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Horm Metab Res 1991; 23(9): 407-409
DOI: 10.1055/s-2007-1003714
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© Georg Thieme Verlag, Stuttgart · New York

Effects of Glucagon-Like Peptide 1 (7-36) Amide and Glucagon on Amylin Release from Perfused Rat Pancreas

K. Inoue, A. Hisatomi, F. Umeda, H. Nawata
  • Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
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1990

1991

Publikationsdatum:
14. März 2008 (online)

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Summary

The effects of glucagon-like peptide 1 (7-36) amide [GLP-1(7-36)amide] and glucagon on the release of islet amyloid polypeptide (IAPP), or amylin, from the isolated perfused rat pancreas were studied. In the presence of 5.6 mM glucose, GLP-1 (7-36) amide and glucagon stimulated the release of amylin from the perfused pancreas. The infusion of GLP-1 (7-36) amide at a concentration of 10-9M elicited a biphasic release of amylin similar to that of insulin. The cumulative output of amylin induced by 10-9M GLP-1 (7-36) amide was significantly higher than that by 10-9M glucagon (p < 0.01). The amylin/insulin molar ratios induced by GLP-1 (7-36) amide and glucagon were about 1% and did not differ significantly. These findings suggest that GLP-1 (7-36) amide and glucagon stimulate the release of amylin from the pancreas and that the concomitant secretion of amylin and insulin might contribute to glucose homeostasis.

Key words

Amylin - Islet Amyloid Polypeptide - Glucagon-Like Peptide 1 - Glucagon - Pancreas Perfusion

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