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Thromb Haemost 1981; 45(01): 018-023
DOI: 10.1055/s-0038-1650121
Original Article
Schattauer GmbH Stuttgart

The Effect of Local Anaesthetics and Antiarrhythmic Agents on the Responses of Rabbit Platelets to ADP and Thrombin

Esther R Anderson
The Department of Pharmacology, Faculty of Medicine, The University of British Columbia, Vancouver, Canada
,
J G Foulks
The Department of Pharmacology, Faculty of Medicine, The University of British Columbia, Vancouver, Canada
,
D V Godin
The Department of Pharmacology, Faculty of Medicine, The University of British Columbia, Vancouver, Canada
› Author Affiliations
Further Information

Publication History

Received 23 May 1980

Accepted 28 October 1980

Publication Date:
04 July 2018 (online)

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Summary

Local anaesthetics and antiarrhythmic agents produced changes in responses of rabbit platelets to ADP and thrombin that varied with the agent and its concentration. In high concentrations all local anaesthetics decreased aggregation rates. At lower concentrations several local anaesthetics increased aggregation rates. Depending on the agonist and local anaesthetic, increases were produced at all or only at low or high agonist concentrations. Local anaesthetics failed to influence shape change except at concentrations much greater than those which inhibited aggregation. Inhibition of aggregation by procaine was potentiated by small organic anions suggesting effects at different sites on the platelet membrane. The inhibitory effect of local anaesthetics was decreased by increasing Ca. Kinetic analysis indicated different mechanisms for this Ca effect, i. e., predominantly competitive for procaine or lidocaine and predominantly non-competitive for tetracaine or ethyl lidocaine. Local anaesthetics may affect aggregation by modifying the participation of Ca in this process.

Keywords

Platelets - Aggregation - Local anaesthetics - Antiarrhythmic agents
 

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