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Semin Neurol 2021; 41(01): 085-100
DOI: 10.1055/s-0040-1722723
Review Article

Neuropsychiatric Complications after Stroke

Katlyn Nemani
1   Departments of Neurology and Psychiatry, NYU Langone Health, New York, New York
,
Lindsey Gurin
2   Departments of Neurology, Psychiatry, and Rehabilitation Medicine, NYU Langone Health, New York, New York
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Abstract

Neuropsychiatric disturbances represent a common and uniquely challenging consequence of stroke. These disorders arise at the intersection of lesion-related brain dysfunction and psychological distress related to the event and its aftermath, making it difficult to identify what symptom is a direct physiological consequence of the stroke. Depression, anxiety, fatigue, apathy, emotionalism, and anger are the most common of these syndromes, and posttraumatic stress disorder related to the stroke event has become increasingly recognized as a relevant entity. Mania, obsessive–compulsive disorder, and psychosis are less commonly encountered but potentially highly debilitating conditions that may be underrecognized. Early identification and treatment may mitigate functional impairment and improve quality of life. Evidence-based guidelines from the general population are often relied upon to guide treatment. Further research is needed to understand and tailor treatment of these disorders in the poststroke population.

Keywords

stroke - neuropsychiatry - poststroke depression - anxiety - posttraumatic stress disorder - fatigue - apathy - emotionalism - anger - psychosis


Publication History

Article published online:
28 January 2021

© 2021. Thieme. All rights reserved.

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  • References

  • 1 Kraepelin E. Manic-Depressive Insanity and Paranoia. Translated by R. Mary Barclay from the Eighth German Edition of the ‘Textbook of Psychiatry’, vol. iii and iv. Edited by George M. Robinson. Edinburgh: E&S Livingstone; 1921 . Accessed June 20, 2019 at: https://archive.org/details/manicdepressivei00kraeuoft
    Google Scholar
  • 2 Bleuler E. Textbook of Psychiatry (Transl. of the 4th German Edition by Brill AA). New York: The Macmillan Company; 1924 . Accessed June 20, 2019 at: http://www.archive.org/details/textbookofpsychiOObleu
    Google Scholar
  • 3 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association. 2013. . Accessed February 15, 2019 at: https://doi.org/10.1176/appi.books.9780890425596
    CrossrefGoogle Scholar
  • 4 Towfighi A, Ovbiagele B, El Husseini N. et al; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Poststroke depression: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2017; 48 (02) e30-e43
    CrossrefPubMedGoogle Scholar
  • 5 Lanctôt KL, Lindsay MP, Smith EE. et al. Canadian Stroke Best Practice recommendations: mood, cognition and fatigue following stroke, 6th edition update 2019. Int J Stroke 2019; DOI: 10.1177/1747493019847334. . [Epub ahead of print]
    CrossrefPubMedGoogle Scholar
  • 6 Meader N, Moe-Byrne T, Llewellyn A, Mitchell AJ. Screening for poststroke major depression: a meta-analysis of diagnostic validity studies. J Neurol Neurosurg Psychiatry 2014; 85 (02) 198-206
    CrossrefPubMedGoogle Scholar
  • 7 Hackett ML, Yapa C, Parag V, Anderson CS. Frequency of depression after stroke: a systematic review of observational studies. Stroke 2005; 36 (06) 1330-1340
    CrossrefPubMedGoogle Scholar
  • 8 Ayerbe L, Ayis S, Wolfe CDA, Rudd AG. Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis. Br J Psychiatry 2013; 202 (01) 14-21
    CrossrefPubMedGoogle Scholar
  • 9 Hackett ML, Pickles K. Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies. Int J Stroke 2014; 9 (08) 1017-1025
    CrossrefPubMedGoogle Scholar
  • 10 Mitchell AJ, Sheth B, Gill J. et al. Prevalence and predictors of post-stroke mood disorders: a meta-analysis and meta-regression of depression, anxiety and adjustment disorder. Gen Hosp Psychiatry 2017; 47 (March): 48-60
    CrossrefPubMedGoogle Scholar
  • 11 Ayerbe L, Ayis S, Crichton S, Wolfe CDA, Rudd AG. The natural history of depression up to 15 years after stroke: the South London Stroke Register. Stroke 2013; 44 (04) 1105-1110
    CrossrefPubMedGoogle Scholar
  • 12 Ayis SA, Ayerbe L, Crichton SL, Rudd AG, Wolfe CDA. The natural history of depression and trajectories of symptoms long term after stroke: the prospective south London stroke register. J Affect Disord 2016; 194 (194) 65-71
    CrossrefPubMedGoogle Scholar
  • 13 House A, Dennis M, Mogridge L, Warlow C, Hawton K, Jones L. Mood disorders in the year after first stroke. Br J Psychiatry 1991; 158: 83-92
    CrossrefPubMedGoogle Scholar
  • 14 Kase CS, Wolf PA, Kelly-Hayes M, Kannel WB, Beiser A, D'Agostino RB. Intellectual decline after stroke: the Framingham Study. Stroke 1998; 29 (04) 805-812
    CrossrefPubMedGoogle Scholar
  • 15 Sackley CM, Mant J, McManus RJ. et al. Functional and emotional outcomes after transient ischemic attack: a 12-month prospective controlled cohort study. Int J Stroke 2019; 14 (05) 522-529
    CrossrefPubMedGoogle Scholar
  • 16 Wium-Andersen MK, Wium-Andersen IK, Prescott EIB, Overvad K, Jørgensen MB, Osler M. An attempt to explain the bidirectional association between ischaemic heart disease, stroke and depression: a cohort and meta-analytic approach. Br J Psychiatry 2019; DOI: 10.1192/bjp.2019.130. [Epub ahead of print]
    CrossrefPubMedGoogle Scholar
  • 17 Jørgensen TSH, Wium-Andersen IK, Wium-Andersen MK. et al. Incidence of depression after stroke, and associated risk factors and mortality outcomes, in a large cohort of Danish patients. JAMA Psychiatry 2016; 73 (10) 1032-1040
