Studie eines ambulanten Patientenkollektivs mit Demenz aus den Landkreisen Passau und Rottal-Inn

Zusammenfassung

Anliegen Wir untersuchten Demenzpatienten mit Erkrankungsalter bis 70 Jahre deren Eltern aus den zwei Landkreisen stammen. Methode Anschreiben aller Hausärzte der Landkreise (Population 308 789). Ergebnisse 20 der 108 untersuchten Patienten erfüllten die Kriterien. 9 der 20 hatten mindestens einen Verwandten 1. Grades mit Demenz. Schlussfolgerungen Wir rechnen mit 160 Demenzpatienten, die aufgrund einer Abstammung aus der alteingesessenen Population interessant für genetische Studien sind.

Abstract

Objective To estimate the number of dementia patients with onset of cognitive decline before age 70 in the local population of two Bavarian counties (population 308 789 in 2004). This population is interesting for genetic analysis because of the unique resource of the region: a genealogical data bank with six million data sets for the periode 1580 - 1900. Methods We defined local probands as those dementia patients whose parents had also been born there. We contacted all 316 general practitioners (GPs) of the two counties. Results 7.6 % of the GPs took part in the survey. 85 of the 108 screened patients did not fulfill the study criteria. 3 patients dropped out of the study. Nine of the 20 remaining patients had at least one first-degree relative with a history of dementia. Conclusions We estimate that about 160 young dementia patients live in the two counties.

Schlüsselwörter

Alzheimer-Krankheit mit frühem Beginn - Plaque-only Alzheimer-Krankheit - Alois Alzheimer

Key words

early onset Alzheimer disease - plaque-only Alzheimer disease - Alois Alzheimer

Literatur

• 1 Klunemann H H, Fronhofer W, Wurster H. et al . Alzheimer's second patient: Johann F. and his family.  Ann Neurol. 2002;  52 520-523
• 2 Hofman A, Schulte S, Tanja T A. et al . History of dementia and Parkinson's disease in 1^st-degree relatives of patients with Alzheimer's disease.  Neurology. 1989;  39 1589-1592
• 3 Campion D. et al . Characteristics of familial aggregation in early-onset Alzheimer's disease: evidence of subgroups.  Am J Med Genet. 1995;  60 221-227
• 4 Fratigloni L. et al . Risk factors for late-onset Alzheimer's disease: a population-based, case-control study.  Ann Neurol. 1993;  33 258-266
• 5 Holmes C. et al . The clinical phenotype of familial and sporadic late onset Alzheimer's disease.  Int J Geriatr Psychiatry. 2002;  17 146-149
• 6 Kokmen E. The EURODEM collaborative re-analysis of case-control studies of Alzheimer's disease: implications for clinical research and practice.  Int J Epidemiol. 1991;  20, Suppl 2 S65-67
• 7 Lautenschlager N T. et al . Risk of dementia of Alzheimer's disease patients in the MIRAGE study: what is in store for the oldest old?.  Neurology. 1996;  46 641-650
• 8 Li G. et al . Age at onset and familial risk in Alzheimer's disease.  Am J Psychiatry. 1995;  152 424-430
• 9 Mayeux R, Sano M, Chen J. et al . Risk of dementia in 1^st-degree relatives of patients with Alzheimer's disease and related disorders.  Arch Neurol. 1991;  48 269-273
• 10 Schoenberg B S. et al . Alzheimer's disease and other dementing illnesses in a defined United States States Population: Incidence Rates and clinical features.  Ann Neurol. 1987;  22 724-729
• 11 Silverman J M, Li G, Zaccario M L. et al . Patterns of risk in first-degree relatives of patients with Alzheimer's disease.  Arch Gen Psychiatry. 1994;  51 577-586
• 12 Silverman J M. The consortium to establish a registry for Alzheimer's disease (CERAD). Part IV. Family history assessment: a multicenter study of first-degree relatives of Alzheimer's disease probands and nondemented spouse controls.  Neurology. 1994;  44 1253-1259
• 13 Silverman J M. et al . Has familial aggregation in Alzheimer's disease been overestimated.  Int J Geriatr Psychiatry. 2000;  15 631-637