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Thromb Haemost 1980; 43(03): 203-207
DOI: 10.1055/s-0038-1650052
Original Article
Schattauer GmbH Stuttgart

Increased Bleeding during Liver Resection in Ethanol-Intoxicated Rats

Stig Bengmark
The Department of Surgery, University of Lund, Lund, Sweden and the Department of Anesthesiology, University of Lund, Malmö, Sweden
,
Göran Göransson
The Department of Surgery, University of Lund, Lund, Sweden and the Department of Anesthesiology, University of Lund, Malmö, Sweden
,
Jan Idvall
The Department of Surgery, University of Lund, Lund, Sweden and the Department of Anesthesiology, University of Lund, Malmö, Sweden
,
Evita Zoucas
The Department of Surgery, University of Lund, Lund, Sweden and the Department of Anesthesiology, University of Lund, Malmö, Sweden
› Author Affiliations
Further Information

Publication History

Received 24 December 1979

Accepted 02 June 1980

Publication Date:
13 July 2018 (online)

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Summary

The effect of ethanol intoxication on hemostasis after liver resection was studied in the rat. Plasma levels of ethanol were within the range of those found in ethanol intoxication in man. Bleeding time and blood loss were significantly increased, whereas hemoglobin and hematocrit values were decreased after resection in intoxicated animals compared to controls. APT-times and platelet counts did not differ significantly between the two groups of rats. ADP- and collagen-induced platelet aggregation was slightly inhibited one hour after ethanol administration in non-operated animals. A decrease in pH, such as observed in intoxicated animals, did not affect hemostasis. Distribution of cardiac output was significantly altered after ethanol intoxication. Renal blood flow was increased by 54%, blood flow in the hepatic artery by 40% and in the portal vein by 47%.

Keywords

Ethanol-intoxication - Bleeding time - Blood loss - Platelet aggregation
 

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