    CrossrefPubMedGoogle Scholar
  • 18 Blöchl M, Meissner S, Nestler S. Does depression after stroke negatively influence physical disability? A systematic review and meta-analysis of longitudinal studies. J Affect Disord 2019; 247: 45-56
    CrossrefPubMedGoogle Scholar
  • 19 Barker-Collo S, Feigin VL, Parag V, Lawes CM, Senior H. Auckland Stroke Outcomes Study. Part 2: Cognition and functional outcomes 5 years poststroke. Neurology 2010; 75 (18) 1608-1616
    CrossrefPubMedGoogle Scholar
  • 20 Pohjasvaara T, Vataja R, Leppävuori A, Kaste M, Erkinjuntti T. Depression is an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol 2001; 8 (04) 315-319
    CrossrefPubMedGoogle Scholar
  • 21 Feigin VL, Barker-Collo S, Parag V. et al; ASTRO study group. Auckland Stroke Outcomes Study. Part 1: Gender, stroke types, ethnicity, and functional outcomes 5 years poststroke. Neurology 2010; 75 (18) 1597-1607
    CrossrefPubMedGoogle Scholar
  • 22 Sen A, Bisquera A, Wang Y. et al. Factors, trends, and long-term outcomes for stroke patients returning to work: the South London Stroke Register. Int J Stroke 2019; 14 (07) 696-705
    CrossrefPubMedGoogle Scholar
  • 23 MacIntosh BJ, Edwards JD, Kang M. et al. Post-stroke fatigue and depressive symptoms are differentially related to mobility and cognitive performance. Front Aging Neurosci 2017; 9: 343
    CrossrefPubMedGoogle Scholar
  • 24 Feigin VL, Barker-Collo S, Parag V. et al; Auckland Regional Community Stroke Study Group. Prevalence and predictors of 6-month fatigue in patients with ischemic stroke: a population-based stroke incidence study in Auckland, New Zealand, 2002-2003. Stroke 2012; 43 (10) 2604-2609
    CrossrefPubMedGoogle Scholar
  • 25 Shi YZ, Xiang YT, Yang Y. et al. Depression after minor stroke: the association with disability and quality of life--a 1-year follow-up study. Int J Geriatr Psychiatry 2016; 31 (04) 421-427
    CrossrefPubMedGoogle Scholar
  • 26 Ebrahim S, Barer D, Nouri F. Affective illness after stroke. Br J Psychiatry 1987; 151 (01) 52-56
    CrossrefPubMedGoogle Scholar
  • 27 Ashaie SA, Hurwitz R, Cherney LR. Depression and subthreshold depression in stroke-related aphasia. Arch Phys Med Rehabil 2019; 100 (07) 1294-1299
    CrossrefPubMedGoogle Scholar
  • 28 Yu S, Arima H, Bertmar C. et al. Depression but not anxiety predicts recurrent cerebrovascular events. Acta Neurol Scand 2016; 134 (01) 29-34
    CrossrefPubMedGoogle Scholar
  • 29 Sibolt G, Curtze S, Melkas S. et al. Post-stroke depression and depression-executive dysfunction syndrome are associated with recurrence of ischaemic stroke. Cerebrovasc Dis 2013; 36 (5-6): 336-343
    CrossrefPubMedGoogle Scholar
  • 30 Cai W, Mueller C, Li YJ, Shen WD, Stewart R. Post stroke depression and risk of stroke recurrence and mortality: a systematic review and meta-analysis. Ageing Res Rev 2019; 50 (January): 102-109
    CrossrefPubMedGoogle Scholar
  • 31 Ayerbe L, Ayis S, Crichton SL, Rudd AG, Wolfe CDA. Explanatory factors for the increased mortality of stroke patients with depression. Neurology 2014; 83 (22) 2007-2012
    CrossrefPubMedGoogle Scholar
  • 32 Razmara A, Valle N, Markovic D. et al. Depression is associated with a higher risk of death among stroke survivors. J Stroke Cerebrovasc Dis 2017; 26 (12) 2870-2879
    CrossrefPubMedGoogle Scholar
  • 33 Bartoli F, Lillia N, Lax A. et al. Depression after stroke and risk of mortality: a systematic review and meta-analysis. Stroke Res Treat 2013; 2013: 862978
    PubMedGoogle Scholar
  • 34 Bartoli F, Di Brita C, Crocamo C, Clerici M, Carrà G. Early post-stroke depression and mortality: meta-analysis and meta-regression. Front Psychiatry 2018; 9: 530
    CrossrefPubMedGoogle Scholar
  • 35 Pan A, Sun Q, Okereke OI, Rexrode KM, Hu FB. Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review. JAMA 2011; 306 (11) 1241-1249
    CrossrefPubMedGoogle Scholar
  • 36 Wei J, Hou R, Zhang X. et al. The association of late-life depression with all-cause and cardiovascular mortality among community-dwelling older adults: systematic review and meta-analysis. Br J Psychiatry 2019; 215 (02) 449-455
    CrossrefPubMedGoogle Scholar
  • 37 Chemerinski E, Robinson RG, Kosier JT. Improved recovery in activities of daily living associated with remission of poststroke depression. Stroke 2001; 32 (01) 113-117
    CrossrefPubMedGoogle Scholar
  • 38 Li W, Ling S, Yang Y, Hu Z, Davies H, Fang M. Systematic hypothesis for post-stroke depression caused inflammation and neurotransmission and resultant on possible treatments. Neuroendocrinol Lett 2014; 35 (02) 104-109
    PubMedGoogle Scholar
  • 39 Subramanian SK, Chilingaryan G, Sveistrup H, Levin MF. Depressive symptoms influence use of feedback for motor learning and recovery in chronic stroke. Restor Neurol Neurosci 2015; 33 (05) 727-740
    PubMedGoogle Scholar
  • 40 Player MJ, Taylor JL, Weickert CS. et al. Neuroplasticity in depressed individuals compared with healthy controls. Neuropsychopharmacology 2013; 38 (11) 2101-2108
    CrossrefPubMedGoogle Scholar
  • 41 Pittenger C, Duman RS. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 2008; 33 (01) 88-109
    CrossrefPubMedGoogle Scholar
  • 42 Trajkova S, d'Errico A, Soffietti R, Sacerdote C, Ricceri F. Use of antidepressants and risk of incident stroke: a systematic review and meta-analysis. Neuroepidemiology 2019; 53 (3-4): 142-151
    CrossrefPubMedGoogle Scholar
  • 43 Trifirò G, Dieleman J, Sen EF, Gambassi G, Sturkenboom MC. Risk of ischemic stroke associated with antidepressant drug use in elderly persons. J Clin Psychopharmacol 2010; 30 (03) 252-258
    CrossrefPubMedGoogle Scholar
