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Thromb Haemost 1970; 23(02): 276-285
DOI: 10.1055/s-0038-1654140
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Platelets in Rheumatoid Arthritis

J Pazdur
1   Hematological Department, Institute of Rheumatology, Warsaw
,
Maria Kopeć
1   Hematological Department, Institute of Rheumatology, Warsaw
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

Platelet counts and adhesiveness in vivo were examined in 140 patients with rheumatoid arthritis and in 30 healthy subjects. Increased platelet counts were found in 50% of cases and impaired adhesiveness in vivo in 40%. Thrombocyte counts showed high positive correlation with leukocytosis but none with adhesiveness in vivo and degree of anemia. Ivy bleeding time was prolonged in 15 among 30 examined r.a. cases. Adhesion of normal platelets to purified collagen prepared from tendons of r.a. patients was found to be unimpaired. Aggregation of platelets with connective tissue extracts was delayed in r.a. PRP as compared with normal PRP. Extracts of r.a. synovia was less effective as aggregating agent than extracts of control synovia. It was found that a single dose of aspirin (2 g) does not influence platelet adhesiveness in vivo in healthy persons. On the basis of the presented results and literature data it is suggested that overproduction of platelets is a probable cause of thrombocytosis in r. a. while impairment of in vivo adhesiveness may be due to intrinsic defect of platelet and/or to presence of some inhibitory substances in blood and tissues.

 

