Structures of Angular Pyranocoumarins of Bai-Hua Qian-Hu, the Root of Peucedanum praeruptorum1

M. Takata; S. Shibata; T. Okuyama

doi:10.1055/s-2006-960966

Planta Medica, Inhaltsverzeichnis

Planta Med 1990; 56(3): 307-311
DOI: 10.1055/s-2006-960966

Paper

Structures of Angular Pyranocoumarins of Bai-Hua Qian-Hu, the Root of Peucedanum praeruptorum ¹

M. Takata² , S. Shibata³ , T. Okuyama²

²Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Nozawa 1-35-23, Setagaya-ku, Tokyo 154, Japan
³Laboratory of Natural Medicinal Materials, c/o Minophagen Pharmaceutical Co., Yotsuya 3-2-7, Shinjuku-ku, Tokyo 160, Japan

1 Studies on Coumarins of a Chinese Drug „Qian-Hu”; Part X; for Part IX, see: Okuyama, T., Takata, M., Shibata, S. (1989) Planta Med. 55, 64

Abstract

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Abstract

Three new angular-type dihydropyranocoumarins, peucedanocoumarin I (1), peucedanocou-marin II (2), peucedanocoumarin III (3), and a known coumarin having the same skeleton, pteryxin (4), were isolated from the crude drug “Bai-Hua Qian-Hu“ of the Q-II type series, which is the root of Peucedanum praeruptorum Dunn. (Umbelliferae). The chemical structures of 1, 2, and 3 have been established by physicochemical methods to be 3′ (S)-2-methylbutyryloxy-4′-(R)-acetoxy-3′,4′-dihydroseselin, 3′(S)-acetoxy-4′(R)-angeloyloxy-3′,4′-dihydroseselin, and 3′(S)-acetoxy-4′(R)-tigloyloxy-3′,4′-dihydroseselin, respectively.

Key words

Bai-Hua Qian-Hu - Peucedanum praeruptorum - peucedanocoumarin I - peucedanocoumarin II - peucedanocoumarin III - pteryxin

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Structures of Angular Pyranocoumarins of Bai-Hua Qian-Hu, the Root of Peucedanum praeruptorum 1

Structures of Angular Pyranocoumarins of Bai-Hua Qian-Hu, the Root of Peucedanum praeruptorum ¹