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Fortschr Neurol Psychiatr 2003; 71(1): 17-23
DOI: 10.1055/s-2003-36683
Originalarbeit
© Georg Thieme Verlag Stuttgart · New York

Trigeminoautonome Kopfschmerzsyndrome

Trigemino-Autonomic Headache SyndromesV.  Busch1 , A.  May1
  • 1Neurologische Universitätsklinik Regensburg
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Publication History

Publication Date:
16 January 2003 (online)

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Zusammenfassung

Der Artikel gibt eine Übersicht über die charakteristischen Merkmale einer Gruppe von seltenen aber schweren primären Kopfschmerzsyndromen ohne strukturelle Läsionen, die als sog. Trigeminoautonome Kopfschmerzen zusammengefasst werden. Die eigentlichen Schmerzen sind begleitet von autonomen Symptomen wie einer konjunktivalen Injektion, Lakrimation, Rhinorrhö, Ptosis oder einer Augenlidschwellung. Der Artikel fasst die diagnostischen Kriterien, die Epidemiologie und die Therapie dieser Kopfschmerzerkrankungen zusammen.

Abstract

This review describes the characteristics of some rare severe primary headache syndromes without any structural lesions, which are summarized as the trigemino-autonomic headaches. Pain in these syndromes is associated with autonomic symptoms such as conjunctival injection, lacrimation, rhinorrhoe, ptosis or eyelid edema. This article summarizes the diagnostics, epidemiology and therapy of these conditions.

