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Semin Respir Crit Care Med 2024; 45(01): 102-113
DOI: 10.1055/s-0043-1776913
Review Article

Chronic Pulmonary Aspergillosis as a Considerable Complication in Post-Tuberculosis Lung Disease

Matthias J. Neuböck
1   Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine 4 - Pneumology, Kepler University Hospital, Linz, Austria
2   Medical Faculty, Johannes Kepler University Linz, Linz, Austria
,
for CPAnet,
Gunar Günther
3   Department of Pulmonology and Allergology, Inselspital, Bern University Hospital, Bern, Switzerland
4   Department of Medical Sciences, Faculty of Health Sciences, University of Namibia, Windhoek, Namibia
,
Aleksandra Barac
5   Clinic for Infectious and Tropical Diseases, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
,
Jesper R. Davidsen
6   Department of Respiratory Medicine, Pulmonary Aspergillosis Centre Denmark, Odense University Hospital, Odense, Denmark
7   Department of Clinical Research, Odense Respiratory Research Unit, University of Southern Denmark, Odense, Denmark
,
Christian B. Laursen
6   Department of Respiratory Medicine, Pulmonary Aspergillosis Centre Denmark, Odense University Hospital, Odense, Denmark
7   Department of Clinical Research, Odense Respiratory Research Unit, University of Southern Denmark, Odense, Denmark
,
Ritesh Agarwal
8   Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Inderpaul S. Sehgal
8   Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Christoph Lange
9   Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
10   German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany
11   Respiratory Medicine and International Health, University of Lübeck, Lübeck, Germany
12   Baylor College of Medicine and Texas Children's Hospital, Global Tuberculosis Program, Houston, Texas
,
Helmut J.F. Salzer
1   Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine 4 - Pneumology, Kepler University Hospital, Linz, Austria
2   Medical Faculty, Johannes Kepler University Linz, Linz, Austria
13   Ignaz-Semmelweis-Institute, Interuniversity Institute for Infection Research, Vienna, Austria
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Abstract

Post-tuberculosis lung disease (PTLD) has only recently been put in the spotlight as a medical entity. Recent data suggest that up to 50% of tuberculosis (TB) patients are left with PTLD-related impairment after completion of TB treatment. The presence of residual cavities in the lung is the largest risk factor for the development of chronic pulmonary aspergillosis (CPA) globally. Diagnosis of CPA is based on four criteria including a typical radiological pattern, evidence of Aspergillus species, exclusion of alternative diagnosis, and a chronic course of disease. In this manuscript, we provide a narrative review on CPA as a serious complication for patients with PTLD.

Keywords

post-tuberculosis disease - post-tuberculosis lung disease - chronic pulmonary aspergillosis - fungal infection - Aspergillus


Publication History

Article published online:
09 January 2024

© 2024. Thieme. All rights reserved.

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