  • 44 Khanassov V, Hu J, Reeves D, van Marwijk H. Selective serotonin reuptake inhibitor and selective serotonin and norepinephrine reuptake inhibitor use and risk of fractures in adults: a systematic review and meta-analysis. Int J Geriatr Psychiatry 2018; 33 (12) 1688-1708
    CrossrefPubMedGoogle Scholar
  • 45 Eriksson M, Glader E-L, Norrving B, Asplund K. Poststroke suicide attempts and completed suicides: a socioeconomic and nationwide perspective. Neurology 2015; 84 (17) 1732-1738
    CrossrefPubMedGoogle Scholar
  • 46 Pompili M, Venturini P, Lamis DA. et al. Suicide in stroke survivors: epidemiology and prevention. Drugs Aging 2015; 32 (01) 21-29
    CrossrefPubMedGoogle Scholar
  • 47 Kutlubaev MA, Hackett ML. Part II: predictors of depression after stroke and impact of depression on stroke outcome: an updated systematic review of observational studies. Int J Stroke 2014; 9 (08) 1026-1036
    CrossrefPubMedGoogle Scholar
  • 48 Ayis SA, Rudd AG, Ayerbe L, Wolfe CDA. Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke: the South London Stroke Register. Eur J Neurol 2019; 26 (06) 872-879
    CrossrefPubMedGoogle Scholar
  • 49 Kapoor A, Scott C, Lanctot KL. et al. Symptoms of depression and cognitive impairment in young adults after stroke/transient ischemic attack. Psychiatry Res 2019; 279: 361-363
    CrossrefPubMedGoogle Scholar
  • 50 McCarthy MJ, Sucharew HJ, Alwell K. et al. Age, subjective stress, and depression after ischemic stroke. J Behav Med 2016; 39 (01) 55-64
    CrossrefPubMedGoogle Scholar
  • 51 Backhouse EV, McHutchison CA, Cvoro V, Shenkin SD, Wardlaw JM. Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: a systematic review and meta-analysis. PLoS One 2018; 13 (07) e0200525
    CrossrefPubMedGoogle Scholar
  • 52 Hackett ML, Anderson CS. Predictors of depression after stroke: a systematic review of observational studies. Stroke 2005; 36 (10) 2296-2301
    CrossrefPubMedGoogle Scholar
  • 53 Rohde D, Gaynor E, Large M. et al. The impact of cognitive impairment on poststroke outcomes: a 5-year follow-up. J Geriatr Psychiatry Neurol 2019; 32 (05) 275-281
    CrossrefPubMedGoogle Scholar
  • 54 Morsund ÅH, Ellekjær H, Gramstad A. et al. Cognitive and emotional impairment after minor stroke and non-ST-elevation myocardial infarction (NSTEMI): a prevalence study. Stroke Res Treat 2019; 2019: 2527384
    PubMedGoogle Scholar
  • 55 Douven E, Aalten P, Staals J. et al. Co-occurrence of depressive symptoms and executive dysfunction after stroke: associations with brain pathology and prognosis. J Neurol Neurosurg Psychiatry 2018; 89 (08) 859-865
    CrossrefPubMedGoogle Scholar
  • 56 Robinson RG, Kubos KL, Starr LB, Rao K, Price TR. Mood disorders in stroke patients. Importance of location of lesion. Brain 1984; 107 (Pt 1): 81-93
    CrossrefPubMedGoogle Scholar
  • 57 Robinson RG, Szetela B. Mood change following left hemispheric brain injury. Ann Neurol 1981; 9 (05) 447-453
    CrossrefPubMedGoogle Scholar
  • 58 Zhang Y, Zhao H, Fang Y, Wang S, Zhou H. The association between lesion location, sex and poststroke depression: meta-analysis. Brain Behav 2017; 7 (10) e00788
    CrossrefPubMedGoogle Scholar
  • 59 Narushima K, Kosier JT, Robinson RG. A reappraisal of poststroke depression, intra- and inter-hemispheric lesion location using meta-analysis. J Neuropsychiatry Clin Neurosci 2003; 15 (04) 422-430
    CrossrefPubMedGoogle Scholar
  • 60 Wei N, Yong W, Li X. et al. Post-stroke depression and lesion location: a systematic review. J Neurol 2015; 262 (01) 81-90
    CrossrefPubMedGoogle Scholar
  • 61 Carson AJ, MacHale S, Allen K. et al. Depression after stroke and lesion location: a systematic review. Lancet 2000; 356 (9224): 122-126
    CrossrefPubMedGoogle Scholar
  • 62 Wang Z, Zhu M, Su Z. et al. Post-stroke depression: different characteristics based on follow-up stage and gender-a cohort perspective study from Mainland China. Neurol Res 2017; 39 (11) 996-1005
    CrossrefPubMedGoogle Scholar
  • 63 Shi Y-Z, Xiang Y-T, Wu S-L. et al. The relationship between frontal lobe lesions, course of post-stroke depression, and 1-year prognosis in patients with first-ever ischemic stroke. PLoS One 2014; 9 (07) e100456
    CrossrefPubMedGoogle Scholar
  • 64 Huang J, Zhou F-C, Guan B. et al. Predictors of remission of early-onset poststroke depression and the interaction between depression and cognition during follow-up. Front Psychiatry 2019; 9: 738
    CrossrefPubMedGoogle Scholar
  • 65 Northcott S, Moss B, Harrison K, Hilari K. A systematic review of the impact of stroke on social support and social networks: associated factors and patterns of change. Clin Rehabil 2016; 30 (08) 811-831
    CrossrefPubMedGoogle Scholar
  • 66 Dhand A, Longstreth Jr WT, Chaves PHM, Dhamoon MS. Social network trajectories in myocardial infarction versus ischemic stroke. J Am Heart Assoc 2018; 7 (08) e008029
    CrossrefPubMedGoogle Scholar
  • 67 O'Keefe LM, Doran SJ, Mwilambwe-Tshilobo L, Conti LH, Venna VR, McCullough LD. Social isolation after stroke leads to depressive-like behavior and decreased BDNF levels in mice. Behav Brain Res 2014; 260: 162-170
    CrossrefPubMedGoogle Scholar
  • 68 De Ryck A, Fransen E, Brouns R. et al. Poststroke depression and its multifactorial nature: results from a prospective longitudinal study. J Neurol Sci 2014; 347 (1-2): 159-166
    CrossrefPubMedGoogle Scholar
  • 69 Ouimet MA, Primeau F, Cole MG. Psychosocial risk factors in poststroke depression: a systematic review. Can J Psychiatry 2001; 46 (09) 819-828
    CrossrefPubMedGoogle Scholar
  • 70 Morris PL, Robinson RG, Raphael B, Bishop D. The relationship between the perception of social support and post-stroke depression in hospitalized patients. Psychiatry 1991; 54 (03) 306-316
    CrossrefPubMedGoogle Scholar
