Planta Med 2002; 68(4): 361-363
DOI: 10.1055/s-2002-26746
Letter
© Georg Thieme Verlag Stuttgart · New York

Antibacterial Diterpenoids from Fabiana densa var. ramulosa

Silvia Erazo1 , Mercedes Zaldívar2 , Carla Delporte1 , Nadine Backhouse1 , Paola Tapia2 , Eliana Belmonte3 , Franco Delle Monarche4 , Rosa Negrete1
  • 1Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile
  • 2Department of Biochemistry and Molecular Biology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile
  • 3Department of Archeology and Museumlogy, Faculty of Social, Administrative and Economical Science, University of Tarapaca, Arica, Chile
  • 4Centro Chimica dei Recettori, C.N.R., Roma, Italy
Further Information

Publication History

June 13, 2001

September 22, 2001

Publication Date:
02 May 2002 (online)

Abstract

A biologically monitored fractionation of the resinous exudate of Fabiana densa Remy var. ramulosa Wedd. led to the isolation of the two new diterpenes: ent-beyer-15-en-18-O-succinate and ent-beyer-15-en-18-O-oxalate as the unique compounds responsible for the observed antibacterial activity of this extract. Their structures were determined by 1D and 2D NMR spectroscopy.

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Silvia Erazo

Department of Pharmacological and Toxicological Chemistry

Faculty of Chemical and Pharmaceutical Sciences

University of Chile

P.O. Box 233, Santiago-1

Chile

Fax: +56-2-2227900

Email: serazo@uchile.cl