Download PDF
Thromb Haemost 1968; 19(01/02): 198-203
DOI: 10.1055/s-0038-1651196
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Sustained Lymphatic Delivery of Fibrinogen after Induced Afibrinogenemia[*]

Margaret C. Young   **
1   Department of Physiology, University of Texas Medical Branch, Galveston, Texas 77550
,
S. N Kolmen
1   Department of Physiology, University of Texas Medical Branch, Galveston, Texas 77550
› Author Affiliations
Further Information

Publication History

Publication Date:
27 June 2018 (online)

    Permissions and Reprints

Summary

Lymphatic fibrinogen levels were maintained for a long period in the absence of plasma fibrinogen. Although a portion of the additional fibrinogen required may have been the result of de novo synthesis, an additional source, that of previously sequestered fibrinogen in storage sites, must have been present.

The amount of fibrinogenolysis induced, although complete in the plasma compartment of dogs, was not as effective in the lymphatic compartment. One resultant of fibrinogenolytic induction in vivo was retardation of fibrin polymerization in incubated lymph samples.

* This investigation was supported, in part, by USPHS Grant AM-08449 from Institute of Arthritis and Metabolic Diseases.


** James W. McLaughlin Predoctoral Fellow in Infection and Immunity, University of Texas Medical Branch.


 

  • References

  • 1 Atencio A.C, Bailey H.R, Reeves E.B. Studies on the metabolism and distribution of fibrinogen in young and older rabbits, I. Methods and models. J. Lab. clin. Med. 1965; 66: 1-19
    PubMedGoogle Scholar
  • 2 Adelson E. Normal metabolism. Fed. Proc. 1965; 24: 810-815
    PubMedGoogle Scholar
  • 3 Kolmen S.N, Vita A.E. Passage of fibrinogen to circulation via lymphatics. Amer. J. Physiol. 1962; 202: 671-674
    PubMedGoogle Scholar
  • 4 Kolmen S.N, Daily L.J, Traber D.L. Autonomic involvement in the lymphatic delivery of fibrinogen. Amer. J. Physiol. 1965; 209: 1123-1127
    PubMedGoogle Scholar
  • 5 Traber D.L, Kolmen S.N. Adsorption of fibrinogen onto erythrocytic surfaces. Tex. Rep. Biol. Med. 1965; 23: 782-792
    PubMedGoogle Scholar
  • 6 Traber D.L, Kolmen S.N. Influence of pH, pCO2 and pO2 on erythrocytic adsorption of fibrinogen. Proc. Soc. exp. Biol. (N. Y.) 1966; 122: 385-388
    CrossrefPubMedGoogle Scholar
  • 7 Traber D.L, Haynes J, Daily L.J, Kolmen S.N. Coagulation defects as a result of chronic lymphatic diversion. Tex. Rep. Biol. Med. 1963; 21: 587-600
    PubMedGoogle Scholar
  • 8 Foster J.B.T, DeNatale A, Dotti L.B. Determination of plasma fibrinogen by means of centrifugation after heating. Amer. J. clin. Path. 1959; 31: 42-45
    PubMedGoogle Scholar
  • 9 Kolmen S.N, Quest M.M, Celander D.R. Evidence for the adsorption upon erythrocytes of urokinase and other components of the fibrinolytic system. Arch. Biochem. 1959; 85: 334-344
    CrossrefPubMedGoogle Scholar
  • 10 Forman W.B, Barnhart M.I. Cellular site for fibrinogen synthesis. J. Amer. med. Ass. 1964; 187: 128-132
    PubMedGoogle Scholar
  • 11 Ross J.K. A review of the surgery of the thoracic duct. Thorax 1961; 16: 12-21
    CrossrefPubMedGoogle Scholar
  • 12 Triantaphyllopoulos D.C. Enzymatic effects of fibrinolysin. Fed. Proc. 1965; 24: 800-803
    PubMedGoogle Scholar
  • 13 Fletcher A.P, Alkjaersig N, Sherry S. Significance of fibrinogen proteolysis and circulating fibrinogen breakdown products. J. clin. Invest. 1962; 41: 896-916
    CrossrefPubMedGoogle Scholar
  • 14 Holemans R, Johnston J.G, McConnell D, Woldow I. Increase in plasminogen activator content of arterial walls in pregnant dogs. Fed. Proc. 1966; 25: 323
    PubMedGoogle Scholar