  • 71 Storor DL, Byrne GJA. Pre-morbid personality and depression following stroke. Int Psychogeriatr 2006; 18 (03) 457-469
    CrossrefPubMedGoogle Scholar
  • 72 Aben I, Denollet J, Lousberg R, Verhey F, Wojciechowski F, Honig A. Personality and vulnerability to depression in stroke patients: a 1-year prospective follow-up study. Stroke 2002; 33 (10) 2391-2395
    CrossrefPubMedGoogle Scholar
  • 73 Kootker JA, van Mierlo ML, Hendriks JC. et al. Risk factors for symptoms of depression and anxiety one year poststroke: a longitudinal study. Arch Phys Med Rehabil 2016; 97 (06) 919-928
    CrossrefPubMedGoogle Scholar
  • 74 Afanasiev S, Aharon-Peretz J, Granot M. Personality type as a predictor for depressive symptoms and reduction in quality of life among stroke survivals. Am J Geriatr Psychiatry 2013; 21 (09) 832-839
    CrossrefPubMedGoogle Scholar
  • 75 Wei C, Gao J, Chen L. et al. Factors associated with post-stroke depression and emotional incontinence: lesion location and coping styles. Int J Neurosci 2016; 126 (07) 623-629
    PubMedGoogle Scholar
  • 76 Folstein MF, Maiberger R, McHugh PR. Mood disorder as a specific complication of stroke. J Neurol Neurosurg Psychiatry 1977; 40 (10) 1018-1020
    CrossrefPubMedGoogle Scholar
  • 77 Taylor WD, Aizenstein HJ, Alexopoulos GS. The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry 2013; 18 (09) 963-974
    CrossrefPubMedGoogle Scholar
  • 78 Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M. ‘Vascular depression’ hypothesis. Arch Gen Psychiatry 1997; 54 (10) 915-922
    CrossrefPubMedGoogle Scholar
  • 79 Zeki Al Hazzouri A, Caunca MR, Nobrega JC. et al. Greater depressive symptoms, cognition, and markers of brain aging: Northern Manhattan Study. Neurology 2018; 90 (23) e2077-e2085
    CrossrefPubMedGoogle Scholar
  • 80 Wu R-H, Li Q, Tan Y, Liu X-Y, Huang J. Depression in silent lacunar infarction: a cross-sectional study of its association with location of silent lacunar infarction and vascular risk factors. Neurol Sci 2014; 35 (10) 1553-1559
    CrossrefPubMedGoogle Scholar
  • 81 Santos M, Gold G, Kövari E. et al. Differential impact of lacunes and microvascular lesions on poststroke depression. Stroke 2009; 40 (11) 3557-3562
    CrossrefPubMedGoogle Scholar
  • 82 Villa RF, Ferrari F, Moretti A. Post-stroke depression: mechanisms and pharmacological treatment. Pharmacol Ther 2018; 184: 131-144
    CrossrefPubMedGoogle Scholar
  • 83 Bryer JB, Starkstein SE, Votypka V, Parikh RM, Price TR, Robinson RG. Reduction of CSF monoamine metabolites in poststroke depression: a preliminary report. J Neuropsychiatry Clin Neurosci 1992; 4 (04) 440-442
    CrossrefPubMedGoogle Scholar
  • 84 Cheng S-Y, Zhao Y-D, Li J, Chen X-Y, Wang R-D, Zeng J-W. Plasma levels of glutamate during stroke is associated with development of post-stroke depression. Psychoneuroendocrinology 2014; 47: 126-135
    CrossrefPubMedGoogle Scholar
  • 85 Spalletta G, Bossù P, Ciaramella A, Bria P, Caltagirone C, Robinson RG. The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. Mol Psychiatry 2006; 11 (11) 984-991
    CrossrefPubMedGoogle Scholar
  • 86 Fang M, Zhong L, Jin X. et al. Effect of inflammation on the process of stroke rehabilitation and poststroke depression. Front Psychiatry 2019; 10: 184
    CrossrefPubMedGoogle Scholar
  • 87 Noonan K, Carey LM, Crewther SG. Meta-analyses indicate associations between neuroendocrine activation, deactivation in neurotrophic and neuroimaging markers in depression after stroke. J Stroke Cerebrovasc Dis 2013; 22 (07) e124-e135
    CrossrefPubMedGoogle Scholar
  • 88 Zhang XF, He X, Wu L, Liu C-J, Wu W. Altered functional connectivity of amygdala with the fronto-limbic-striatal circuit in temporal lobe lesion as a proposed mechanism for post-stroke depression. Am J Phys Med Rehabil 2019; 98 (04) 303-310
    CrossrefPubMedGoogle Scholar
  • 89 Kohen R, Cain KC, Mitchell PH. et al. Association of serotonin transporter gene polymorphisms with poststroke depression. Arch Gen Psychiatry 2008; 65 (11) 1296-1302
    CrossrefPubMedGoogle Scholar
  • 90 Guo WY, Zhang ZH, Mu JL. et al. Relationship between 5-HTTLPR polymorphism and post-stroke depression. Genet Mol Res 2016; 15 (01) DOI: 10.4238/gmr.15017460.
    CrossrefPubMedGoogle Scholar
  • 91 Zhao F, Yue Y, Jiang H, Yuan Y. Shared genetic risk factors for depression and stroke. Prog Neuropsychopharmacol Biol Psychiatry 2019; 93: 55-70
    CrossrefPubMedGoogle Scholar
  • 92 Dong JY, Zhang YH, Tong J, Qin LQ. Depression and risk of stroke: a meta-analysis of prospective studies. Stroke 2012; 43 (01) 32-37
    CrossrefPubMedGoogle Scholar
  • 93 Anderson CS, Hackett ML, House AO. Interventions for preventing depression after stroke. Cochrane Database Syst Rev 2004; (02) CD003689
    PubMedGoogle Scholar
  • 94 Deng L, Qiu S, Yang Y. et al. Efficacy and tolerability of pharmacotherapy for post-stroke depression: a network meta-analysis. Oncotarget 2018; 9 (34) 23718-23728
    CrossrefPubMedGoogle Scholar
  • 95 Qin B, Chen H, Gao W. et al. Efficacy, acceptability, and tolerability of antidepressant treatments for patients with post-stroke depression: a network meta-analysis. Braz J Med Biol Res 2018; 51 (07) e7218
    CrossrefPubMedGoogle Scholar
  • 96 Sun Y, Liang Y, Jiao Y. et al. Comparative efficacy and acceptability of antidepressant treatment in poststroke depression: a multiple-treatments meta-analysis. BMJ Open 2017; 7 (08) e016499
    CrossrefPubMedGoogle Scholar
  • 97 Feng R, Wang P, Gao C. et al. Effect of sertraline in the treatment and prevention of poststroke depression: a meta-analysis. Medicine (Baltimore) 2018; 97 (49) e13453
    CrossrefPubMedGoogle Scholar
