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Thromb Haemost 1979; 42(05): 1355-1367
DOI: 10.1055/s-0038-1657035
Original Article
Schattauer GmbH Stuttgart

In Vitro Thrombogenicity Tests of Factor IX Concentrates

I. A Survey of Available Assays
C V Prowse
The South-East Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh
,
A Chirnside
The South-East Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh
,
R A Elton
*   Medical Computing and Statistics Unit, Medical School, Edinburgh
The South-East Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh
› Author Affiliations
Further Information

Publication History

Received 09 February 1979

Accepted 21 May 1979

Publication Date:
23 August 2018 (online)

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Summary

Various factor IX concentrates have been examined in a number of in vitro tests of thrombogenicity. The results suggest that some tests are superfluous as in concentrates with activity in any of these tests activation is revealed by a combination of the non-activated partial thromboplastin time, the thrombin (or Xa) generation time and factor VIII inhibitor bypassing activity tests. Assay of individual coagulant enzymes revealed that most concentrates contained more factor IXa than Xa. However only a small number of concentrates, chiefly those that had been purposefully activated, contained appreciable amounts of either enzyme.

 

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