Acyl-CoA: Cholesterol Acyltransferase Inhibitors from Magnolia obovata

Byoung-Mog Kwon; Mi-Kyoung Kim; Seung-Ho Lee; Jeong-Ah Kim; Ihn-Rhan Lee; Young-Kook Kim; Song-Hae Bok

doi:10.1055/s-2006-957762

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Planta Med 1997; 63(6): 550-551
DOI: 10.1055/s-2006-957762

Letters

Acyl-CoA: Cholesterol Acyltransferase Inhibitors from Magnolia obovata

Byoung-Mog Kwon¹ , Mi-Kyoung Kim¹ , Seung-Ho Lee¹ , Jeong-Ah Kim² , Ihn-Rhan Lee² , Young-Kook Kim¹ , Song-Hae Bok¹

¹Protein Regulator RU, Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115 Yoosung, Taejon, Korea 305-600
²Ewha Womans University, College of Pharmacy, Seoul, Korea

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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

In the course of a search for acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors from natural sources, new types of ACAT inhibitors were isolated from the extract of Magnolia obovata leaves, and identified as obovatol, honokiol, and magnolol. The active compounds inhibit rat liver ACAT with IC₅₀ values of 42, 71, and 86 µM, respectively.

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