Choleretic and Hepatoprotective Properties of Eupatorium cannabinum in the Rat

Annette Lexa; Jacques Fleurentin; Paul R. Lehr; François Mortier; Marc Pruvost; Jean-Marie Pelt

doi:10.1055/s-2006-961904

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Planta Med 1989; 55(2): 127-132
DOI: 10.1055/s-2006-961904

Papers

Choleretic and Hepatoprotective Properties of Eupatorium cannabinum in the Rat

Annette Lexa¹ , Jacques Fleurentin¹ , Paul R. Lehr² , François Mortier³ , Marc Pruvost⁴ , Jean-Marie Pelt¹ ^, ⁵

¹Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Université de Metz, 1, rue des Récollets, F-57000 Metz, France
²Laboratoire de Neurotoxicologie, Centre des Sciences de l'Environnement, Université de Metz, 1, rue des Récollets, F-57000 Metz, France
³Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Nancy, 5, rue Albert Lebrun, F-54000 Nancy, France
⁴Sanofi Recherche, 195, route d'Espagne, F-31035 Toulouse, France
⁵Institut Européen d'Ecologie, 1, rue des Récollets, F-57000 Metz, France

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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

According to our results, the traditional therapeutic indications of Eupatorium cannabinum L., choleretic and hepatoprotective effects, have been widely demonstrated. An aqueous extract induces hypercholeresis in the rat, the site of bile formation is canalicular in origin and both bile acid-dependant and bile acid-independant flows could be stimulated; the extract possesses anti-necrotic properties against carbon tetrachloride-induced hepatotoxicity, reducing widely the plasma GPT level in pretreated rats.

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