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Horm Metab Res 1987; 19(7): 290-294
DOI: 10.1055/s-2007-1011803
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Increase in Insulin Secretion Induced by Plasma from Mice Injected with Allogeneic Lymphocytes

J. B. García1 , M. C. Venturino1 , J. C. Cresto1 , O. H. Pivetta2 , J. C. Basabe1
  • 1Fundación Laboratorios de Investigaciones Pediátricas (FLIP), Hospital General de Niños Dr. P. de Elizalde, Buenos Aires, Argentina
  • 2Instituto Nacional de Genética Médica, Buenos Aires, Argentina
Further Information

Publication History

1985

1986

Publication Date:
14 March 2008 (online)

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Summary

Plasma from BALB/c mice bled 90 minutes after allogeneic lymphocyte injection significantly rises glucose induced insulin secretion. This rise is observed in pancreas either from non-treated or from allogeneized mice. This rise is time and dose-dependent. An 1/40 dilution is enough to bring about a significant increase on insulin secretion. This effect is seen when mice are bled between 60 and 180 minutes after injection with a maximum effect at 90-120 minutes. Plasma from BALB/c mice injected with C57BL/6 J lymphocytes rises insulin secretion from BALB/c, C57BL/6 J, C3h and C57BL/KsJ mice pancreas. Plasma from streptozotocin diabetic BALB/c mice and from genetically diabetic C57BL/KsJ mdb-mdb mice injected with allogeneic lymphocytes stimulates glucose induced insulin secretion but to a lesser extent than plasma from normal non-diabetic mice does.

Key-Words

Insulin-Alloantigen-Diabetes

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