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Planta Med 1990; 56(4): 360-363
DOI: 10.1055/s-2006-960982
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© Georg Thieme Verlag Stuttgart · New York

Effect of Salvianolic Acid A, a Depside from Roots of Salvia miltiorrhiza, on Gastric H+, K+-ATPase

Shigeru Murakami1 , Haruko Kijima1 , Yoshihiko Isobe1 , Makoto Muramatsu1 , Hironaka Aihara1 , Susumu Otomo1 , Li Liang-niang2 , Ai Chun-bo2
  • 1Research Center, Taisho Pharmaceutical Co. Ltd., Ohmiya, Saitama 330, Japan
  • 2Institute of Materia Medica, Chinese Academy of Medical Science, Beijing 100050, People's Republic of China
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Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Salvianolic acid A, a depside from the roots of Salvia miltiorrhiza, inhibited pig gastric H+,K+-ATPase and pNPPase with 50% inhibition values (IC50) of 5.2 × 10-7 M and 1.7 × 10-6 M, respectively. Kinetic studies revealed that the inhibition patterns induced by Salvianolic acid A were competitive with respect to ATP and noncompetitive with respect to K+. Salvianolic acid A (25 mg/kg, i.p.) significantly inhibited acid secretion in pylorus-ligated rats. At the same dose it also showed a significant reduction in the formation of gastric lesion induced by water immersion and restraint stress. These results suggest that Salvianolic acid A shows antisecretory and antiulcer activity by inhibiting the gastric H+,K+-ATPase.

Key words

H+, K+-ATPase - acid secretion - anti-ulcer - anti-secretory - salvianolic acid A - Salvia miltiorrhiza

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