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Semin Reprod Med 2003; 21(2): 183-192
DOI: 10.1055/s-2003-41325
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Uterine and Ovarian Function in Endometriosis

Nicolás Garrido, Antonio Pellicer, José Remohí, Carlos Simón
  • Instituto Valenciano de Infertilidad (IVI) Fundación IVI (FIVI) Valencia, Spain
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Publikationsverlauf

Publikationsdatum:
14. August 2003 (online)

    Lizenzen und Reprints

ABSTRACT

Although numerous studies have attempted to elucidate the implication of endometriosis for infertility, this matter still remains unexplained. Diverse clinical approaches based on assisted reproduction techniques have produced conflicting results on this issue. Nevertheless, impairment of implantation and pregnancy rates seems to affect women who suffer from endometriosis. Whether this effect is due to alteration of the oocyte/embryo or the endometrium still remains to be elucidated, although actual data allude to deficiencies in both. Infertility due to poor quality embryos derived from impaired oocytes obtained from malfunctioning ovaries have been described by some groups. Endometrial defects have been argued by others. Adding more confusion to this topic, the influence of peritoneal fluid in women with endometriosis and/or mixed causes also needs to be considered. The aim of this review is to describe the current situation in the endometriosis-related infertility literature.

KEYWORDS

Endometriosis - uterus - endometrium - ovary - oocyte

REFERENCES

  • 1 Garrido N, Navarro J, García-Velasco J A. et al . The eutopic endometrium versus embryonic quality in endometriosis infertility.  Hum Reprod Update . 2002;  8 95-103
    CrossrefPubMedGoogle Scholar
  • 2 Garrido N, Navarro J, Remohí J. et al . Follicular hormonal environment and embryo quality in women with endometriosis.  Hum Reprod Update . 2000;  6 67-74
    CrossrefPubMedGoogle Scholar
  • 3 García-Velasco J, Arici A. Is the endometrium or the oocyte/ embryo affected in endometriosis?.  Hum Reprod . 1999;  14 (suppl 2) 77-89
    PubMedGoogle Scholar
  • 4 Simón C, Gutierrez A, Vidal A. et al . Outcome of patients with endometriosis in assisted reproduction: results from in vitro fertilization and oocyte donation.  Hum Reprod . 1994;  9 725-729
    PubMedGoogle Scholar
  • 5 Sung L, Mukherjee T, Takeshige T. et al . Endometriosis is not detrimental to embryo implantation in oocyte recipients.  J Assist Reprod Genet . 1997;  14 152-156
    CrossrefPubMedGoogle Scholar
  • 6 Pellicer A, Oliveira N, Ruiz A. et al . Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction.  Hum Reprod . 1995;  10 (suppl 2) 91-97
    CrossrefPubMedGoogle Scholar
  • 7 Brizek C L, Schlaff S, Pellegrini V A. et al . Increased incidence of aberrant morphological phenotypes in human embryogenesis-an association with endometriosis.  J Assist Reprod Genet . 1995;  12 106-112
    CrossrefPubMedGoogle Scholar
  • 8 Pellicer A, Oliveira N, Gutierrez A. et al .Implantation in endometriosis: lessons learned from IVF and oocyte donation. In: Spinola P y Coutinho EM Progress in Endometriosis. Casterton-Hill: Parthenon 1994: 177-183
    Google Scholar
  • 9 Díaz I, Navarro J, Blasco L. et al . Impact of stages III-IV of endometriosis on recipients of sibling oocytes. Matched case-control study.  Fertil Steril . 2000;  74 31-34
    CrossrefPubMedGoogle Scholar
  • 10 Harlow C R, Cahill D J, Maile L A. et al . Reduced preovulatory granulosa cell steroidogenesis in women with endometriosis.  J Clin Endocrinol Metab . 1996;  81 426-429
    CrossrefPubMedGoogle Scholar
  • 11 Pellicer A, Valbuena D, Bauset C. et al . The follicular endocrine environment in stimulated cycles of women with endometriosis: steroid levels and embryo quality.  Fertil Steril . 1998;  69 1135-1141
    CrossrefPubMedGoogle Scholar
  • 12 Beckmann M W, Polacek D, Seung L, Schreiber J R. Human ovarian granulosa cell culture: determination of blood cell contamination and evaluation of possible culture purification steps.  Fertil Steril . 1991;  56 881-887
    PubMedGoogle Scholar
