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Horm Metab Res 1981; 13(8): 430-433
DOI: 10.1055/s-2007-1019293
© Georg Thieme Verlag, Stuttgart · New York

Enhanced Insulin Secretion and Calcium Uptake by Zucker “Fatty” Rat Islets

A. R. Pansini1 , E. L. Tolman2
  • 1Department of Biochemistry, College of Medicine and Dentistry of New Jersey, New Jersey, U.S.A.
  • 2Metabolic Disease Research Section, Medical Research Division, American Cyanamid Company, New York, U.S.A.
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Publication History

1980

1980

Publication Date:
14 March 2008 (online)

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Summary

The relationship of the net uptake of calcium to insulin secretion by pancreatic islets isolated from Zucker “fatty” rats and their lean counterparts was studied. Islets from “fatty” rats secreted 1.5 to 3 times as much insulin as did the lean rat islets over a glucose concentration range of 0 to 27.7 mM. Over the same glucose concentration range, calcium accumulation was 2-fold greater in islets from the “fatty” rats than from the others. Both insulin secretion and calcium uptake were 2 to 3 fold greater for islets from the “fatty” rats than those from the lean animals over an extracellular calcium concentration range of up to 5 mEq/L. The data indicate that for islets isolated from Zucker “fatty” rats insulin hypersecretion in response to glucose and extracellular calcium is associated with enhanced calcium accumulation.

Key-Words:

Calcium - Insulin Secretion - Zucker “Fatty” Rats - Pancreatic Islets

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