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Hamostaseologie 1988; 08(04): 173-182
DOI: 10.1055/s-0038-1659923
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Thrombogenese und Hämodynamik

L. J. Wurzinger
1   Anatomisches Institut der Technischen Universität München
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Publication Date:
25 June 2018 (online)

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Zusammenfassung

Die in enger Kooperation von medizinisch-theoretischen (Anatomie, Physiologie) und ingenieurwissen-schaftlichen (Aerodynamisches Institut) Disziplinen an der RWTH Aachen erarbeiteten Befunde zeigen, daß nur jeweils ein verschwindend kleiner Anteil von Plättchen (und anderen Blutzellen) im alternden bzw. atherosklerotisch vorgeschädigten Kreislauf Bereiche kritischer Strömungskräfte durchläuft, von denen wiederum nur ein geringer Prozentsatz irreversibel geschädigt wird. Obwohl dieses Trauma grundsätzlich einen auslösenden Reiz auf das Hämo-stasesystem darstellt, erfordern die nachgeschalteten zellbiologischen und biochemischen Verstärkerschritte gänzlich andere fluiddynamische Bedingungen, als sie in schneller, ungestörter Rohrströmung gegeben sind. Die Manifestation und Lokalisation des Thrombus scheint von fluiddyna-misch abgeschlossenen Rezirkula-tionsgebieten bestimmt zu sein.

 

