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Planta Med 1993; 59(4): 318-322
DOI: 10.1055/s-2006-959690
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© Georg Thieme Verlag Stuttgart · New York

Effects of Oleuropeoside in Isolated Guinea-Pig Atria

Juan Duarte1 , Onésima Pérez2 , Antonio Zarzuelo1 , José Jiménez1 , Francisco Pérez-Vizcaíno2 , Juan Tamargo2
  • 1Department of Pharmacology, School of Pharmacy, University of Granada, E-18071 Granada, Spain
  • 2Department of Pharmacology, School of Medicine, University Complutense of Madrid, E-28040 Madrid, Spain
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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

The effects of oleuropeoside were studied on the electromechanical properties of isolated guinea-pig atria. In spontaneously beating right atria, oleuropeoside decreased the amplitude of contractions (IC50 = 1.3 ± 0.2 × 10-4M), slightly decreased atrial rate, and lengthened sinus node recovery time. Oleuropeoside also inhibited peak contractile force in electrically driven left atria incubated in normal (IC50 = 1.5 ± 0.5 × 10-4M) and in 27mM K+ Tyrode solution (IC50 = 1.7 ± 0.4 × 10-4M). These negative inotropic effects were not accompanied by significant changes in the characteristics of action potentials recorded in atria incubated in either normal or depolarizing solutions. These results indicate that oleuropeoside produced an electromechanical uncoupling that cannot be attributed to an inhibitory effect on Ca2+ entry through L-type channels. Therefore, the negative inotropic effect may reflect an action of oleuropeoside perhaps at an intracellular level.

Key words

Oleuropeoside - guinea-pig atria - contraction - action potential - Olea europaea

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