  • References

  • 1 Borchgrevinck Ch. F. A method for measuring platelet adhesiveness in vivo. Acta med. scand 168: 157 1960;
    PubMedGoogle Scholar
  • 2 Bounameaux Y. L’accolment des plaquettes aux fibers sous endotheliales. Thrombos. Diathes. haemorrh. (Stuttg.) 6: 504 1961;
    PubMedGoogle Scholar
  • 3 Brown Patricia C, Consden R, Glynn L. E. Observation on the shrink temperature of collagen and its variations with age and disease. Ann. rheum. Dis 17: 196 1958;
    CrossrefPubMedGoogle Scholar
  • 4 Einbinder J, Schubert H. Binding of mucopolisaccharides and dyes by collagen. J. biol. Chem 188: 355 1950;
    PubMedGoogle Scholar
  • 5 Evans G, Nishizawa E. E, Packham M. A, Mustard J. F. Effect of acetylosalicylic acid (aspirin) on platelet function. Blood 30: 550 1967;
    PubMedGoogle Scholar
  • 6 Feissly R, Lüdin H. Microscopie par Contraste de Phase. Rev. Hémat 4: 481 1949;
    PubMedGoogle Scholar
  • 7 Gast L. F. Influence of aspirin on haemostatic parameters. Ann. rheum. Dis 23: 500 1964;
    CrossrefPubMedGoogle Scholar
  • 8 Glynn M. F, Murphy E. A, Mustard J. F. Platelets and thrombosis. Ann. intern. Med 64: 715 1966;
    CrossrefPubMedGoogle Scholar
  • 9 Gross S, Keefer V, Newman A. The platelets in iron-deficiency anaemia. I. The response to oral and parenteral iron. Pediatrics 34: 315 1966;
    PubMedGoogle Scholar
  • 10 Hirsh J, Dacie J. Persistent post-splenectomy thrombocytosis and thromboembolism: a consequence of continuing anaemia. Brit. J. Haemat 12: 44 1966;
    CrossrefPubMedGoogle Scholar
  • 11 Hugues J. Accolement des placjuettes aux structures conjonctives périvasculaires. Thrombos. Diathes. haemorrh. (Stuttg.) 8: 241 1962;
    PubMedGoogle Scholar
  • 12 Hunder G, Vaughan J, Jacox R. The rheumatoid factor activity of dextran eluates of erythrocytes and platelets. Arth. Rheum 6: 191 1963;
    CrossrefPubMedGoogle Scholar
  • 13 Ivy A. G, Shapiro P. F, Melnick P. The bleeding tendency in jaundice. Surg. Gynec. Obst 60: 781 1935;
    PubMedGoogle Scholar
  • 14 Kerby G. P, Taylor S. M. The acid mucopolisaccharide and 5-hydroxytryptamine content of human thrombocytes in rheumatoid arthritis and nonarthritic individuals. J. clin. Invest 38: 1059 1959;
    CrossrefPubMedGoogle Scholar
  • 15 Kunkel H. Studies on the isolation and characterisation of the “rheumatoid factor”. J. clin. Invest 55: 424 1959;
    PubMedGoogle Scholar
  • 16 Marchasin S, Wallenstein R, Aggeler P. M. Variations of the platelet count in disease. Calif. Med 101: 95 1964;
    PubMedGoogle Scholar
  • 17 McClure P, Ingram G. I, Glass Ursula, Matchett Myrtle. Platelet function tests in thrombo-cythaemia and thrombocytosis. Brit. J. Haemat 12: 478 1966;
    CrossrefPubMedGoogle Scholar
  • 18 McKay D. Diseases of hypersensitivity. Disseminated intravascular coagulation. Arch, intern. Med 116: 83 1965;
    CrossrefPubMedGoogle Scholar
  • 19 Mustard J. F, Murphy E. A, Robinson G, Rotaseli H. C, Ozge A. H, Crookston J. Blood platelet survival. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl 13: 245 1963;
    PubMedGoogle Scholar
  • 20 O’Brien J. R. Effects of salicylates on human platelets. Lancet I: 779 (1968).
    PubMedGoogle Scholar
  • 21 Packham M. A, Warrior E. S, Glynn M. F, Senyi A. S, Mustard J. F. Alteration of the response of platelets to surface stimuli by pyrazole compounds. J. exp. Med 126: 171 1967;
    CrossrefPubMedGoogle Scholar
  • 22 Pachter M, Johnson S, Basinski D. The effect of macroglobulins and their dissociation units on release of platelet factor 3. Thrombos. Diathes. haemorrh. (Stuttg.) 3: 501 1959;
    PubMedGoogle Scholar
  • 23 Pazdur J. Der Einfluß der bei Polyarthritis angewandten Medikamente auf die Funktion der Thrombozyten. Folia hemat. (In press.)
    PubMedGoogle Scholar
  • 24 Quick A. J. Salicylates and bleeding: the aspirin tolerance test. Amer. J. med. Sci 252: 265 1966;
    CrossrefPubMedGoogle Scholar
  • 25 Ropes M. W, Bennett G. A, Cobb S, Jacox R. F, Iessar R. A. 1958 revision of diagnostic criteria for rheumatoid arthritis. Bull, rheum. Dis 9: 175 1958;
    PubMedGoogle Scholar
  • 26 Sahud M. A, Aggeler P. M. Platelet dysfunction – differentiation of a primary type from that produced by aspirin. New. Engl. J. Med 280: 453 1969;
    CrossrefPubMedGoogle Scholar
  • 27 Schloesser L, Kipp M, Wenzel F. Thrombocytosis in iron-deficiency anaemia. J. Lab. clin. Med 66: 107 1965;
    PubMedGoogle Scholar
  • 28 Schmid F, Cooper N, Ziff M, McEwen C. Arteritis in rheumatoid arthritis. Amer. J. Med 50: 56 1961;
    PubMedGoogle Scholar
  • 29 Sokolojf L, Wilens S, Bzinim J. Arteritis of striated muscle in rheumatoid arthritis. Amer. J. Path 27: 157 1951;
    PubMedGoogle Scholar
  • 30 Sorensen E. Myelomatosis. Acta med. scand 178: 687 1965;
    PubMedGoogle Scholar
  • 31 Steven F. Evidence for a deficiency in intermolecular cross-linking in collagen fibrills isolated from rheumatoid joints. Ann. rheum. Dis 25: 563 1966;
    CrossrefPubMedGoogle Scholar
  • 32 Takeda Y. Studies of the metabolism and distribution of fibrinogen in patients with rheumatoid arthritis. J. Lab. clin. Med 69: 624 1967;
    PubMedGoogle Scholar
  • 33 Vigliano E, Horowitz H. I. Bleeding syndrome in a patient with IgA myeloma. Interaction of protein and connective tissue. Blood 29: 823 1967;
    PubMedGoogle Scholar
  • 34 Weiss H. J, Aledort L. M, Kochwa S. The effect of salicylates on the hemostatic properties of platelets in man. J. clin. Invest 47: 2169 1968;
    CrossrefPubMedGoogle Scholar
  • 35 Woessner J. F. The determination of OH-proline in tissue and protein samples containing “small proportions” of this amino acid.Arch. Biochem 93: 440 1961;
    PubMedGoogle Scholar
  • 36 Zucker M. B, Borelli J. Platelet clumping produced by connective tissue suspension and by collagen. Proc. Soc. exp. Biol. (N. Y.) 109: 779 1962;
    CrossrefPubMedGoogle Scholar
  • 37 Zucker M. B, Peterson J. Inhibition of adenosine diphosphate – induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion. Proc. Soc. exp. Biol. (N. Y.) 127: 547 1968;
    CrossrefPubMedGoogle Scholar