  • Literatur

  • 1 Colman R.W, Hirsh J, Marder V.J, Salzman E.W. (Eds) Hemostasis and Thrombosis. Philadelphia: Lippincott; 1982
    Google Scholar
  • 2 Zwaal R.F.A, Comfurius P, van Deenen L.L.M. Membrane asymmetry and blood coagulation. Nature 1977; 268: 358.
    CrossrefPubMedGoogle Scholar
  • 3 Grette K. Studies on the mechanism of thrombin catalyzed hemostatic reactions in blood platelets. Acta Physiol Scand 1962; 56: 9.
    PubMedGoogle Scholar
  • 4 Schmid-Schönbein H, Wurzinger L.J, Zimmermann R.E. (Eds) Enzyme Activation in Blood-Perfused Artificial Organs. Dordrecht: Martinus Nijhoff; 1985
    Google Scholar
  • 5 Moneada S.R, Gryglewski R, Bunting S. et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976; 263: 663.
    CrossrefPubMedGoogle Scholar
  • 6 Marlar R.A, Kleiss A.J, Griffin J.H. Mechanism of action of human activated protein C a thrombin-dependent anticoagulant enzyme. Blood 1982; 59: 1067-72.
    PubMedGoogle Scholar
  • 7 Nerem R.M, Levesque M. Fluid dynamics as a factor in the localization of atherogene-sis. Ann NY Acad Sci 1983; 416: 709-17.
    CrossrefPubMedGoogle Scholar
  • 8 Murphy E.A, Rowsell H.C, Downie H.G. et al. Encrustation and atherosclerosis: the analogy between early in vivo lesions and deposits which occur in extracorporeal circulations. Canad Med Ass J 1962; 87: 259.
    PubMedGoogle Scholar
  • 9 Hugh A.E, Fox A. The precise localization of atheroma and its association with stasis at the origin of the internal carotid artery – a radiographic investigation. Br J Radiol 1970; 43: 377.
    CrossrefPubMedGoogle Scholar
  • 10 Fry D.L. Hemodynamic forces in atheroge-nesis. In: Cerebral Vascular Diseases. Scheinberg P. (Ed) New York : Raven Press; 1976: 77.
    Google Scholar
  • 11 Heliums J.D, Hardwick R.A. Response of platelets to shear stress – a review. In: Gross D.R, Hwang N.H.C. (Eds) The Rheology of Blood, Blood Vessels and Associated Tissues. Amsterdam : Sijhoff and Noordhoff; 1981: 160.
    Google Scholar
  • 12 Holmsen H. Prostaglandin endoperoxide-thromboxane synthesis and dense granula secretion as positive feedback loops in the propagation of platelet responses during »the basic platelet reaction«. Thromb Haemostas 1977; 38: 1030-41.
    PubMedGoogle Scholar
  • 13 Heuser G, Opitz R. A Couette viscometer for short time shearing of blood. Biorheology 1980; 17: 17.
    CrossrefPubMedGoogle Scholar
  • 14 Anderson G.H, Heliums J.D, Moake J.L. et al. Platelet lysis and aggregation in shear fields. Blood Cells 1978; 4: 499.
    PubMedGoogle Scholar
  • 15 Stevens D.E, Joist J.H, Sutern S.P. Role of platelet-prostaglandin synthesis in shear-induced platelet alterations. Blood 1980; 56: 753-58.
    PubMedGoogle Scholar
  • 16 Joist J.H, Baker R.K. Loss of 111Indium as indicator of platelet injury. Blood 1981; 58: 350-3.
    PubMedGoogle Scholar
  • 17 Petschek H.E, Adamis D, Kantrowitz A.R. Stagnation point flow thrombus formation. Trans Am Soc Artif Int Organs 1968; 14: 256-62.
    PubMedGoogle Scholar
  • 18 Wurzinger L.J, Blasberg P, Horii F. et al. A stagnation point flow technique to measure platelet adhesion onto polymer films from native blood – a technical report. Thromb Res 1986; 44: 401-6.
    CrossrefPubMedGoogle Scholar
  • 19 Anderson G.H, Heliums J.D, Moake J.L. et al. Platelet response to shear stress: changes in serotonin uptake, serotinin release and ADP induced aggregation. Thromb Res. 1978; 13: 1039-47.
    CrossrefPubMedGoogle Scholar
  • 20 Zwaal R.F.A, Rosing J, Tans G. et al. Topological and kinetic aspects of phospholipids in blood coagulation. In: Mann K.G, Taylor F.B. (Eds) The Regulation of Coagulation. Amsterdam: Elsevier; 1980: 95.
    Google Scholar
  • 21 Ugurbil K, Holmsen H, Shulman R.G. Adenine nucleotide storage and secretion in platelets as studied by 31P nuclear magnetic resonance. Proc Natl Acad Sci USA 1979; 75: 2227.
    PubMedGoogle Scholar
  • 22 Wurzinger L.J, Opitz R, Wolf M. et al. Ultrastructural investigations on the question of mechanical activation of blood platelets. Blut 1987; 54: 97-107.
    CrossrefPubMedGoogle Scholar
  • 23 Turitto V.T, Baumgartner H.R. Platelet interaction with subendothelium in a perfusion system: physical role of red blood cells. Microvasc Res 1975; 9: 335.
    CrossrefPubMedGoogle Scholar