  • 13 Garrido N, Krussel J S, Remohí J, et al., Expression and function of 3 beta hydroxysteroid dehydrogenase (3β HSD) type II and corticosteroid binding globulin (CBG) in granulosa cells from ovaries of women with and without endometriosis. J Assist Reprod Genet .  2002;  19 24-30
    PubMedGoogle Scholar
  • 14 Bukulmez O, Arici A. Leukocytes in ovarian function.  Hum Reprod Update . 2000;  6 1-15
    CrossrefPubMedGoogle Scholar
  • 15 Pellicer A, Albert C, Mercader A. et al . The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production.  Fertil Steril . 1998;  70 425-431
    CrossrefPubMedGoogle Scholar
  • 16 Garrido N, Albert C, Krüssel J S. et al . Expression, production, and secretion of vascular endothelial growth factor and interleukin-6 by granulosa cell are comparable in women with and without endometriosis.  Fertil Steril . 2001;  76 568-575
    CrossrefPubMedGoogle Scholar
  • 17 Garrido N, Albert C, Mercader A. et al .Leukocyte subpopulations in ovulatory follicles in patients with endometriosis (abstract 172). In: 15th Annual Meeting of the European Society of Human Reproduction and Embryology Tours (France). Hum Reprod 1999 14(abstract book 1): 227
    Google Scholar
  • 18 Lachapelle M H, Hemmings R, Roy D C. et al . Flow cytometric evaluation of leukocyte subpopulations in the follicular fluids of infertile patients.  Fertil Steril . 1996;  65 1135-1140
    PubMedGoogle Scholar
  • 19 Carlberg M, Nejaty J, Froysa B. et al . Elevated expression of tumor necrosis factor alpha in cultured granulosa cells from women with endometriosis.  Hum Reprod . 2000;  15 1250-1255
    CrossrefPubMedGoogle Scholar
  • 20 Nakahara K, Saito H, Saito T. et al . The incidence of apoptotic bodies in membrane granulosa can predict prognosis of ova from patients participating in vitro fertilization programs.  Fertil Steril . 1997;  68 312-317
    CrossrefPubMedGoogle Scholar
  • 21 Toya M, Saito H, Ohta N. et al . Moderate and severe endometriosis is associated with alterations in the cell cycle of granulosa cells in patients undergoing in vitro fertilization and embryo transfer.  Fertil Steril . 2000;  73 344-350
    CrossrefPubMedGoogle Scholar
  • 22 Nakahara K, Saito H, Saito T. et al . Ovarian fecundity in patients with endometriosis can be estimated by the incidence of apoptotic bodies.  Fertil Steril . 1998;  69 931-935
    CrossrefPubMedGoogle Scholar
  • 23 Lessey B A, Castelbaum A J, Buck C A. et al . Further characterization of endometrial integrins during the menstrual cycle and in pregnancy.  Fertil Steril . 1994;  62 497-506
    PubMedGoogle Scholar
  • 24 Lessey B A, Castelbaum A J, Sawin S W. et al . Aberrant integrin expression in the endometrium of women with endometriosis.  J Clin Endocrinol Metab . 1994;  79 643-649
    CrossrefPubMedGoogle Scholar
  • 25 Lessey B A, Young S Integrins and other cell adhesion molecules. Semin Reprod Endocrinol .  1997;  15 290-299
    PubMedGoogle Scholar
  • 26 Bridges J, Prentice A, Roche W. et al . Expression of integrin adhesion molecules in endometrium and endometriosis.  Br J Obstet Gynaecol . 1994;  101 696-700
    PubMedGoogle Scholar
  • 27 Hill L, Rogers P Endometrial vascular and glandular expression of integrins alpha (v) beta 3 in women with and without endometriosis. Hum Reprod .  1998;  13 1030-1035
    PubMedGoogle Scholar
  • 28 Creus M, Balasch J, Ordi J, et al Integrin expression in normal and out-of-phase endometria. Hum Reprod .  1998;  13 3460-3468
    PubMedGoogle Scholar
  • 29 Lessey B A. Implantation defects in infertile women with endometriosis.  Ann N Y Acad Sci . 2002;  955 265-280
    CrossrefPubMedGoogle Scholar
  • 30 Noble L, Simpson E, Johns A. et al . Aromatase expression in endometriosis.  J. Clin Endocrinol Metab . 1996;  81 174-179
    CrossrefPubMedGoogle Scholar
  • 31 Bulun S E, Gurates B, Fang Z. et al . Mechanisms of excessive estrogen formation in endometriosis.  J Reprod Immunol . 2002;  55 21-33
    CrossrefPubMedGoogle Scholar
  • 32 Zeitoun K, Takayama K, Sasano H. et al . Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol.  J Clin Endocrinol Metab . 1998;  83 4474-4480
    CrossrefPubMedGoogle Scholar
  • 33 Valbuena D, Jasper M, Remohí J. et al . Ovarian stimulation and endometrial receptivity.  Hum Reprod . 1999;  14 (suppl 2) 107-111
    CrossrefPubMedGoogle Scholar
