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Horm Metab Res 1994; 26(4): 173-174
DOI: 10.1055/s-2007-1000805
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© Georg Thieme Verlag, Stuttgart · New York

Pancreastatin-Likelmmunoreactivity in the Pancreas of Newborn Rats

V. Štrbák1 , A. Dutour2 , M. Nikodémová1 , C. Oliver2
  • 1Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
  • 2Faculté de Médecine Nord, Laboratoire de Neuroendocrinologie Expérimentale, INSERM U. 297, Marseille, France
Further Information

Publication History

1992

1994

Publication Date:
14 March 2008 (online)

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Summary

Pancreastatin (PST), a novel COOH-terminally α-amidated peptide is a part of Chromogranin A molecule. Precursor processing implies also the final amidation step dependent on peptidylglycine α-amidating monooxygenase (PAM). High activity of PAM as well as Thyroliberin (TRH, another α-amidated peptide) concentration and biosynthesis were reported to be very high in neonatal rat pancreas. We followed the concentration of PST-like immunoreactivity in rat pancreas during ontogenesis. High perinatal PST concentration, resembling that of previously reported for PAM activity and TRH concentration was found. These findings suggest that perinatal PAM activation may affect a broader spectrum of pancreatic peptides.

Key words

Pancreastatin - Pancreas - Rat - Neonate - Amidated Peptides

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