A

Contributor(s): Philip Kocienski, Zofia Komsta
V. V. Vintonyak, M. E. Maier*
Universität Tübingen, Germany
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

Cruentaren A is a cytotoxic secondary metabolite of the myxobacterium Byssovorax cruenta. It efficiently inhibits mitochondrial F-ATPase from baker’s yeast. The salient feature of the synthesis is a ring-closing alkyne metathesis reaction to create macrolactone C.