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Thromb Haemost 1969; 22(01): 028-031
DOI: 10.1055/s-0038-1651325
Originalarbeiten-Original Articles-Travaux Originaux
Schattauer GmbH

Differences in the Effect of Antithrombin on Thrombin Clotting and Thrombin Esterase Activity[*]

H Gans
1   Department of Surgery, the New York Hospital-Cornell University Medical College, New York, N. Y. 10021
,
A Boulton
1   Department of Surgery, the New York Hospital-Cornell University Medical College, New York, N. Y. 10021
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Publikationsdatum:
10. Juni 2018 (online)

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Summary

Following the addition of thrombin to serum, thrombin clotting activity rapidly disappears. During the first half hour thrombin esterase activity also declines. Subsequently, the thrombin esterase activity remains stable for a long time.

Heparin which, under these circumstances profoundly alters the thrombin clotting-activity, affects the thrombin esterase activity only slightly. Hence serum induced inhibition of thrombin esterase activity is not significantly altered by heparin.

The possible relationship of these findings to the spontaneous resolution of thrombo-emboli is discussed.

* Supported by Grant No. HE 05341 and HE 12324 from the U.S. Public Health Service, National Institutes of Health, National Heart Institute and a N.I.H. Research Career Program Award.


 

  • References

  • 1 Landaburu R. H, Seegers W. H. The Acetylation of Prothrombin. Can. J. Biochem. 38: 613 1960;
    PubMedGoogle Scholar
  • 2 Lanchantin G. F. et al.: Dissociation of Esterolytic and Clotting Activities of Thrombin by Trypsin-Binding Microglobulin. Proc. Soc. exp. Biol. (N. Y.) 121: 444 1966;
    CrossrefPubMedGoogle Scholar
  • 3 Landaburu R. H, Seegers W. H. The Acetylation of Thrombin. Canad. J. Biochem. 37: 1361 1959;
    PubMedGoogle Scholar
  • 4 Engel A, Alexander B, Rechet L. Activation of Trypsinogen and Plasminogen by Thrombin Preparations. Biochemistry 5: 1543 1966;
    CrossrefPubMedGoogle Scholar
  • 5 Seegers W. H, Landaburu R. H, Johnson J. F. Thrombin-E as a Fibrinolytic Enzyme. Science 131: 726 1960;
    CrossrefPubMedGoogle Scholar
  • 6 Seegers W. H, Nieft M, Loomis E. G. Note on the Adsorption of Thrombin on Fibrin. Science 101: 520 1945;
    CrossrefPubMedGoogle Scholar
  • 7 Gans H, Tan B. H. Alpha1-Antitrypsin, An Inhibitor for Thrombin and Plasmin. Clin, chim. Acta 17: 111 1967;
    CrossrefPubMedGoogle Scholar
  • 8 Ganrot P. O. Inhibition of Plasmin Activity by Alpha2-Macroglobulin. Clin. chim. Acta 16: 328 1967;
    CrossrefPubMedGoogle Scholar
  • 9 Gans H, Subramanian V, Tan B. H. Selective Phagocytosis: A New Concept in Protein Catabolism. Science 159: 107 1968;
    CrossrefPubMedGoogle Scholar
  • 10 Hummel B. C. W. A Modified Spectrophotometry Determination of Chymotrypsin, Trypsin and Thrombin. Canad. J. Biochem. 37: 1393 1959;
    PubMedGoogle Scholar
  • 11 Supported by PHS Grants (HE 05341 and HE 12324).
    PubMed