  • 34 Taylor H, Arici A, Olive D. et al . HOXA 10 is expressed in response to sex steroids at the time of implantation in the human endometrium.  J Clin Invest . 1998;  101 1379-1384
    CrossrefPubMedGoogle Scholar
  • 35 Taylor H, Igarashi P, Olive D. et al . Sex steroids mediate HOXA 11 expression in the human peri-implantation endometrium.  J Clin Endocrinol Metab . 1999;  84 1129-1135
    CrossrefPubMedGoogle Scholar
  • 36 Taylor H S, Bagot C, Kardana A. et al . HOX gene expression is altered in the endometrium of women with endometriosis.  Hum Reprod . 1999;  14 1328-1331
    CrossrefPubMedGoogle Scholar
  • 37 Tanaka T, Umesaki N, Mizuno K. Anti-endometrial IgM autoantibodies in endometriotic patients: a preliminary study.  Clin Exp Obstet Gynecol . 2000;  27 133-137
    PubMedGoogle Scholar
  • 38 Tabibzadeh S, Mason J M, Shea W. et al . Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility.  J Clin Endocrinol Metab . 2000;  85 2526-2536
    CrossrefPubMedGoogle Scholar
  • 39 Ota H, Igarashi S, Kato N. et al . Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis.  Fertil Steril . 2000;  74 313-318
    CrossrefPubMedGoogle Scholar
  • 40 Galán A, O'Connor J E, Valbuena D. et al . The human blastocyst regulates endometrial epithelial apoptosis in embryonic adhesion.  Biol Reprod . 2000;  63 430-439
    PubMedGoogle Scholar
  • 41 Vaux D, Cory S, Adams J. Bcl-2 gene promotes haemopoietic cells survival and cooperates with c-myc to immortalize pre-B cells.  Nature . 1988;  335 440-442
    CrossrefPubMedGoogle Scholar
  • 42 Otsuki Y, Misaki O, Sugimoto O. et al . Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle.  Lancet . 1994;  344 28-29
    PubMedGoogle Scholar
  • 43 Tao X J, Tilly K I, Maravei D V. Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium: glandular epithelial cells apoptosis is associated with increased expression of bax.  J Clin Endocrinol Metab . 1997;  82 2739-2746
    PubMedGoogle Scholar
  • 44 McLaren J, Prentice A, Charnock-Jones D. et al . Immunolocalization of the apoptosis regulating proteins Bcl-2 and Bax in human endometrium and isolated peritoneal fluid macrophages in endometriosis.  Hum Reprod . 1997;  12 146-152
    CrossrefPubMedGoogle Scholar
  • 45 Jones R K, Searle R F, Bulmer J N. Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis.  Hum Reprod . 1998;  13 3496-3502
    CrossrefPubMedGoogle Scholar
  • 46 Watanabe H, Kanzaki H, Narukawa S. et al . Bcl-2 and Fas expression in eutopic and ectopic human endometrium during the menstrual cycle in relation to endometrial cell apoptosis.  Am J Obstet Gynecol . 1997;  176 360-368
    CrossrefPubMedGoogle Scholar
  • 47 García-Velasco J, Arici A, Zreik T. et al . Macrophage derived growth factors modulated Fas ligand expression in culture endometrial stromal cells: a role in endometriosis.  Mol Hum Reprod . 1999;  5 642-650
    CrossrefPubMedGoogle Scholar
  • 48 Gebel H M, Braun D P, Tambur A. et al . Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis.  Fertil Steril . 1998;  69 1042-1047
    CrossrefPubMedGoogle Scholar
  • 49 Dmowski W P, Gebel H, Braun D P. Decreased apoptosis and sensitivity to macrophage mediated cytolysis of endometrial cells in endometriosis.  Hum Reprod Update . 1998;  4 696-701
    CrossrefPubMedGoogle Scholar
  • 50 Dmowski W P, Ding J, Shen J. et al . Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis.  Hum Reprod . 2001;  16 1802-1808
    CrossrefPubMedGoogle Scholar
  • 51 Riesewijk A, Martín J, van Os R. Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology.  Mol Hum Reprod . 2003;  9 253-264
    CrossrefPubMedGoogle Scholar
  • 52 Kao L C, Tulac S, Lobo S. et al . Global gene profiling in human endometrium during the window of implantation.  Endocrinology . 2002;  143 2119-3853
    CrossrefPubMedGoogle Scholar
  • 53 Eyster K M, Boles A L, Brannian J D. et al . DNA microarray analysis of gene expression markers of endometriosis.  Fertil Steril . 2002;  77 38-42
    CrossrefPubMedGoogle Scholar
  • 54 Kao L C, Tulac S, Imani B. et al . Expression profile comparisons in eutopic endometrium between women with and without endometriosis during the window of implantation.  Fertil Steril . 2001;  77 (suppl 1) S27-S28
    PubMedGoogle Scholar
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