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Horm Metab Res 2003; 35(6): 343-348
DOI: 10.1055/s-2003-41354
Original Basic
© Georg Thieme Verlag Stuttgart · New York

Bestatin Results in Pathophysiological Changes Similar to Preeclampsia in Rats Via Induction of Placental Apoptosis

Y.  Murata1 , Y.  Ohno1 , A.  Itakura1 , M.  Takeuchi1 , Y.  Nakashima1 , N.  Kuno1 , S.  Mizutani1
  • 1Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Japan
Further Information

Publication History

Received 13 August 2002

Accepted after Revision 29 January 2003

Publication Date:
15 August 2003 (online)

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Abstract

Objective: To establish a rat preeclampsia model with fetoplacental growth restriction caused by bestatin via induction of placental apoptosis. Study design: 200 mg/kg/day of bestatin or saline as a control were infused intraperitoneally into pregnant Wistar rats from 15 days' gestation. In the first experiment, maternal blood pressure and proteinuria were examined during the pre- and postpartum periods. In the second experiment, cesarean sections were performed at 20 days' gestation and the weights of pups and placentas, and levels of proteinuria and placental apoptosis were examined. Results: Physiological decrease of blood pressure in late pregnancy was not detected in the bestatin group but proteinuria level at 20 days' gestation was elevated. The weights of pups and placentas in the bestatin group were significantly lower than those in the controls, bestatin strongly inducing apoptosis in the placenta. Conclusion: Bestatin may cause a preeclampsia-like condition through induction of placental apoptosis.

Key words

Preeclampsia - Pregnancy - Trophoblast Apoptosis - Bestatin - Animal model

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Yasumasa Ohno, M. D.

Department of Obstetrics and Gynecology · Nagoya University Graduate School of Medicine

65 Tsurumai-cho · Showa-ku · Nagoya 466-8550 · Japan

Phone: + 81 (52) 744-2261 ·

Fax: + 81 (52) 744-2268

Email: yasumasa@med.nagoya-u.ac.jp

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