Literatur

  • 1 Goadsby P J, Lipton R B. A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic feature, including new cases.  Brain. 1997;  120 (Pt 1) 193-209
    CrossrefPubMedGoogle Scholar
  • 2 May A. et al . Correlation between structural and functional changes in brain in an idiopathic headache syndrome.  Nat Med. 1999;  5 (7) 836-838
    CrossrefPubMedGoogle Scholar
  • 3 Goadsby P J. Trigeminal autonomic cephalgias (TACs).  Acta Neurol Belg. 2001;  101 (1) 10-19
    PubMedGoogle Scholar
  • 4 Goadsby P J. Short-lasting primary headaches: focus on trigeminal automatic cephalgias and indomethacin-sensitive headaches.  Curr Opin Neurol. 1999;  12 (3) 273-277
    CrossrefPubMedGoogle Scholar
  • 5 Hardebo J E. Subcutaneous sumatriptan in cluster headache: a time study of the effect on pain and autonomic symptoms.  Headache. 1993;  33 (1) 18-21
    CrossrefPubMedGoogle Scholar
  • 6 Chazot G. et al . A chronobiological study of melatonin, cortisol growth hormone and prolactin secretion in cluster headache.  Cephalalgia. 1984;  4 (4) 213-220
    CrossrefPubMedGoogle Scholar
  • 7 Leone M. et al . Neuroendocrine dysfunction in cluster headache.  Cephalalgia. 1990;  10 (5) 235-239
    CrossrefPubMedGoogle Scholar
  • 8 May A. et al . Hypothalamic activation in cluster headache attacks.  Lancet. 1998;  352 (9124) 275-278
    CrossrefPubMedGoogle Scholar
  • 9 May A. et al . PET and MRA findings in cluster headache and MRA in experimental pain.  Neurology. 2000;  55 (9) 1328-1335
    PubMedGoogle Scholar
  • 10 Sjaastad O. Cluster headache: the possible significance of midline structures.  Cephalalgia. 1988;  8 (4) 229-236
    CrossrefPubMedGoogle Scholar
  • 11 Headache Classification Committee of the International Headache Society . Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain.  Cephalalgia. 1988;  8 (7) 1-96
    CrossrefPubMedGoogle Scholar
  • 12 Sjaastad O, Shen J M. Cluster headache. Our current concepts.  Acta Neurol (Napoli). 1991;  13 (6) 500-505
    PubMedGoogle Scholar
  • 13 Sjaastad O. On the classification of cluster headache.  Cephalalgia. 1986;  6 (2) 65-68
    PubMedGoogle Scholar
  • 14 D'Alessandro R. et al . Cluster headache in the Republic of San Marino.  Cephalalgia. 1986;  6 (3) 159-162
    CrossrefPubMedGoogle Scholar
  • 15 Bahra A, May A, Goadsby P J. Cluster headache: a prospective clinical study with diagnostic implications.  Neurology. 2002;  58 (3) 354-361
    CrossrefPubMedGoogle Scholar
  • 16 Leone M. et al . Increased familial risk of cluster headache.  Neurology. 2001;  56 (9) 1233-1236
    PubMedGoogle Scholar
  • 17 Reik Jr L. Cluster headache after head injury.  Headache. 1987;  27 (9) 509-510
    CrossrefPubMedGoogle Scholar
  • 18 Turkewitz L J. et al . Cluster headache following head injury: a case report and review of the literature.  Headache. 1992;  32 (10) 504-506
    CrossrefPubMedGoogle Scholar
  • 19 Manzoni G C, Terzano M G, Lechi A. [Clinical and therapeutic aspects of chronic cluster headache].  Acta Biomed Ateneo Parmense. 1981;  52 (1) 11-19
    PubMedGoogle Scholar
  • 20 Henry P, Lucas J. Spontaneous evolution of cluster headache.  Cephalalgia. 1985;  5 (suppl. 3) 264-265
    PubMedGoogle Scholar
  • 21 Kudrow L. Natural history of cluster headache. Part I. Outcome of drop-out patients.  Headache. 1982;  22 (5) 203-206
    CrossrefPubMedGoogle Scholar
  • 22 Hardebo J E, Ekman R, Eriksson M. Low CSF met-enkephalin levels in cluster headache are elevated by acupuncture.  Headache. 1989;  29 (8) 494-497
    CrossrefPubMedGoogle Scholar
  • 23 Gobel H. et al . [Acute therapy of episodic and chronic cluster headache with sumatriptan s. c. Results of a one-year long-term study].  Nervenarzt. 1998;  69 (4) 320-329