  • 98 Karaiskos D, Tzavellas E, Spengos K, Vassilopoulou S, Paparrigopoulos T. Duloxetine versus citalopram and sertraline in the treatment of poststroke depression, anxiety, and fatigue. J Neuropsychiatry Clin Neurosci 2012; 24 (03) 349-353
    CrossrefPubMedGoogle Scholar
  • 99 Grade C, Redford B, Chrostowski J, Toussaint L, Blackwell B. Methylphenidate in early poststroke recovery: a double-blind, placebo-controlled study. Arch Phys Med Rehabil 1998; 79 (09) 1047-1050
    CrossrefPubMedGoogle Scholar
  • 100 Delbari A, Salman-Roghani R, Lokk J. Effect of methylphenidate and/or levodopa combined with physiotherapy on mood and cognition after stroke: a randomized, double-blind, placebo-controlled trial. Eur Neurol 2011; 66 (01) 7-13
    CrossrefPubMedGoogle Scholar
  • 101 Laporte S, Chapelle C, Caillet P. et al. Bleeding risk under selective serotonin reuptake inhibitor (SSRI) antidepressants: a meta-analysis of observational studies. Pharmacol Res 2017; 118: 19-32
    CrossrefPubMedGoogle Scholar
  • 102 Wang M-T, Chu C-L, Yeh C-B, Chang L-C, Malone DC, Liou J-T. Antidepressant use and risk of recurrent stroke: a population-based nested case-control study. J Clin Psychiatry 2015; 76 (07) e877-e885
    CrossrefPubMedGoogle Scholar
  • 103 Hackett ML, Anderson CS, House A, Xia J. Interventions for treating depression after stroke. Cochrane Database Syst Rev 2008; (04) CD003437
    PubMedGoogle Scholar
  • 104 Mitchell PH, Veith RC, Becker KJ. et al. Brief psychosocial-behavioral intervention with antidepressant reduces poststroke depression significantly more than usual care with antidepressant: living well with stroke: randomized, controlled trial. Stroke 2009; 40 (09) 3073-3078
    CrossrefPubMedGoogle Scholar
  • 105 Kirkness CJ, Cain KC, Becker KJ. et al. Randomized trial of telephone versus in-person delivery of a brief psychosocial intervention in post-stroke depression. BMC Res Notes 2017; 10 (01) 500
    CrossrefPubMedGoogle Scholar
  • 106 Thomas SA, Walker MF, Macniven JA, Haworth H, Lincoln NB. Communication and Low Mood (CALM): a randomized controlled trial of behavioural therapy for stroke patients with aphasia. Clin Rehabil 2013; 27 (05) 398-408
    CrossrefPubMedGoogle Scholar
  • 107 Jorge RE, Robinson RG, Tateno A. et al. Repetitive transcranial magnetic stimulation as treatment of poststroke depression: a preliminary study. Biol Psychiatry 2004; 55 (04) 398-405
    CrossrefPubMedGoogle Scholar
  • 108 Bucur M, Papagno C. A systematic review of noninvasive brain stimulation for post-stroke depression. J Affect Disord 2018; 238: 69-78
    CrossrefPubMedGoogle Scholar
  • 109 Murray GB, Shea V, Conn DK. Electroconvulsive therapy for poststroke depression. J Clin Psychiatry 1986; 47 (05) 258-260
    PubMedGoogle Scholar
  • 110 Currier MB, Murray GB, Welch CC. Electroconvulsive therapy for post-stroke depressed geriatric patients. J Neuropsychiatry Clin Neurosci 1992; 4 (02) 140-144
    CrossrefPubMedGoogle Scholar
  • 111 Salter KL, Foley NC, Zhu L, Jutai JW, Teasell RW. Prevention of poststroke depression: does prophylactic pharmacotherapy work?. J Stroke Cerebrovasc Dis 2013; 22 (08) 1243-1251
    CrossrefPubMedGoogle Scholar
  • 112 Dennis M, Mead G, Forbes J. et al; FOCUS Trial Collaboration. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. Lancet 2019; 393 (10168): 265-274
    CrossrefPubMedGoogle Scholar
  • 113 Lees R, Fearon P, Harrison JK, Broomfield NM, Quinn TJ. Cognitive and mood assessment in stroke research: focused review of contemporary studies. Stroke 2012; 43 (06) 1678-1680
    CrossrefPubMedGoogle Scholar
  • 114 Chun H-YY, Whiteley WN, Dennis MS, Mead GE, Carson AJ. Anxiety after stroke: the importance of subtyping. Stroke 2018; 49 (03) 556-564
    CrossrefPubMedGoogle Scholar
  • 115 Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67 (06) 361-370
    CrossrefPubMedGoogle Scholar
  • 116 Campbell Burton CA, Murray J, Holmes J, Astin F, Greenwood D, Knapp P. Frequency of anxiety after stroke: a systematic review and meta-analysis of observational studies. Int J Stroke 2013; 8 (07) 545-559
    CrossrefPubMedGoogle Scholar
  • 117 Cumming TB, Blomstrand C, Skoog I, Linden T. The high prevalence of anxiety disorders after stroke. Am J Geriatr Psychiatry 2016; 24 (02) 154-160
    CrossrefPubMedGoogle Scholar
  • 118 Rafsten L, Danielsson A, Sunnerhagen KS. Anxiety after stroke: a systematic review and meta-analysis. J Rehabil Med 2018; 50 (09) 769-778
    CrossrefPubMedGoogle Scholar
  • 119 Kim J-T, Park M-S, Yoon G-J. et al. White matter hyperintensity as a factor associated with delayed mood disorders in patients with acute ischemic stroke. Eur Neurol 2011; 66 (06) 343-349
    CrossrefPubMedGoogle Scholar
  • 120 Fure B, Wyller TB, Engedal K, Thommessen B. Emotional symptoms in acute ischemic stroke. Int J Geriatr Psychiatry 2006; 21 (04) 382-387
    CrossrefPubMedGoogle Scholar
  • 121 Leppävuori A, Pohjasvaara T, Vataja R, Kaste M, Erkinjuntti T. Generalized anxiety disorders three to four months after ischemic stroke. Cerebrovasc Dis 2003; 16 (03) 257-264
    CrossrefPubMedGoogle Scholar
  • 122 Barker-Collo SL. Depression and anxiety 3 months post stroke: prevalence and correlates. Arch Clin Neuropsychol 2007; 22 (04) 519-531
    CrossrefPubMedGoogle Scholar
  • 123 Sagen U, Finset A, Moum T. et al. Early detection of patients at risk for anxiety, depression and apathy after stroke. Gen Hosp Psychiatry 2010; 32 (01) 80-85
    CrossrefPubMedGoogle Scholar
  • 124 Schultz SK, Castillo CS, Kosier JT, Robinson RG. Generalized anxiety and depression. Assessment over 2 years after stroke. Am J Geriatr Psychiatry 1997; 5 (03) 229-237
    CrossrefPubMedGoogle Scholar
  • 125 Tang WK, Chen Y, Lu J. et al. Frontal infarcts and anxiety in stroke. Stroke 2012; 43 (05) 1426-1428
