Int J Sports Med 1994; 15(2): 100-104
DOI: 10.1055/s-2007-1021028
© Georg Thieme Verlag Stuttgart · New York

Evidence that the Effect of Bicycle Exercise on Blood Mononuclear Cell Proliferative Responses and Subsets is Mediated by Epinephrine

N. Tvede1 , M. Kappel2 , K. Klarlund3 , S. Duhn4 , J. Halkjœr-Kristensen1 , M. Kjœr1 , H. Galbo1 , B. K. Pedersen2
  • 1Laboratory of Medical Immunology and Laboratory of Exercise, Department of Medicine TTA, Rigshospitalet, University Hospital
  • 2Laboratory of Infectious Diseases, Rigshospitalet, University Hospital
  • 3Department of Cardiology, Bispebjerg Hospital
  • 4Department of Medicine, Roskilde County Hospital, Copenhagen, Denmark
Further Information

Publication History

Publication Date:
14 March 2008 (online)

Abstract

The present study was designed to test the hypothesis that the exercise-induced changes in blood mononuclear cell (BMNC) subsets, BMNC proliferative responses and lymphokine activated killer (LAK) cell activity are mediated by increased epinephrine concentrations. Healthy male volunteers 1) exercised on a bicycle ergometer (75% of V̇O2max, 1 h) and 2) on another day were given epinephrine as an intravenous infusion to obtain plasma epinephrine concentrations comparable with those seen during exercise. Blood samples were collected in the basal state, during the last minutes of exercise or epinephrine infusion and 2h later. During both perturbations the%CD3+ and%CD4+ T cells declined and the%CD16+ NK cells increased. Two h afterwards the CD14+ monocytes increased, while no changes were observed in%CD8+ T cells or%CD20+ T cells. The phytohemagglutinin (PHA) response declined during both epinephrine infusion and exercise experiments. The changes in interleukin-2 (IL-2) effect on proliferation and cytotoxic activity (LAK cell activity) were more pronounced in exercise experiments than during epinephrine. Exercise and epinephrine caused increase in concentrations of lymphocytes and neutrophils, but the changes were more pronounced in exercise experiments. The results indicate that, in response to physical exercise, the rise in plasma epinephrine may contribute to the changes in cellular immunity.