    CrossrefPubMedGoogle Scholar
  • 24 Kudrow L. Response of cluster headache attacks to oxygen inhalation.  Headache. 1981;  21 (1) 1-4
    CrossrefPubMedGoogle Scholar
  • 25 Fogan L. Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation.  Arch Neurol. 1985;  42 (4) 362-363
    CrossrefPubMedGoogle Scholar
  • 26 Hardebo J E, Elner A. Nerves and vessels in the pterygopalatine fossa and symptoms of cluster headache.  Headache. 1987;  27(10) 528-532
    CrossrefPubMedGoogle Scholar
  • 27 Kittrelle J P, Grouse D S, Seybold M E. Cluster headache. Local anesthetic abortive agents.  Arch Neurol. 1985;  42 (5) 496-498
    PubMedGoogle Scholar
  • 28 group . T.s. c. h. s., treatment of acute cluster headache with sumatriptan.  N Engl J Med. 1991;  325 321-326
    PubMedGoogle Scholar
  • 29 Ekbom K. et al . Subcutaneous sumatriptan in the acute treatment of cluster headache: a dose comparison study.  The Sumatriptan Cluster Headache Study Group. Acta Neurol Scand. 1993;  88 (1) 63-69
    PubMedGoogle Scholar
  • 30 Dahlof C, Ekbom K, Persson L. Clinical experiences from Sweden on the use of subcutaneously administered sumatriptan in migraine and cluster headache.  Arch Neurol. 1994;  51 (12) 1256-1261
    PubMedGoogle Scholar
  • 31 Meyer F P. Clinical and hemodynamics effects during treatment of vascular headaches with verapamil.  headache. 1984;  24 313-321
    PubMedGoogle Scholar
  • 32 Gabai I J, Spierings E L. Prophylactic treatment of cluster headache with verapamil.  Headache. 1989;  29 (3) 167-168
    CrossrefPubMedGoogle Scholar
  • 33 Bussone G. et al . Double blind comparison of lithium and verapamil in cluster headache prophylaxis.  Headache. 1990;  30 (7) 411-417
    CrossrefPubMedGoogle Scholar
  • 34 Alberca R. et al . [Prophylactic treatment of episodic cluster headaches with methysergide and prednisone].  Arch Neurobiol (Madr). 1989;  52 (4) 183-187
    PubMedGoogle Scholar
  • 35 Graham J R. Cluster headache.  Postgrad Med. 1974;  56 (3) 181-185
    PubMedGoogle Scholar
  • 36 Kudrow D B. Cluster Headache: mechanisms and management. London: Oxford university press 1980
    Google Scholar
  • 37 Raskin N H. cluster headache, ed. headache. New York: Churchill Livingstone 1988: 229-254
    Google Scholar
  • 38 Mathew N T. Clinical subtypes of cluster headache and response to lithium therapy.  Headache. 1978;  18 (1) 27-29
    PubMedGoogle Scholar
  • 39 Manzoni G C. et al . Lithium carbonate in cluster headache: assessment of its short- and long-term therapeutic efficacy.  Cephalalgia. 1983;  3 (2) 109-114
    CrossrefPubMedGoogle Scholar
  • 40 Sjaastad O. et al . Chronic paroxysmal hemicrania (CPH). The clinical manifestations. A review.  Ups J Med Sci Suppl. 1980;  31 27-33
    PubMedGoogle Scholar
  • 41 Antonaci F, Sjaastad O. Chronic paroxysmal hemicrania (CPH): a review of the clinical manifestations.  Headache. 1989;  29 (10) 648-656
    CrossrefPubMedGoogle Scholar
  • 42 Sjaastad O. et al . CPH and hemicrania continua: requirements of high indomethacin dosages - an ominous sign?.  Headache. 1995;  35 (6) 363-367
    CrossrefPubMedGoogle Scholar
  • 43 Sjaastad O, Dale I. A new (?) Clinical headache entity “chronic paroxysmal hemicrania” 2.  Acta Neurol Scand. 1976;  54 (2) 140-159
    PubMedGoogle Scholar
  • 44 Manzoni G C. et al . Cluster headache - clinical findings in 180 patients.  Cephalalgia. 1983;  3 (1) 21-30
    CrossrefPubMedGoogle Scholar
  • 45 Sjaastad O. Chronic paroxysmal hemicrania: recent developments.  Cephalalgia. 1987;  7 (3) 179-188
    CrossrefPubMedGoogle Scholar