    CrossrefPubMedGoogle Scholar
  • 126 Roppongi T, Nakamura M, Asami T. et al. Posterior orbitofrontal sulcogyral pattern associated with orbitofrontal cortex volume reduction and anxiety trait in panic disorder. Psychiatry Clin Neurosci 2010; 64 (03) 318-326
    CrossrefPubMedGoogle Scholar
  • 127 Huey ED, Lee S, Brickman AM. et al. Neuropsychiatric effects of neurodegeneration of the medial versus lateral ventral prefrontal cortex in humans. Cortex 2015; 73: 1-9
    CrossrefPubMedGoogle Scholar
  • 128 Castillo CS, Schultz SK, Robinson RG. Clinical correlates of early-onset and late-onset poststroke generalized anxiety. Am J Psychiatry 1995; 152 (08) 1174-1179
    CrossrefPubMedGoogle Scholar
  • 129 Schoene D, Heller C, Aung YN, Sieber CC, Kemmler W, Freiberger E. A systematic review on the influence of fear of falling on quality of life in older people: is there a role for falls?. Clin Interv Aging 2019; 14: 701-719
    CrossrefPubMedGoogle Scholar
  • 130 Goh H-T, Nadarajah M, Hamzah NB, Varadan P, Tan MP. Falls and fear of falling after stroke: a case-control study. PM R 2016; 8 (12) 1173-1180
    CrossrefPubMedGoogle Scholar
  • 131 Knapp P, Campbell Burton CA, Holmes J. et al. Interventions for treating anxiety after stroke. Cochrane Database Syst Rev 2017; 5: CD008860
    PubMedGoogle Scholar
  • 132 Golding K, Kneebone I, Fife-Schaw C. Self-help relaxation for post-stroke anxiety: a randomised, controlled pilot study. Clin Rehabil 2016; 30 (02) 174-180
    CrossrefPubMedGoogle Scholar
  • 133 Liu TW, Ng GYF, Chung RCK, Ng SSM. Cognitive behavioural therapy for fear of falling and balance among older people: a systematic review and meta-analysis. Age Ageing 2018; 47 (04) 520-527
    CrossrefPubMedGoogle Scholar
  • 134 Liu TW, Ng GYF, Chung RCK, Ng SSM. Decreasing fear of falling in chronic stroke survivors through cognitive behavior therapy and task-oriented training. Stroke 2018; 50 (01) A118022406
    PubMedGoogle Scholar
  • 135 Zuo W, Yan H, Chunling X. et al. A clinical trial of paroxetine and psychotherapy in patients with poststroke depression and anxiety. Chinese Ment Heal J 2005; 19 (08) 564-566
    PubMedGoogle Scholar
  • 136 Zhang Y-X, Zhang H-L, Wang H. Effects of buspirone hydrochloride on post-stroke affective disorder and neural function. Zhongguo Linchuang Kangfu 2005; 9 (12 CC-Stroke): 8-9
    PubMedGoogle Scholar
  • 137 Stein MB, Sareen J. Clinical practice. Generalized anxiety disorder. N Engl J Med 2015; 373 (21) 2059-2068
    CrossrefPubMedGoogle Scholar
  • 138 Wolitzky-Taylor KB, Horowitz JD, Powers MB, Telch MJ. Psychological approaches in the treatment of specific phobias: a meta-analysis. Clin Psychol Rev 2008; 28 (06) 1021-1037
    CrossrefPubMedGoogle Scholar
  • 139 Weiss DS, Marmar CR. The impact of event scale—revised. In: Wilson JP, Keane TM. Assessing Psychological Trauma and PTSD: A Practitioner's Handbook. American Psychological Association. Washington, DC: 1997: 399-411
    Google Scholar
  • 140 Blanchard EB, Jones-Alexander J, Buckley TC, Forneris CA. Psychometric properties of the PTSD Checklist (PCL). Behav Res Ther 1996; 34 (08) 669-673
    CrossrefPubMedGoogle Scholar
  • 141 Sembi S, Tarrier N, O'Neill P, Burns A, Faragher B. Does post-traumatic stress disorder occur after stroke: a preliminary study. Int J Geriatr Psychiatry 1998; 13 (05) 315-322
    CrossrefPubMedGoogle Scholar
  • 142 Jiang C. Posttraumatic stress disorder after a first-ever intracerebral hemorrhage in the Chinese population: a pilot study. Appl Neuropsychol Adult 2020; 27 (01) 1-8
    CrossrefPubMedGoogle Scholar
  • 143 Favrole P, Jehel L, Levy P. et al. Frequency and predictors of post-traumatic stress disorder after stroke: a pilot study. J Neurol Sci 2013; 327 (1-2): 35-40
    CrossrefPubMedGoogle Scholar
  • 144 Hedlund M, Zetterling M, Ronne-Engström E, Carlsson M, Ekselius L. Depression and post-traumatic stress disorder after aneurysmal subarachnoid haemorrhage in relation to lifetime psychiatric morbidity. Br J Neurosurg 2011; 25 (06) 693-700
    CrossrefPubMedGoogle Scholar
  • 145 Wang X, Chung MC, Hyland ME, Bahkeit M. Posttraumatic stress disorder and psychiatric co-morbidity following stroke: the role of alexithymia. Psychiatry Res 2011; 188 (01) 51-57
    CrossrefPubMedGoogle Scholar
  • 146 Bruggimann L, Annoni JM, Staub F, von Steinbüchel N, Van der Linden M, Bogousslavsky J. Chronic posttraumatic stress symptoms after nonsevere stroke. Neurology 2006; 66 (04) 513-516
    CrossrefPubMedGoogle Scholar
  • 147 Visser-Meily JM, Rinkel GJ, Vergouwen MD, Passier PE, van Zandvoort MJ, Post MW. Post-traumatic stress disorder in patients 3 years after aneurysmal subarachnoid haemorrhage. Cerebrovasc Dis 2013; 36 (02) 126-130
    CrossrefPubMedGoogle Scholar
  • 148 Baisch SB, Schenk T, Noble AJ. What is the cause of post-traumatic stress disorder following subarachnoid haemorrhage? Post-ictal events are key. Acta Neurochir (Wien) 2011; 153 (04) 913-922
    CrossrefPubMedGoogle Scholar
  • 149 Edmondson D, Richardson S, Fausett JK, Falzon L, Howard VJ, Kronish IM. Prevalence of PTSD in survivors of stroke and transient ischemic attack: a meta-analytic review. PLoS One 2013; 8 (06) e66435
    CrossrefPubMedGoogle Scholar
  • 150 Breslau N. The epidemiology of trauma, PTSD, and other posttrauma disorders. Trauma Violence Abuse 2009; 10 (03) 198-210
    CrossrefPubMedGoogle Scholar
  • 151 Speck V, Noble A, Kollmar R, Schenk T. Diagnosis of spontaneous cervical artery dissection may be associated with increased prevalence of posttraumatic stress disorder. J Stroke Cerebrovasc Dis 2014; 23 (02) 335-342
    CrossrefPubMedGoogle Scholar
