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Thromb Haemost 1977; 37(03): 523-526
DOI: 10.1055/s-0038-1649261
Original Article
Schattauer GmbH

Factor VIII Inhibitor Associated with Chlorpromazine-Induced Hepatic Injury

Richard L Glazier
1   Department of Medicine, University of Wisconsin, Center for Health Sciences, Madison, Wisconsin,, 53706 U.S.A.
,
Edward B Crowell Jr.
1   Department of Medicine, University of Wisconsin, Center for Health Sciences, Madison, Wisconsin,, 53706 U.S.A.
› Author Affiliations
Further Information

Publication History

Received 14 October 1976

Accepted 08 January 1977

Publication Date:
03 July 2018 (online)

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Summary

A 90-year-old man was given chlorpromazine for sedation and 2 weeks later developed cholestatic jaundice and subsequently a factor VIII inhibitor. His death 4 weeks after institution of chlorpromazine, from massive bleeding, coupled with the autopsy finding of intrahepatic cholestatic jaundice, suggests that both adverse reactions were due to the drug.

 

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