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Thromb Haemost 1977; 37(03): 484-508
DOI: 10.1055/s-0038-1649259
Original Article
Schattauer GmbH

Use of 125I-Fibrinogen Kinetic Data to Detect Disseminated Intravascular Coagulation and Deposition of Fibrin in Patients with Metastatic Cancer

Elean B Robson
1   State University of New York at Buffalo, N. Y. 14215, U. S. A.
,
Gail F Murawski
1   State University of New York at Buffalo, N. Y. 14215, U. S. A.
,
Richard E Bettigole
1   State University of New York at Buffalo, N. Y. 14215, U. S. A.
› Author Affiliations
Further Information

Publication History

Received 20 September 1976

Accepted 25 March 1977

Publication Date:
03 July 2018 (online)

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Summary

A technique using computerized data handling for following the fate of 125I-fibrinogen through various physiological compartments is presented. Its use in detecting fibrin build up in patients with metastatic tumors and cancer-caused DIC is explained. An increase in j3u (fractional catabolic rate as seen in the urine data) throughout the course of a study was found to be an important indicator of extravascular fibrin build up.

 

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