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Hamostaseologie 1990; 10(01): 52-63
DOI: 10.1055/s-0038-1655181
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Schattauer GmbH

Struktur und Biologie von Interleukinen

Der Einfluß von IL-1 und TNFα auf Endothelzellen und das Gerinnungssystem
D. Brazel
1   Behringwerke Forschungslaboratorien, Marburg/Lahn
,
F. R. Seiler
1   Behringwerke Forschungslaboratorien, Marburg/Lahn
› Author Affiliations
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Publication Date:
25 June 2018 (online)

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  • LITERATUR

  • 1 Abraham E A, Mergia A, Whang J L, Tumolo A, Friedmann J, Hjerrild K A, Gospodarowicz D, Fiddes J C. Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science 1986; 233: 545-8.
    CrossrefPubMedGoogle Scholar
  • 2 Astedt B, Heimburger N. Spezifische Plasminogenaktivatorinhibitoren. Hämostaseologie 1988; 08: 233-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Auron P E, Webb A C, Rosenwasser L J, Mucci S F, Rich A, Wolff S M, Dinarello C A. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci USA 1984; 81: 7907-11.
    CrossrefPubMedGoogle Scholar
  • 4 Bakouche O, Brown D C, Lachman L B. Subcellular localization of human monocyte interleukin 1: evidence for an inactive precursor molecule and a possible mechanism for IL-1 release. J Immunol 1987; 138: 4249-55.
    PubMedGoogle Scholar
  • 5 Baumann H, Isseroff H, Latimer J J, Jahreis G P. Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells. J Biol Chem 1988; 263: 17390-6.
    PubMedGoogle Scholar
  • 6 Bensimon C, Wakasugi H, Wakasugi N, Jitsukawa S, Tursz T. A monoclonal antibody recognizing 68 to 75 kilodalton protein(s) associated with the human IL-1 receptor. J Immunol 1989; 142: 2290-8.
    PubMedGoogle Scholar
  • 7 Beutler B, Cerami A. Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature 1986; 320: 584-8.
    CrossrefPubMedGoogle Scholar
  • 8 Bevilacqua M P, Pober J S, Majeau G R, Cotran R S, Gimbrone M A. Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med 1984; 160: 618-23.
    CrossrefPubMedGoogle Scholar
  • 9 Bevilacqua M P, Pober J S, Majeau G R, Fiers W, Cotran R S, Gimbrone M A. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleu, kin 1. Proc Natl Acad Sci USA 1986; 83: 4533-7.
    CrossrefPubMedGoogle Scholar
  • 10 Breit S N, Green I. Modulation of endothelial cell synthesis of von Willebrand factor by mononuclear cell products. Haemostasis 1988; 18: 137-45.
    PubMedGoogle Scholar
  • 11 Broudy V C, Harlan J M, Adamson J W. Disparate effects of tumor necrosis factor-a/ cachectin and tumor necrosis factor-ß/lymphotoxin on hematopoietic growth factor production and neutrophil adhesion molecule expression by cultured human endothelial cells. J Immunol 1987; 138: 4298-302.
    PubMedGoogle Scholar
  • 12 Broudy V C, Kaushansky K, Harlan J M, Adamson J W. Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. J Immunol 1987; 139: 464-8.
    PubMedGoogle Scholar
  • 13 Bussolini F, Brevario F, Tetta C, Aglietta M, Mantovani A, Dejana E. Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells. J Clin Invest 1986; 77: 2027-33.
    CrossrefPubMedGoogle Scholar
  • 14 Campbell H D, Tucker W Q J, Hort Y, Martinson M E, Mayo G, Clutterbuck E J, Sauderson C J, Young J G. Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). Proc Natl Acad Sci USA 1987; 84: 6629-33.
    CrossrefPubMedGoogle Scholar
  • 15 Cannistra S A, Vellenga E, Groshek P, Rambaldi A, Griffin J D. Human granulocyte-monocyte colony stimulating factor and interleukin 3 stimulate monocyte cytotoxicity through a tumor necrosis factordependent mechanism. Blood 1988; 71: 672-6.
    PubMedGoogle Scholar
  • 16 Carlsen E, Flatmark A, Prydz H. Cytokine induced procoagulant activity in monocytes and endothelial cells. Transplant 1988; 46: 575-80.