  • 46 Hannerz J, Ericson K, Bergstrand G. Chronic paroxysmal hemicrania: orbital phlebography and steroid treatment. A case report.  Cephalalgia. 1987;  7 (3) 189-192
    CrossrefPubMedGoogle Scholar
  • 47 Evers S, Husstedt I W. Alternatives in drug treatment of chronic paroxysmal hemicrania.  Headache. 1996;  36 (7) 429-432
    CrossrefPubMedGoogle Scholar
  • 48 Shabbir N, McAbee G. Adolescent chronic paroxysmal hemicrania responsive to verapamil monotherapy.  Headache. 1994;  34 (4) 209-210
    CrossrefPubMedGoogle Scholar
  • 49 Schlake H P. et al . Single photon emission computed tomography (SPECT) with 99mTc-HMPAO (hexamethyl propylenamino oxime) in chronic paroxysmal hemicrania - a case report.  Cephalalgia. 1990;  10 (6) 311-315
    CrossrefPubMedGoogle Scholar
  • 50 Bogucki A, Niewodniczy A. Case report: chronic cluster headache with unusual high frequency of attacks. Differential diagnosis with CPH.  Headache. 1984;  24 (3) 150-151
    PubMedGoogle Scholar
  • 51 Hannerz J, Jogestrand T. Intracranial hypertension and sumatriptan efficacy in a case of chronic paroxysmal hemicrania which became bilateral. (The mechanism of indomethacin in CPH).  Headache. 1993;  33 (6) 320-323
    CrossrefPubMedGoogle Scholar
  • 52 Warner J S, Wamil A W, McLean M J. Acetazolamide for the treatment of chronic paroxysmal hemicrania.  Headache. 1994;  34 (10) 597-599
    CrossrefPubMedGoogle Scholar
  • 53 Mathew N T, Kailasam J, Fischer A. Responsiveness to celecoxib in chronic paroxysmal hemicrania.  Neurology. 2000;  55 (2) 316
    PubMedGoogle Scholar
  • 54 Zukerman E. et al . “Hemicrania continua”: a case report.  Cephalalgia. 1987;  7 (3) 171-173
    CrossrefPubMedGoogle Scholar
  • 55 Iordanidis T, Sjaastad O. Hemicrania continua: a case report.  Cephalalgia. 1989;  9 (4) 301-303
    CrossrefPubMedGoogle Scholar
  • 56 Pareja J A. et al . “Hemicrania episodica” - a new type of headache or a pre-chronic stage of hemicrania continua?.  Headache. 1990;  30 (6) 344-346
    CrossrefPubMedGoogle Scholar
  • 57 Antonaci F. et al . Chronic paroxysmal hemicrania and hemicrania continua. Parenteral indomethacin: the ‘indotest’.  Headache. 1998;  38 (2) 122-128
    CrossrefPubMedGoogle Scholar
  • 58 Pareja J A. et al . Hemicrania continua: diagnostic criteria and nosologic status.  Cephalalgia. 2001;  21 (9) 874-877
    CrossrefPubMedGoogle Scholar
  • 59 Sjaastad O, Spierings E L. “Hemicrania continua”: another headache absolutely responsive to indomethacin.  Cephalalgia. 1984;  4 (1) 65-70
    CrossrefPubMedGoogle Scholar
  • 60 Newman L C, Lipton R B, Solomon S. Hemicrania continua: ten new cases and a review of the literature.  Neurology. 1994;  44 (11) 2111-2114
    PubMedGoogle Scholar
  • 61 Newman L C. et al . Episodic paroxysmal hemicrania: two new cases and a literature review.  Neurology. 1992;  42 (5) 964-966
    PubMedGoogle Scholar
  • 62 Pascual J. Hemicrania continua.  Neurology. 1995;  45 (12) 2302-2303
    PubMedGoogle Scholar
  • 63 Sjaastad O, Antonaci F. A piroxicam derivative partly effective in chronic paroxysmal hemicrania and hemicrania continua.  Headache. 1995;  35 (9) 549-550
    CrossrefPubMedGoogle Scholar
  • 64 Trucco M, Antonaci F, Sandrini G. Hemicrania continua: a case responsive to piroxicam-beta-cyclodextrin.  Headache. 1992;  32 (1) 39-40
    CrossrefPubMedGoogle Scholar
  • 65 Peres M F, Zukerman E. Hemicrania continua responsive to rofecoxib.  Cephalalgia. 2000;  20 (2) 130-131
    CrossrefPubMedGoogle Scholar
  • 66 Pareja J A. et al . SUNCT syndrome: duration, frequency, and temporal distribution of attacks.  Headache. 1996;  36 (3) 161-165
    CrossrefPubMedGoogle Scholar