  • 152 Goldfinger JZ, Edmondson D, Kronish IM. et al. Correlates of post-traumatic stress disorder in stroke survivors. J Stroke Cerebrovasc Dis 2014; 23 (05) 1099-1105
    CrossrefPubMedGoogle Scholar
  • 153 Kiphuth IC, Utz KS, Noble AJ, Köhrmann M, Schenk T. Increased prevalence of posttraumatic stress disorder in patients after transient ischemic attack. Stroke 2014; 45 (11) 3360-3366
    CrossrefPubMedGoogle Scholar
  • 154 Favrole P, Jehel L, Levy P. et al. Frequency and predictors of post-traumatic stress disorder after stroke: a pilot study. J Neurol Sci 2013; 327 (1-2): 35-40
    CrossrefPubMedGoogle Scholar
  • 155 Letamendia C, Leblanc NJ, Pariente J. et al. Peritraumatic distress predicts acute posttraumatic stress disorder symptoms after a first stroke. Gen Hosp Psychiatry 2012; 34 (05) e11-e13
    CrossrefPubMedGoogle Scholar
  • 156 Utz KS, Kiphuth IC, Schenk T. Posttraumatic stress disorder in patients after transient ischemic attack: a one-year follow-up. J Psychosom Res 2019; 122: 36-38
    CrossrefPubMedGoogle Scholar
  • 157 Guideline Development Panel for the Treatment of PTSD in Adults, American Psychological Association. Summary of the clinical practice guideline for the treatment of posttraumatic stress disorder (PTSD) in adults. Am Psychol 2019; 74 (05) 596-607
    CrossrefPubMedGoogle Scholar
  • 158 Forman-Hoffman V, Middleton JC, Feltner C. et al. Psychological and Pharmacological Treatments for Adults with Posttraumatic Stress Disorder: A Systematic Review Update. Agency for Healthcare Research and Quality (US). 2018
    CrossrefGoogle Scholar
  • 159 El-Solh AA. Management of nightmares in patients with posttraumatic stress disorder: current perspectives. Nat Sci Sleep 2018; 10: 409-420
    CrossrefPubMedGoogle Scholar
  • 160 Garton AL, Sisti JA, Gupta VP, Christophe BR, Connolly S. Post-stroke posttraumatic stress disorder: a review. Stroke 2017; 48 (02) 507-512
    CrossrefPubMedGoogle Scholar
  • 161 Kronish IM, Edmondson D, Goldfinger JZ, Fei K, Horowitz CR. Posttraumatic stress disorder and adherence to medications in survivors of strokes and transient ischemic attacks. Stroke 2012; 43 (08) 2192-2197
    CrossrefPubMedGoogle Scholar
  • 162 Stanton BR, Carson A. Apathy: a practical guide for neurologists. Pract Neurol 2016; 16 (01) 42-47
    CrossrefPubMedGoogle Scholar
  • 163 van Dalen JW, Moll van Charante EP, Nederkoorn PJ, van Gool WA, Richard E. Poststroke apathy. Stroke 2013; 44 (03) 851-860
    CrossrefPubMedGoogle Scholar
  • 164 Caeiro L, Ferro JM, Costa J. Apathy secondary to stroke: a systematic review and meta-analysis. Cerebrovasc Dis 2013; 35 (01) 23-39
    CrossrefPubMedGoogle Scholar
  • 165 Douven E, Köhler S, Rodriguez MMF, Staals J, Verhey FRJ, Aalten P. Imaging markers of post-stroke depression and apathy: a systematic review and meta-analysis. Neuropsychol Rev 2017; 27 (03) 202-219
    CrossrefPubMedGoogle Scholar
  • 166 Tang WK, Wong L, Mok V, Chu W, Wang DF. Apathy after stroke: potential risk factors and magnetic resonance imaging markers. Hong Kong Med J 2018; 24 (Suppl. 03) 18-20
    PubMedGoogle Scholar
  • 167 Kohno N, Abe S, Toyoda G, Oguro H, Bokura H, Yamaguchi S. Successful treatment of post-stroke apathy by the dopamine receptor agonist ropinirole. J Clin Neurosci 2010; 17 (06) 804-806
    CrossrefPubMedGoogle Scholar
  • 168 Aragona B, De Luca R, Piccolo A. et al. Is bupropion useful in the treatment of post-stroke thalamic apathy? A case report and considerations. Funct Neurol 2018; 33 (04) 213-216
    PubMedGoogle Scholar
  • 169 Spiegel DR, Kim J, Greene K, Conner C, Zamfir D. Apathy due to cerebrovascular accidents successfully treated with methylphenidate: a case series. J Neuropsychiatry Clin Neurosci 2009; 21 (02) 216-219
    CrossrefPubMedGoogle Scholar
  • 170 Robinson RG, Jorge RE, Clarence-Smith K, Starkstein S. Double-blind treatment of apathy in patients with poststroke depression using nefiracetam. J Neuropsychiatry Clin Neurosci 2009; 21 (02) 144-151
    CrossrefPubMedGoogle Scholar
  • 171 Starkstein SE, Brockman S, Hatch KK. et al. A randomized, placebo-controlled, double-blind efficacy study of nefiracetam to treat poststroke apathy. J Stroke Cerebrovasc Dis 2016; 25 (05) 1119-1127
    CrossrefPubMedGoogle Scholar
  • 172 Chen L, Xiong S, Liu Y. et al. Comparison of motor relearning program versus Bobath approach for prevention of poststroke apathy: a randomized controlled trial. J Stroke Cerebrovasc Dis 2019; 28 (03) 655-664
    CrossrefPubMedGoogle Scholar
  • 173 Theleritis C, Siarkos K, Politis AA, Katirtzoglou E, Politis A. A systematic review of non-pharmacological treatments for apathy in dementia. Int J Geriatr Psychiatry 2018; 33 (02) e177-e192
    CrossrefPubMedGoogle Scholar
  • 174 Glader E-L, Stegmayr B, Asplund K. Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden. Stroke 2002; 33 (05) 1327-1333
    CrossrefPubMedGoogle Scholar
  • 175 Brodtmann A, van de Port IGL. Fitness, depression, and poststroke fatigue: worn out or weary?. Neurology 2013; 81 (18) 1566-1567
    CrossrefPubMedGoogle Scholar
  • 176 Hinkle JL, Becker KJ, Kim JS. et al; American Heart Association Council on Cardiovascular and Stroke Nursing and Stroke Council. Poststroke Fatigue: Emerging Evidence and Approaches to Management: a scientific statement for healthcare professionals from the American Heart Association. Stroke 2017; 48 (07) e159-e170
    CrossrefPubMedGoogle Scholar
  • 177 De Doncker W, Dantzer R, Ormstad H, Kuppuswamy A. Mechanisms of poststroke fatigue. J Neurol Neurosurg Psychiatry 2018; 89 (03) 287-293
    CrossrefPubMedGoogle Scholar
  • 178 Tang WK, Chen YK, Mok V. et al. Acute basal ganglia infarcts in poststroke fatigue: an MRI study. J Neurol 2010; 257 (02) 178-182
    CrossrefPubMedGoogle Scholar
