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Planta Med 1991; 57(3): 250-253
DOI: 10.1055/s-2006-960084
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© Georg Thieme Verlag Stuttgart · New York

Structure and in vitro Antiviral Activity of Triterpenoid Saponins from Calendula arvensis*

Nunziatina De Tommasi1 , Cinzia Conti2 , Maria Luisa Stein3 , Cosimo Pizza1
  • 1Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli, Via D. Montesano 49, I-80131 Napoli, Italy
  • 2Istituto di Microbiologia, Facoltà di Medicina, Università degli Studi “La Sapienza”, P. le Aldo Moro 5, I-00185 Roma, Italy
  • 3Dipartimento di Studi farmaceutici, Università degli Studi “La Sapienza”, P. le Aldo Moro 5, I-00185 Roma, Italy
* This work is dedicated to Professor Giovanni Battista Marini-Bettolo on the occasion of his 75th birthday.
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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

A reinvestigation of the aerial parts of Calendula arvensis afforded, in addition to the oleanolic acid glycosides 1-4(4), the new glycoside 5 whose structure was elucidated by spectral and chemical studies and determined as 3-O-{β-D-galactopyranosyl-(1→3)[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranosyl}oleanolic acid (28→1)-β-D-glucopyranosyl ester. Furthermore, some antiviral tests were performed on glycosides 1-5 and on 5a, the hydrolysis product of 5, towards vesicular Stomatitis virus (VSV) and rhinovirus (HRV) infection in cell cultures. An inhibitory effect against VSV multiplication was observed for all the Compounds tested while HRV replication was significantly affected only by compound 3.

Key words

Calendula arvensis - oleanolic acid glycosides - vesicular stomatitis virus - rhinovirus - antiviral activity

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