Download PDF
Thromb Haemost 1983; 49(01): 051-052
DOI: 10.1055/s-0038-1657314
Original Article
Schattauer GmbH Stuttgart

Failure of Salicylate to Reduce Inhibition of Human Venous Prostacyclin in Synthesis by Conventional Dose Aspirin

S P Hanley
The Departments of Medicine and Clinical Chemistry, University Hospital, Nottingham NG7 2UH, U.K.
,
J Hughes
The Departments of Medicine and Clinical Chemistry, University Hospital, Nottingham NG7 2UH, U.K.
› Author Affiliations
Further Information

Publication History

Received 02 November 1982

Accepted 15 December 1982

Publication Date:
18 July 2018 (online)

  PDF Download  Permissions and Reprints

Summary

Ex vivo venous prostacyclin synthesis was measured in 24 patients who received no medication, or a single oral dose of aspirin 300 mg, sodium salicylate, 500 mg, or a combination of sodium salicylate 500 mg followed by aspirin 300 mg 1 1/2 or 3 hr later. Aspirin alone substantially reduced PGI2 synthesis but sodium salicylate alone had no effect. Sodium salicylate administration prior to aspirin did not reverse the inhibitory effect of aspirin on PGI2 synthesis.

Keywords

Aspirin - Salicylate - Prostacyclin
 

  • References

  • 1 Fields WS. Controlled trial of aspirin in cerebral ischaemia. Stroke 1977; 08: 301-315
    CrossrefPubMedGoogle Scholar
  • 2 Steering Committee MRC. Effect of aspirin on post-operative venous thrombosis. Lancet 1972; 02: 441-445
    PubMedGoogle Scholar
  • 3 Elwood PC, Sweetnam PM. Aspirin and secondary mortality after myocardial infarction. Lancet 1979; 02: 1313-1315
    PubMedGoogle Scholar
  • 4 Aspirin Myocardial Infarction Study Group. A randomised controlled trial of aspirin in persons recovered from myocardial infarction. JAMA 1980; 243: 661-669
    CrossrefPubMedGoogle Scholar
  • 5 Burch JW, Baenziger NL, Stanford N, Majerus PW. Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin. Proc Nat Acad Sci 1978; 75: 5181-5184
    CrossrefPubMedGoogle Scholar
  • 6 Baenziger NL, Becherer PR, Majerus PW. Characterisation of prostacyclin synthesis in cultured human arterial smooth muscle cell, venous endothelial cells and skin fibroblasts. Cell 1979; 16: 967-974
    CrossrefPubMedGoogle Scholar
  • 7 Hanley SP, Bevan J, Cockbill SR, Heptinstall S. Differential inhibition by low dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis. Lancet 1981; 01: 969-971
    PubMedGoogle Scholar
  • 8 Merino J, Livio M, Rajtar G, Gaetano GDe. Salicylate reverses in vitro aspirin inhibition of rat platelets and vascular prostaglandin generation. Biochem Pharmacol 1980; 29: 1093-1096
    CrossrefPubMedGoogle Scholar
  • 9 Cerletti C, Livio M, Castellarnau CDe, Dejana E, Gaetano GDe. Salicylate interferes in vivo with aspirin induced inhibition of platelet and vascular prostaglandin generation in rats. Prostaglandins Leukotrienes Med 1982; 08: 263-264
    CrossrefPubMedGoogle Scholar
  • 10 Poyser NL. Development and use of a radioimmunoassay for measuring 6 oxo prostaglandin F1α . Dev Pharmacol 1980; 01: 44-55
    PubMedGoogle Scholar
  • 11 Preston FE, Whipps S, Jackson CA, French AJ, Wyld PJ, Stoddard CJ. Inhibition of prostacyclin synthesis and platelet thromboxane A2after low dose aspirin. N Eng J Med 1981; 304: 76-79
    CrossrefPubMedGoogle Scholar