    CrossrefPubMedGoogle Scholar
  • 17 Castell J V, Geiger T, Gross V, Andus T, Walter E, Hirano T, Kishimoto T, Heinrich P C. Plasma clearance, organ distribution and target cells of interleukin-6/hepatocytestimulating factor in rats. Eur J Biochem 1988; 177: 357-61.
    CrossrefPubMedGoogle Scholar
  • 18 Cerami A, Beutler B. The role of cachectin/ TNF in endotoxic shock and cachexia. Immunol Today 1988; 09: 28-31.
    CrossrefPubMedGoogle Scholar
  • 19 Conlon P J, Grabstein K H, Alpert A, Pricket K S, Hopp T P, Gillis S. Localization of human mononuclear cell interleukin 1. J Immunol 1987; 139: 98-102.
    PubMedGoogle Scholar
  • 20 Delvos U, Miiller-Berghaus G. Die Regulation der Blutgerinnung. Naturwissenschaften 1985; 72: 461-5.
    CrossrefPubMedGoogle Scholar
  • 21 Dinarello C A. Biology of interleukin 1. FASEB J 1988; 02: 108-15.
    CrossrefPubMedGoogle Scholar
  • 22 Dinarello C A, Clark B D, Puren A J, Savage N, Rosoff P M. The interleukin 1 receptor. Immunol Today 1989; 10: 49-51.
    CrossrefPubMedGoogle Scholar
  • 23 Dinarello C A, Cannon J G, Wolff S M, Bernheim H A, Beutler B, Cerami A, Figari I S, Palladino M A, O’Connor J V. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med 1986; 163: 1433-50.
    CrossrefPubMedGoogle Scholar
  • 24 Dower S K, Urdal D L. The interleukin 1 receptor. Immunol Today 1987; 08: 46-51.
    CrossrefPubMedGoogle Scholar
  • 25 Esmon C T. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989; 264: 4743-6.
    PubMedGoogle Scholar
  • 26 Fair D S, Marlar R A, Levin E G. Human endothelial cells synthesize protein S. Blood 1986; 67: 1168-71.
    PubMedGoogle Scholar
  • 27 Gauldie J, Richards C, Harnish D, Lausdorp P, Baumann H. Interferon ß2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA 1987; 84: 7251-5.
    CrossrefPubMedGoogle Scholar
  • 28 Goodwin R G, Lupton S, Schmierer A, Hjerrild K J, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen A E. Human interleukin 7: Molecular cloning and growth factor activity on human and mouse Blineage cells. Proc Natl Acad Sci USA 1989; 86: 302-6.
    CrossrefPubMedGoogle Scholar
  • 29 Henney C S. Interleukin 7: Effects on early events in lymphopoiesis. Immunol Today 1989; 10: 170-3.
    CrossrefPubMedGoogle Scholar
  • 30 Herrmann F, Mertelsmann R. Polypeptides controlling hematopoietic blood cell development and activation. I: In vitro results. J Clin Exp Hematol 1989; 58: 117-28.
    PubMedGoogle Scholar
  • 31 Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi K T, Kishimoto T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986; 324: 73-6.
    CrossrefPubMedGoogle Scholar
  • 32 Ikebuchi K, Ihle J N, Hirai Y, Wong G G, Clark S C, Ogawa M. Synergistic factors for stem cell proliferation: further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor. Blood 1988; 72: 2007-14.
    PubMedGoogle Scholar
  • 33 Jaye M, Howk R, Burgess W, Ricca G A, Chiu I-M, Ravera M W, O’Brien S J, Modi W S, Maciag T, Drohan W N. Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. Science 1986; 233: 541-5.
    CrossrefPubMedGoogle Scholar
  • 34 Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988; 332: 83-5.
    CrossrefPubMedGoogle Scholar
  • 35 Kirnbauer R, Köck A, Schwarz T, Urbanski A, Krutmann J, Borth W, Damm D, Shipley G, Ansel J C, Luger T A. IFN-ß2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J Immunol 1989; 142: 1922-8.
    PubMedGoogle Scholar
  • 36 Kishimoto T, Hirano T. Molecular Regulation of B-Lymphocyte Response. Ann Rev Immunol 1988; 06: 485-512.
    CrossrefPubMedGoogle Scholar
  • 37 Kurt-Jones E A, Fiers W, Pober J S. Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts. J Immunol 1987; 139: 2317-24.
    PubMedGoogle Scholar
  • 38 Kurt-Jones E A, Kiely J-M, Unanue E R. Conditions required for expression of membran IL-1 on B cells. J Immunol 1985; 135: 1548-50.
