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Journal of Pediatric Neurology
DOI: 10.1055/s-0044-1786777
Special Issue Article

At the Origin of Brain Malformations: Embryology of the Central and Peripheral Nervous System

Paola Cavallaro   *
1   Pediatrics Postgraduate Residency Program, University of Messina, Messina, Italy
,
Michela Leotta   *
1   Pediatrics Postgraduate Residency Program, University of Messina, Messina, Italy
,
Daria La Cognata   *
2   Pediatrics Postgraduate Residency Program, University of Catania, Catania, Italy
,
Federica Dierna
2   Pediatrics Postgraduate Residency Program, University of Catania, Catania, Italy
,
Valeria Fichera
2   Pediatrics Postgraduate Residency Program, University of Catania, Catania, Italy
,
Michele Vecchio
3   Rehabilitation Unit, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
,
Agata Polizzi
4   Chair of Pediatrics, Department of Educational Sciences, University of Catania, Catania, Italy
,
Andrea D. Praticò
5   Chair of Pediatrics, Department of Medicine and Surgery, Kore University, Enna, Italy
,
Paola Castrogiovanni
6   Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
,
Giuseppe Musumeci
6   Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
,
Michelino Di Rosa
6   Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
,
Rossella Imbesi
6   Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
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Abstract

Development of the central nervous system is a time-ordered and multistepped process that begins in the third week of development and continues after birth. Understanding of its normal embryologic development is fundamental to understand how specific malformations develop. This article provides a summary of human brain development and serves as a base to introduce the various malformations presented in this issue.

Keywords

brain anatomy - embryology - neuronal migration - malformations - environmental factors

* These authors have equally contributed to this article.




Publikationsverlauf

Eingereicht: 11. Dezember 2023

Angenommen: 04. April 2024

Artikel online veröffentlicht:
13. Mai 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Müller F, O'Rahilly R. The development of the human brain, including the longitudinal zoning in the diencephalon at stage 15. Anat Embryol (Berl) 1988; 179 (01) 55-71
    CrossrefPubMedGoogle Scholar
  • 2 Incorpora G, Pavone P, Castellano-Chiodo D, Praticò AD, Ruggieri M, Pavone L. Gelastic seizures due to hypothalamic hamartoma: rapid resolution after endoscopic tumor disconnection. Neurocase 2013; 19 (05) 458-461
    CrossrefPubMedGoogle Scholar
  • 3 Haldipur P, Dang D, Millen KJ. Chapter 2 - Embryology. In: Manto M, Huisman TAGM. eds. Handbook of Clinical Neurology. Amsterdam:: Elsevier; 2018: 29-44
    Google Scholar
  • 4 Vitaliti G, Praticò AD, Cimino C. et al. Hepatitis B vaccine in celiac disease: yesterday, today and tomorrow. World J Gastroenterol 2013; 19 (06) 838-845
    CrossrefPubMedGoogle Scholar
  • 5 Sadler TW, Langman J. Langman's Medical Embryology. XIV ed. Philadelphia, USA:: Lippincott Williams; 2018
    Google Scholar
  • 6 Leonardi S, Praticò AD, Lionetti E, Spina M, Vitaliti G, La Rosa M. Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children. World J Gastroenterol 2012; 18 (40) 5729-5733
    CrossrefPubMedGoogle Scholar
  • 7 Bissonette GB, Roesch MR. Development and function of the midbrain dopamine system: what we know and what we need to. Genes Brain Behav 2016; 15 (01) 62-73
    CrossrefPubMedGoogle Scholar
  • 8 Palano GM, Praticò AD, Praticò ER. et al. Intossicazione accidentale da alcol etilico in un lattante di 30 giorni. Quadro clinico e follow-up neurologico. [Accidental ethyl alcohol intoxication in a 30-day-old infant. Clinical findings and neurological follow-up] Minerva Pediatr 2007; 59 (03) 275-279
    PubMedGoogle Scholar
  • 9 Nieuwenhuys R. The development and general morphology of the telencephalon of actinopterygian fishes: synopsis, documentation and commentary. Brain Struct Funct 2011; 215 (3-4): 141-157
    CrossrefPubMedGoogle Scholar
  • 10 Fiumara A, Lanzafame G, Arena A. et al. COVID-19 pandemic outbreak and its psychological impact on patients with rare lysosomal diseases. J Clin Med 2020; 9 (09) 2716
    CrossrefPubMedGoogle Scholar
  • 11 Folgueira M, Bayley P, Navratilova P, Becker TS, Wilson SW, Clarke JD. Morphogenesis underlying the development of the everted teleost telencephalon. Neural Dev 2012; 7: 32
    CrossrefPubMedGoogle Scholar
  • 12 Praticò AD, Leonardi S. Immunotherapy for food allergies: a myth or a reality?. Immunotherapy 2015; 7 (02) 147-161
    CrossrefPubMedGoogle Scholar
  • 13 Korzh V. Development of brain ventricular system. Cell Mol Life Sci 2018; 75 (03) 375-383
    CrossrefPubMedGoogle Scholar
  • 14 Praticò AD, Ruggieri M. COVID-19 vaccination for children: may be necessary for the full eradication of the disease. Pediatr Res 2021; 90 (06) 1102-1103
    CrossrefPubMedGoogle Scholar
  • 15 Patthey C, Gunhaga L, Edlund T. Early development of the central and peripheral nervous systems is coordinated by Wnt and BMP signals. PLoS One 2008; 3 (02) e1625
    CrossrefPubMedGoogle Scholar
  • 16 Praticò AD, Mistrello G, La Rosa M. et al. Immunotherapy: a new horizon for egg allergy?. Expert Rev Clin Immunol 2014; 10 (05) 677-686
    CrossrefPubMedGoogle Scholar
  • 17 Kiecker C, Niehrs C. A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus. Development 2001; 128 (21) 4189-4201
    CrossrefPubMedGoogle Scholar
  • 18 Praticò AD. COVID-19 pandemic for pediatric health care: disadvantages and opportunities. Pediatr Res 2021; 89 (04) 709-710
    CrossrefPubMedGoogle Scholar
  • 19 Nordström U, Jessell TM, Edlund T. Progressive induction of caudal neural character by graded Wnt signaling. Nat Neurosci 2002; 5 (06) 525-532
    CrossrefPubMedGoogle Scholar
  • 20 Praticò AD, Falsaperla R, Comella M, Belfiore G, Polizzi A, Ruggieri M. Case report: A gain-of-function of hamartin may lead to a distinct “inverse TSC1-hamartin” phenotype characterized by reduced cell growth. Front Pediatr 2023; 11: 1101026
    CrossrefPubMedGoogle Scholar
  • 21 Pavone P, Polizzi A, Longo MR. et al. Congenital myasthenic syndromes: clinical and molecular report on 7 Sicilian patients. J Pediatr Neurosci 2013; 8 (01) 19-21
    CrossrefPubMedGoogle Scholar