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Thromb Haemost 1993; 70(05): 848-851
DOI: 10.1055/s-0038-1649681
Fibrinolysis
Schattauer GmbH Stuttgart

A Parent-Twin Study of Plasma Levels of Histidine-Rich Glycoprotein (HRG)

D I Boomsma
1   The Department of Psychonomics, Vrije Universiteit, Amsterdam, The Netherlands
,
B C Hennis
2   The IVVO/TNO, Gaubius Laboratory, Leiden, The Netherlands
,
A G M van Wees
2   The IVVO/TNO, Gaubius Laboratory, Leiden, The Netherlands
,
R R Frants
3   The Department of Human Genetics, Leiden University, Leiden, The Netherlands
,
C Kluft
2   The IVVO/TNO, Gaubius Laboratory, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 13 October 1992

Accepted after revision 21 June 1993

Publication Date:
05 July 2018 (online)

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Summary

Histidine-rich glycoprotein (HRG) is a non-enzymatic glycoprotein that acts as a modulator of several plasma proteins involved in coagulation and fibrinolysis. The contributions of genetic and environmental influences to inter-individual variation in plasma levels of HRG were studied in 160 Dutch families consisting of adolescent twin pairs and their parents. Results showed that 69% of the variance in plasma HRG concentrations could be accounted for by genetic factors. Heritability was the same in males and females and in parents and their offspring. There was no association between HRG levels of husband and wife and no evidence was found for the influence of shared family environment on the resemblance between relatives.

 

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