    PubMedGoogle Scholar
  • 39 Larrick J W. Native interleukin 1 inhibitors. Immunol Today 1989; 10: 61-6.
    CrossrefPubMedGoogle Scholar
  • 40 Lotz M, Jirik F, Kabouridis P, Tsoukas C, Hirano T, Kishimoto T, Carson D A. B cell stimulating factor 2/Interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med 1988; 165: 1253-8.
    PubMedGoogle Scholar
  • 41 Mann K G, Jenny R J, Krishnaswamy S. Cofactor proteins in the assembly and expression of blood clotting enzyme complexes. Ann Rev Biochem 1988; 57: 915-56.
    CrossrefPubMedGoogle Scholar
  • 42 Manson J C, Symons J A, Di Giovine F S, Poole S, Duff G W. Autoregulation of interleukin 1 production. Eur J Immunol 1989; 19: 261-5.
    CrossrefPubMedGoogle Scholar
  • 43 March C J, Mosley B, Larsen A, Cerretti D P, Braedt G, Price V, Gillis S, Henney C, Kronheim S R, Grabstein K, Conlon P J, Hopp T P, Cosman D. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 1985; 315: 641-7.
    CrossrefPubMedGoogle Scholar
  • 44 Martin M, Resch K. Interleukin 1: more than a mediator between leukocytes. TIPS 1988; 09: 171-7.
    PubMedGoogle Scholar
  • 45 Matsuda T, Hirano T, Nagasawa S, Kishimoto T. Identification of a2-macroglobulin as a carrier protein for IL-6. J Immunol 1989; 142: 148-52.
    PubMedGoogle Scholar
  • 46 Matsushima K, Tageuchi M, Kovacs E J, Young H A, Oppenheim J J. Intracellular localization of human monocyte associated interleukin 1 (IL-1) activity and release of biologically active IL-1 from monocytes by trypsin and plasmin. J Immunol 1986; 136: 2883-91.
    PubMedGoogle Scholar
  • 47 May L T, Helfegott D C, Sehgal P B. Antiß-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the ß2 interferon involved. Proc Natl Acad Sci USA 1986; 83: 8957-61.
    CrossrefPubMedGoogle Scholar
  • 48 Mimuro J, Loskutoff D J. Binding of type 1 plasminogen activator inhibitor to the extracellular matrix of cultured bovine endothelial cells. J Biol Chem 1989; 264: 5058-63.
    PubMedGoogle Scholar
  • 49 Minnich-Carruth L L, Suttles J, Mizel S B. Evidence against the existence of a membrane form of murine IL-la. J Immunol 1989; 142: 526-30.
    PubMedGoogle Scholar
  • 50 Mochizuki D Y, Eisenman J R, Conlon P J, Larsen A D, Tushinski R J. Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1. Proc Natl Acad Sci USA 1987; 84: 5267-71.
    CrossrefPubMedGoogle Scholar
  • 51 Moore K L, Esmon C T, Esmon N L. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989; 73: 159-65.
    PubMedGoogle Scholar
  • 52 Moore M A S, Warren D J. Synergy of interleukin 1 and granulocyte colony-stimulating factor: In vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc Natl Acad Sci USA 1987; 84: 7134-8.
    CrossrefPubMedGoogle Scholar
  • 53 Morrone G, Ciliberto G, Oliviereo S, Arcone R, Dente L, Content J, Cortese R. Recombinant Interleukin 6 regulates the transkriptional activation of a set of human acute phase genes. J Biol Chem 1988; 263: 12554-8.
    PubMedGoogle Scholar
  • 54 Mosley B, Dower S K, Gillis S, Cosman D. Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins la and lß. Proc Natl Acad Sci USA 1987; 94: 4572-6.
    PubMedGoogle Scholar
  • 55 Myers M J, Pullen J K, Ghildyl N, Eustis-Turf E, Schook L B. Regulation of IL-1 and TNFa expression during the differentiation of bone marrow derived macrophage. J Immunol 1989; 142: 153-60.
    PubMedGoogle Scholar
  • 56 Nawroth P P, Bank I, Handley D, Cassimeris J, Chess L, Stern D. Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1. J Exp Med 1986; 163: 1363-75.