  • 24 Blasberg P, Wurzinger L.J, Schmid-Schönbein H. Microrheology of thrombocyte deposition: effect of stimulation, flow direction, and red cells. In: Schettler G, Nerem R.M, Schmid-Schönbein H, Morl H, Diehm C. (Eds) Fluid Dynamics as a Localizing Factor for Atherosclerosis. Heidelberg: Springer; 1983: 103.
    CrossrefGoogle Scholar
  • 25 Bergqvist D, Arfors K.E. Haemostatic platelet plug formation in the isolated rabbit mesenteric preparation – an analysis of red blood cell participation. Thromb Haemostas 1980; 44: 6-8.
    PubMedGoogle Scholar
  • 26 Reimers R.C, Sutera S.P, Joist J.H. Potentiation by red blood cells of shear-induced platelet aggregation: relative importance of chemical and physical mechanisms. Blood 1984; 64: 1200-6.
    PubMedGoogle Scholar
  • 27 Duhm J, Deuticke B, Gerlach E. 2,3-Di-phosphoglycerat – Stoffwechsel und Glukose in Menschen – Erythrozyten. Einfluß von Sulfat, Tetrathionat und Disulfit. Hoppe-Seyler’s Z Physiol Chem 1969; 350: 1008.
    PubMedGoogle Scholar
  • 28 Baldauf W, Wurzinger L.J, Kinder J. The role of stagnation point flow in the formation of platelet thrombi on glass surfaces in tubes with various geometry. Path Res Pract 1978; 163: 9.
    CrossrefPubMedGoogle Scholar
  • 29 Nerem R.M, Rumberger J.A, Gross D.R. et al. Hot film coronary artery velocity measurements in horses. Cardiovasc Res 1974; 10: 301.
    PubMedGoogle Scholar
  • 30 Caro C.G, Fitz-Gerald J.M, Schroter R.C. Atheroma and arterial wall shear: observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis. Proc Royal Soc London (Biol) 1971; 177: 109.
    CrossrefPubMedGoogle Scholar
  • 31 Karino T, Motomiya M. Flow visualization in isolated transparent natural blood vessels. Biorheology 1983; 20: 119.
    CrossrefPubMedGoogle Scholar
  • 32 Kratzer M.A.A, Kinder J. Streamline pattern and velocity components of flow in a model of a branching coronary vessel -possible functional implication for the development of localized platelet deposition in vitro. Microvasc Res 1986; 31: 250.
    CrossrefPubMedGoogle Scholar
  • 33 Mustard J.F, Packham M.A, Kinlough-Rathbone R.L. et al. Fibrinogen and ADP-induced platelet aggregation. Blood 1978; 52: 453-66.
    PubMedGoogle Scholar
  • 34 Jaffe E.A, Leung L.L.K, Nachman R.L. et al. Thrombospondin is the endogenous lectin of human platelets. Nature 1982; 295: 246.
    CrossrefPubMedGoogle Scholar
  • 35 Koutts J, Walsh P.N, Plow E.F. et al. Active release of human platelet factor VHI-rela-ted antigen by adenosine diphosphate, collagen, and thrombin. J Clin Invest 1978; 62: 1255.
    CrossrefPubMedGoogle Scholar
  • 36 Wurzinger L.J, Blasberg P, Schmid-Schönbein H. Consolidation of platelet aggregates by fibrin despite heparin anticoagulation. Thromb Haemostas 1981; 46: 666.
    PubMedGoogle Scholar
  • 37 Wurzinger L.J, Herbst K, Schmid-Schönbein H. Influence of platelet aggregate size and heparin concentration on thrombin. In: Breddin H.K, Bender N, Scharf R.E. (Eds). Recent Advances and New Developments in Haemostaseology. Haemostasis, 1986; 16 (Suppl. 05) 78-9.
    PubMedGoogle Scholar
  • 38 Schmid-Schönbein H, Wurzinger L.J. Transport phenomena in pulsating poststenotic vortex flow in arteries – an interactive concept of fluid-dynamical, hemorheologi-cal, and biochemical processes in white thrombus formation. Nouv Rev Fr Hematol 1986; 28: 257-67.
    PubMedGoogle Scholar
  • 39 Wurzinger L.J, Blasberg P, van de Loecht M. et al. Model experiments on platelet adhesion in stagnation point flow. Biorheology 1984; 21: 649.
    CrossrefPubMedGoogle Scholar
  • 40 Reiiiinger A. Platelet microthrombus formation on entothelial monolayers under stagnation point flow in vitro. Hämostasis 1988; 18 (Suppl. 02) 73.
    PubMedGoogle Scholar
  • 41 Maino G, Shea S.M, Leventhal M. Endothelial contraction induced by histamine type mediators. J Cell Biol 1969; 42: 647.
    CrossrefPubMedGoogle Scholar
  • 42 Barnhart M.I, Chen S.T. Endothelial cell physiology, perturbations and responses. Sem Thromb Hemost 1978; 5: 60-86.
    PubMedGoogle Scholar
  • 43 Sabbah H.N, Khaja F, Brymer J.F. et al. Blood flow in the coronary arteries of man: relation to atherosclerosis. In: Liepsch D. (Ed) Blood Flow in Large Arteries: Applications to Atherogenesis and Clinical Medicine. Basel: Karger; (im Druck).
    Google Scholar
  • 44 Meyer J, Erbel R, Pop T. et al. PTCA und intrakoronare Lyse bei akutem Myokardinfarkt. Z Kardiol 1986; 75 (Suppl. 05) 83-91.
    PubMedGoogle Scholar