  • 179 Tang WK, Liang HJ, Chen YK. et al. Poststroke fatigue is associated with caudate infarcts. J Neurol Sci 2013; 324 (1-2): 131-135
    CrossrefPubMedGoogle Scholar
  • 180 Kuppuswamy A, Clark EV, Turner IF, Rothwell JC, Ward NS. Post-stroke fatigue: a deficit in corticomotor excitability?. Brain 2015; 138 (Pt 1): 136-148
    CrossrefPubMedGoogle Scholar
  • 181 Douven E, Köhler S, Schievink SHJ. et al. Temporal associations between fatigue, depression, and apathy after stroke: results of the cognition and affect after stroke, a prospective evaluation of risks study. Cerebrovasc Dis 2017; 44 (5-6): 330-337
    CrossrefPubMedGoogle Scholar
  • 182 Bivard A, Lillicrap T, Krishnamurthy V. et al. MIDAS (modafinil in debilitating fatigue after stroke): a randomized, double-blind, placebo-controlled, cross-over trial. Stroke 2017; 48 (05) 1293-1298
    CrossrefPubMedGoogle Scholar
  • 183 Kim JS. Post-stroke mood and emotional disturbances: pharmacological therapy based on mechanisms. J Stroke 2016; 18 (03) 244-255
    CrossrefPubMedGoogle Scholar
  • 184 House A, Dennis M, Molyneux A, Warlow C, Hawton K. Emotionalism after stroke. BMJ 1989; 298 (6679): 991-994
    CrossrefPubMedGoogle Scholar
  • 185 Kim JS, Choi-Kwon S. Poststroke depression and emotional incontinence: correlation with lesion location. Neurology 2000; 54 (09) 1805-1810
    CrossrefPubMedGoogle Scholar
  • 186 Allida S, Patel K, House A, Hackett ML. Pharmaceutical interventions for emotionalism after stroke. Cochrane Database Syst Rev 2019; 3: CD003690
    PubMedGoogle Scholar
  • 187 Zorowitz RD, Alexander DN, Formella AE, Ledon F, Davis C, Siffert J. Dextromethorphan/Quinidine for pseudobulbar affect following stroke: safety and effectiveness in the PRISM II Trial. PM R 2018; DOI: 10.1016/j.pmrj.2018.06.003. . [Epub ahead of print]
    CrossrefPubMedGoogle Scholar
  • 188 Kim JS, Choi-Kwon S. Poststroke depression and emotional incontinence: correlation with lesion location. Neurology 2002; 54 (09) 1805-1810
    CrossrefPubMedGoogle Scholar
  • 189 Choi-Kwon S, Han K, Cho K-H. et al. Factors associated with post-stroke anger proneness in ischaemic stroke patients. Eur J Neurol 2013; 20 (09) 1305-1310
    CrossrefPubMedGoogle Scholar
  • 190 Kim JS. Management of post-stroke mood and emotional disturbances. Expert Rev Neurother 2017; 17 (12) 1179-1188
    CrossrefPubMedGoogle Scholar
  • 191 Choi-Kwon S, Han SW, Kwon SU, Kang D-W, Choi JM, Kim JS. Fluoxetine treatment in poststroke depression, emotional incontinence, and anger proneness: a double-blind, placebo-controlled study. Stroke 2006; 37 (01) 156-161
    CrossrefPubMedGoogle Scholar
  • 192 Kim JS, Lee E-J, Lee B-C, Kim JS, Lee E-J. Efficacy of early administration of escitalopram on depressive and emotional symptoms and neurological dysfunction after stroke: a multicentre, double-blind, randomised, placebo-controlled study. Lancet Psychiatry 2017; 4 (01) 33-41
    CrossrefPubMedGoogle Scholar
  • 193 Akaho R, Deguchi I, Kigawa H, Nishimura K. Obsessive-compulsive disorder following cerebrovascular accident: a case report and literature review. J Stroke Cerebrovasc Dis 2019; 28 (04) e17-e21
    CrossrefPubMedGoogle Scholar
  • 194 Almeida OP, Xiao J. Mortality associated with incident mental health disorders after stroke. Aust N Z J Psychiatry 2007; 41 (03) 274-281
    CrossrefPubMedGoogle Scholar
  • 195 Cummings JL. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology 1997; 48 (5, Suppl 6): S10-S16
    CrossrefPubMedGoogle Scholar
  • 196 Stangeland H, Orgeta V, Bell V. Poststroke psychosis: a systematic review. J Neurol Neurosurg Psychiatry 2018; 89 (08) 879-885
    CrossrefPubMedGoogle Scholar
  • 197 Goldstein LB, Bullman S. Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats. Neurorehabil Neural Repair 2002; 16 (04) 321-325
    CrossrefPubMedGoogle Scholar
  • 198 Conroy B, Zorowitz R, Horn SD, Ryser DK, Teraoka J, Smout RJ. An exploration of central nervous system medication use and outcomes in stroke rehabilitation. Arch Phys Med Rehabil 2005; 86 (12, Suppl 2): S73-S81
    CrossrefPubMedGoogle Scholar
  • 199 Santos CO, Caeiro L, Ferro JM, Figueira ML. Mania and stroke: a systematic review. Cerebrovasc Dis 2011; 32 (01) 11-21
    CrossrefPubMedGoogle Scholar
  • 200 Ferro JM. Neuropsychiatric sequelae of stroke. 2016 Accessed February 2, 2020 at: https://www.nature.com/articles/nrneurol.2016.46
    Google Scholar
  • 201 Liu CY, Wang SJ, Fuh JL, Yang YY, Liu HC. Bipolar disorder following a stroke involving the left hemisphere. Aust N Z J Psychiatry 1996; 30 (05) 688-691
    CrossrefPubMedGoogle Scholar
  • 202 Fenn D, George K. Post-stroke mania late in life involving the left hemisphere. Aust N Z J Psychiatry 1999; 33 (04) 598-600
    CrossrefPubMedGoogle Scholar
  • 203 Nagaratnam N, Wong K-K, Patel I. Secondary mania of vascular origin in elderly patients: a report of two clinical cases. Arch Gerontol Geriatr 2006; 43 (02) 223-232
    CrossrefPubMedGoogle Scholar
  • 204 Cummings JL. Neuropsychiatric manifestations of right hemisphere lesions. Brain Lang 1997; 57 (01) 22-37
    CrossrefPubMedGoogle Scholar
  • 205 Satzer D, Bond DJ. Mania secondary to focal brain lesions: implications for understanding the functional neuroanatomy of bipolar disorder. Bipolar Disord 2016; 18 (03) 205-220
    CrossrefPubMedGoogle Scholar
  • 206 Podawiltz A. A review of current bipolar disorder treatment guidelines. J Clin Psychiatry 2012; 73 (03) e12
    CrossrefPubMedGoogle Scholar
  • 207 Lan C-C, Liu C-C, Lin C-H. et al. A reduced risk of stroke with lithium exposure in bipolar disorder: a population-based retrospective cohort study. Bipolar Disord 2015; 17 (07) 705-714
    CrossrefPubMedGoogle Scholar