    CrossrefPubMedGoogle Scholar
  • 57 Nawroth P P, Handley D A, Esmon C T, Stern D M. Interleukin 1 induces endothelial cell procoagulant while suppressing cell surface anticoagulant activity. Proc Natl Acad Sci USA 1986; 83: 3460-4.
    CrossrefPubMedGoogle Scholar
  • 58 Nawroth P P, Stern D M. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 1986; 163: 740-5.
    CrossrefPubMedGoogle Scholar
  • 59 Nievelstein P F E M, de Groot P G. Interactions of blood platelets with the vessel wall. Haemostasis 1988; 18: 342-59.
    PubMedGoogle Scholar
  • 60 O’Garra A, Umland S, de France T, Christiansen J. »B-cell factors« are pleiotropic. Immunol Today 1988; 09: 45-54.
    CrossrefPubMedGoogle Scholar
  • 61 Oppenheim J J, Kovacs E J, Matsushima K, Durum S K. There is more than one interleukin 1. Immunol Today 1986; 07: 45-55.
    CrossrefPubMedGoogle Scholar
  • 62 Paul N L, Ruddle N H. Lymphotoxin. Ann Rev Immunol 1988; 06: 407-38.
    CrossrefPubMedGoogle Scholar
  • 63 Pober J S, Bevilacqua M P, Mendrick D L, Lapierre L A, Fiers W, Gimbrone M A. Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol 1986; 136: 1680-7.
    PubMedGoogle Scholar
  • 64 Pober J S, Lapierre L A, Stolpen A H, Brock T A, Springer T A, Fiers W, Bevilacqua M P, Mendrick D L, Gimbrone M A. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J Immunol 1987; 138: 3319-24.
    PubMedGoogle Scholar
  • 65 Ray A, Tatter S B, May L T, Sehgal P B. Activation of the human »ß2-interferon/ hepatocyte-stimulating factor/interleukin-6« promoter by cytokines, viruses, and second messenger agonists. Proc Natl Acad Sci USA 1988; 85: 6701-5.
    CrossrefPubMedGoogle Scholar
  • 66 Rennick D, Yang G, Muller-Sieburg C, Smith C, Arai N, Takebe T, Gemmel T. Interleukin-4 (B-cell stimulatory factor-1) can enhance or antagonize the factor dependent growth of hematopoietic progenitor cells. Proc Natl Acad Sci USA 1987; 84: 6889-93.
    CrossrefPubMedGoogle Scholar
  • 67 Rimon S, Melamed R, Savion N, Scott T, Nawroth P P, Stern D M. Identification of a factor IX/IXa binding protein on the endothelial cell surface. J Biol Chem 1987; 262: 6023-31.
    PubMedGoogle Scholar
  • 68 Ruddle N H. Tumor necrosis factor and related cytokines. Immunol Today 1987; 08: 129-30.
    CrossrefPubMedGoogle Scholar
  • 69 Schleef R R, Bevilacqua M P, Sawdey M, Gimbrone M A, Loskutoff D J. Cytokine activation of vascular endothelium. J Biol Chem 1988; 263: 5797-803.
    PubMedGoogle Scholar
  • 70 Schleef R R, Loskutoff D J. Fibrinolytic system of vascular endothelial cells. Haemostasis 1988; 18: 328-41.
    PubMedGoogle Scholar
  • 71 Schleef R R, Wagner N V, Loskutoff D J. Detection of both type 1 and type 2 plasminogen activator inhibitor. J Cell Physiol 1988; 134: 269-74.
    CrossrefPubMedGoogle Scholar
  • 72 Schorer A E, Kaplan M E, Rao G H R, Moldow C F. Interleukin 1 stimulates endothelial cell tissue factor production and expression by a prostaglandin-indipendent mechanism. Thromb Haemost 1986; 56: 256-9.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 73 Sehgal P B, Grieninger G, Tosato G. (eds) Regulation of the acute phase response: a new cytokine. Annals of the New York Academy of Science. 1988: 8913.
    Google Scholar
  • 74 Seiler F R, Schwick H G. (eds) Colony stimulating factors. Behring Institute Mitteilungen. 1988. No. 83 (August)
    Google Scholar
  • 75 Shabo Y, Lotem J, Rubinstein M, Revel M, Clark S C, Wolf S F, Kamen R, Sachs L. The myeloid blood cell differentiation-inducing protein MGI-2A is Interleukin-6. Blood 1988; 72: 2070-3.