  • 67 Sjaastad O. et al . Short-lasting unilateral neuralgiform headache attacks with conjunctival injection, tearing, etc. (SUNCT): III. Another Norwegian case.  Headache. 1991;  31 (3) 175-177
    CrossrefPubMedGoogle Scholar
  • 68 Pareja J A, Sjaastad O. SUNCT syndrome. A clinical review.  Headache. 1997;  37 (4) 195-202
    CrossrefPubMedGoogle Scholar
  • 69 Sjaastad O. et al . Shortlasting unilateral neuralgiform headache attacks with conjunctival injection, tearing, sweating, and rhinorrhea.  Cephalalgia. 1989;  9 (2) 147-156
    CrossrefPubMedGoogle Scholar
  • 70 Pareja J A, Sjaastad O. SUNCT syndrome in the female.  Headache. 1994;  34 (4) 217-220
    CrossrefPubMedGoogle Scholar
  • 71 Graff-Radford S B. SUNCT syndrome responsive to gabapentin (Neurontin).  Cephalalgia. 2000;  20 (5) 515-517
    CrossrefPubMedGoogle Scholar
  • 72 Pareja J A, Kruszewski P, Sjaastad O. SUNCT syndrome: trials of drugs and anesthetic blockades.  Headache. 1995;  35 (3) 138-142
    CrossrefPubMedGoogle Scholar
  • 73 Matharu M S, Boes C J, Goadsby P J. SUNCT syndrome: prolonged attacks, refractoriness and response to topiramate.  Neurology. 2002;  58 (8) 1307
    CrossrefPubMedGoogle Scholar
  • 74 Leone M. et al . Two new SUNCT cases responsive to lamotrigine.  Cephalalgia. 2000;  20 (9) 845-847
    CrossrefPubMedGoogle Scholar
  • 75 Ghose R R. SUNCT syndrome.  Med J Aust. 1995;  162 (12) 667-668
    PubMedGoogle Scholar
  • 76 Newman L C, Lipton R B, Solomon S. The hypnic headache syndrome: a benign headache disorder of the elderly.  Neurology. 1990;  40 (12) 1904-1905
    PubMedGoogle Scholar
  • 77 Raskin N H. The hypnic headache syndrome.  Headache. 1988;  28 (8) 534-536
    CrossrefPubMedGoogle Scholar
  • 78 Newman L C, Lipton R B, Solomon S. Hypnic headaches.  Headache. 1990;  30 (4) 227
    PubMedGoogle Scholar
  • 79 Dodick D W, Jones J M, Capobianco D J. Hypnic headache: another indomethacin-responsive headache syndrome?.  Headache. 2000;  40 (10) 830-835
    CrossrefPubMedGoogle Scholar
  • 80 Ivanez V, Soler R, Barreiro P. Hypnic headache syndrome: a case with good response to indomethacin.  Cephalalgia. 1998;  18 (4) 225-226
    CrossrefPubMedGoogle Scholar
  • 81 Vieira Dias M, Esperan P. a, [Hypnic headache: a report of four cases].  Rev Neurol. 2002;  34 (10) 950-951
    PubMedGoogle Scholar
  • 82 Raskin N H, Schwartz R K. Icepick-like pain.  Neurology. 1980;  30 (2) 203-205
    CrossrefPubMedGoogle Scholar
  • 83 Soriani S. et al . Juvenile idiopathic stabbing headache.  Headache. 1996;  36 (9) 565-567
    CrossrefPubMedGoogle Scholar
  • 84 Dangond F, Spierings E L. Idiopathic stabbing headaches lasting a few seconds.  Headache. 1993;  33 (5) 257-258
    CrossrefPubMedGoogle Scholar
  • 85 Sjaastad O. Cluster headache syndrome. London: WB Saunders 1992
    Google Scholar
  • 86 Ekbom K. Some observations on pain in cluster headache.  Headache. 1975;  14 (4) 219-225
    CrossrefPubMedGoogle Scholar
  • 87 Lansche R K. Ophthalmodynia periodica.  Headache. 1964;  4 247-249
    CrossrefPubMedGoogle Scholar
  • 88 Mathew N T. Indomethacin responsive headache syndromes.  Headache. 1981;  21 (4) 147-150
    CrossrefPubMedGoogle Scholar
  • 89 Medina J L, Diamond S. Cluster headache variant. Spectrum of a new headache syndrome.  Arch Neurol. 1981;  38 (11) 705-709
    PubMedGoogle Scholar
  • 90 Rasmussen B K. Epidemiology of headache.  Cephalalgia. 1995;  15 45-68
    PubMedGoogle Scholar
  • 91 Pareja J A. et al . Idiopathic stabbing headache (jabs and jolts syndrome).  Cephalalgia. 1996;  16 (2) 93-96
    CrossrefPubMedGoogle Scholar

V. Busch

Neurologische Klinik · Universitätsklinikum Regensburg

Universitätsstr. 84

93053 Regensburg

Email: busch.volker@gmx.de

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