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Planta Med 1990; 56(4): 380-382
DOI: 10.1055/s-2006-960988
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© Georg Thieme Verlag Stuttgart · New York

Spectral Assignment and Cytotoxicity of 22-Hydroxytingenone from Glyptopetalum sclerocarpum

Rapepol Bavovada1 , Gábor Blaskó2 , 3 , Hui-Ling Shieh2 , John M. Pezzuto2 , Geoffrey A. Cordell2
  • 1Department of Pharmaceutical Botany, Chulalongkorn University, Bangkok, Thailand
  • 2Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  • 3EGIS Pharmaceuticals, Budapest, Hungary
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Publikationsverlauf

1989

Publikationsdatum:
05. Januar 2007 (online)

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Abstract

22-Hydroxytingenone was reisolated from a new source, Glyptopetalum sclerocarpum M. Laws and, for the first time, its unambiguous 13C-NMR assignments were accomplished through the use of APT, HETCOR, and selective INEPT spectroscopy. Intense, but nonspecific cytotoxic activity was observed when this substance was evaluated with a battery of cell lines comprised of the P-388 lymphocytic leukemia, KB carcinoma of the nasopharynx, and a number of human cancer cell types, i.e. HT-1080 fibrosarcoma, LU-1 lung cancer, COL-2 colon cancer, MEL-2 melanoma, and BC-1 breast cancer.

Key words

22-Hydroxytingenone - Glyptopetalum sclerocarpum - spectral assignment - cytotoxicity