    PubMedGoogle Scholar
  • 76 Simpson R J, Moritz R L, Rubira M R, van Snick J. Murine hybridoma/plasmacytoma growth factor. Complete anino acid sequence and relation to human interleukin-6. Eur J Biochem 1988; 176: 187-97.
    PubMedGoogle Scholar
  • 77 Sims J E, March C E, Cosman D, Widmer M B, Macdonald H R, McMahan C J, Grubin D E, Wignall J M, Jackson J L, Call S M, Friend D, Alpert A R, Gillis S, Urdal D L, Dower S K. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 1988; 241: 585-9.
    CrossrefPubMedGoogle Scholar
  • 78 Sironi M, Breviario F, Proserpio P, Biooudi A, Vecchi A, van Damme J, Dejana E, Mantovani A. IL-1 stimulates IL-6 expression in endothelial cells. J Immunol 1989; 142: 549-53.
    PubMedGoogle Scholar
  • 79 Stern D M, Kaiser E, Nawroth P P. Regulation of the coagulation system by vascular endothelial cells. Haemostasis 1988; 18: 202-14.
    PubMedGoogle Scholar
  • 80 Tadmori W, Feingersh D, Clark S C, Choi T S. Human recombinant IL-3 stimulates Bcell-differentiation. J Immunol 1989; 142: 1956-62.
    PubMedGoogle Scholar
  • 81 Thieme T R, Wagner C R. The molecular weight of the endothelial cell IL-1 receptor is 78,000. Mol Immun 1989; 26: 249-53.
    CrossrefPubMedGoogle Scholar
  • 82 Tosato G, Seamon K B, Goldman N D, Sehgal P B, May L T, Washington G C, Jones K D, Pike S E. Monocyte-derived human B-cell growth factor identified as interferon-ß2 (BSF-2, IL-6). Science 1988; 239: 502-4.
    CrossrefPubMedGoogle Scholar
  • 83 Urdal D L. Persönliche Mitteilung..
    PubMedGoogle Scholar
  • 84 Urdal D L, Call S M, Jackson J L, Dower S K. Affinity purification and chemical analysis of the interleukin-1 receptor. J Biol Chem 1988; 263: 2870-7.
    PubMedGoogle Scholar
  • 85 van Damme J, Opdenakker G, Simpson R J, Rubira M R, Cayphas S, Vink A, Billiau A, van Snick J. Identification of the human 26 kD protein, Interferon ß2 (IFN-ß2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med 1987; 165: 914-9.
    CrossrefPubMedGoogle Scholar
  • 86 Wang A M, Creasey A A, Ladner M B, Lin L S, Strickler J, van Arsdell J N, Yamamoto R, Mark D F. Molecular Cloning of the Complementary DNA for human tumor necrosis factor. Science 1985; 228: 149-54.
    CrossrefPubMedGoogle Scholar
  • 87 Wickner W T, Lodish H F. Multiple mechanisms of protein insertion into and across membranes. Science 1985; 230: 400-7.
    CrossrefPubMedGoogle Scholar
  • 88 Wong G G, Clark S C. Multiple actions of interleukin 6 within a cytokine network. Immunol Today 1988; 09: 137-9.
    CrossrefPubMedGoogle Scholar
  • 89 Yasukawa K, Hirano T, Watanabe Y, Muratani K, Matsuda T, Nakai S, Kishimoto T. Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J 1987; 06: 2939-45.
    PubMedGoogle Scholar
  • 90 Ye R D, Wun T-C, Sadler J E. cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta. J Biol Chem 1987; 262: 3718-25.
    PubMedGoogle Scholar
  • 91 Ye R D, Wun T-C, Sadler J E. Mammalian protein secretion without signal peptide removal. J Biol Chem 1988; 268: 4869-75.
    PubMedGoogle Scholar
  • 92 Yokota T, Takeshi O, Mosmann T, Bachereau J, De France T, Blanchard D, De Vries J E, Lee E, Arai E. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc Natl Acad Sci USA 1986; 83: 5894-8.
    CrossrefPubMedGoogle Scholar
  • 93 Zhou Y-Q, Stanley E R, Clard S C, Hatzfeld J A, Levesque J-P, Federici C, Watt S M, Hatzfeld A. Interleukin-3 and Interleukin-la allow earlier bone marrow progenitors to respond to human colony-stimulating factor 1. Blood 1988; 72: 1870-4.
    PubMedGoogle Scholar