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Horm Metab Res 2016; 48(11): 771-778
DOI: 10.1055/s-0042-117719
Review
© Georg Thieme Verlag KG Stuttgart · New York

Type 2 Diabetes and Aging: A Not so Sweet Scenario for Bone

R. Dhaliwal
1   Endocrinology, Diabetes and Metabolism, Department of Medicine, State University of New York, Syracuse, NY, USA
,
C. J. Rosen
2   Center for Clinical & Translational Research, Maine Medical Center Research Institute, Scarborough, ME, USA
› Author Affiliations
Further Information

Publication History

received 21 December 2015

accepted 12 September 2016

Publication Date:
11 October 2016 (online)

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Abstract

Type 2 diabetes and fractures are associated with substantial mortality and morbidity in the aging population. Given the normal to high bone mineral density, skeletal fragility in type 2 diabetes is an intriguing topic of ongoing research. An improved understanding of the underlying mechanisms and regulators of bone pathology in diabetes is needed to formulate targeted prevention and intervention strategies in this high risk population. Although the changes in bone induced by aging and disease are divergent, the pathogenetic mechanisms of aging and type 2 diabetes, thus far known, are not mutually exclusive. These mechanisms may provide deeper insight into the quantitative and qualitative deficits to further our knowledge of diabetes-specific bone pathology.

Key words

diabetes mellitus - aging - bone quality - osteoporosis - senescence - advanced glycation end products
 

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