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Thromb Haemost 1984; 52(03): 301-304
DOI: 10.1055/s-0038-1661200
Original Article
Schattauer GmbH Stuttgart

High Fibrinopeptide A (FPA) Levels in Acute Non-Lymphocytic Leukemia Are Reduced by Heparin Administration

L Gugliotta
The L. and A. Seràgnoli Institute of Hematology, University of Bologna and the Hemophilia and Thrombosis Centre, A. Bianchi Bonomi, University of Milano, Italy
,
Silvana Viganò
The L. and A. Seràgnoli Institute of Hematology, University of Bologna and the Hemophilia and Thrombosis Centre, A. Bianchi Bonomi, University of Milano, Italy
,
A D’Angelo
The L. and A. Seràgnoli Institute of Hematology, University of Bologna and the Hemophilia and Thrombosis Centre, A. Bianchi Bonomi, University of Milano, Italy
,
Anna Guarini
The L. and A. Seràgnoli Institute of Hematology, University of Bologna and the Hemophilia and Thrombosis Centre, A. Bianchi Bonomi, University of Milano, Italy
,
S Tura
The L. and A. Seràgnoli Institute of Hematology, University of Bologna and the Hemophilia and Thrombosis Centre, A. Bianchi Bonomi, University of Milano, Italy
,
P M Mannucci
The L. and A. Seràgnoli Institute of Hematology, University of Bologna and the Hemophilia and Thrombosis Centre, A. Bianchi Bonomi, University of Milano, Italy
› Author Affiliations
Further Information

Publication History

Received 18 June 1984

Accepted 24 September 1984

Publication Date:
19 July 2018 (online)

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Summary

Plasma levels of fibrinopeptide A (FPA) in 30 untreated patients with acute non-lymphocytic leukemia (ANLL) were significantly higher than in 30 healthy controls (p <0.001). Patients without laboratory signs of disseminated intravascular coagulation (DIC) had levels of FPA higher than controls (p <0.02) but markedly lower than patients with DIC (p <0.001). Five patients with M3 leukemia had a higher mean FPA level (p <0.02) and a lower peripheral blast cell count (p <0.05) than patients with other cytological subtypes of ANLL. When patients with M3 were excluded, a significant correlation was observed between the peripheral blast cell counts and the FPA levels (r = 0.66, p <0.001). FPA levels were similar with body temperature either above or below 38° C. After intravenous bolus of heparin FPA dropped to normal levels in 14 out of 17 patients who had high baseline values. These findings indicate that intravascular thrombin formation, which probably result from the expression of procoagulant activities of blast cells, is the main cause of high FPA in the majority of patients with acute non-lymphocytic leukemia.

Key words

Fibrinopeptide A (FPA) - Acute leukemia - Heparin
 

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