Thromb Haemost 1974; 32(02/03): 549-553
DOI: 10.1055/s-0038-1647723
Original Article
Schattauer GmbH

Evidence that Human Platelet Aggregating Activity in Porcine Plasma is a Property of von Willebrand Factor

G de Gaetano
1   Laboratory for Haemostasis and Thrombosis Research, Istituto di Ricerche Farmacologiche “Mario Negri” Milano, Italy, and Laboratory of Blood Coagulation, Medical Research Department, University of Leuven, Belgium
,
M. B Donati
1   Laboratory for Haemostasis and Thrombosis Research, Istituto di Ricerche Farmacologiche “Mario Negri” Milano, Italy, and Laboratory of Blood Coagulation, Medical Research Department, University of Leuven, Belgium
,
J Vermylen
1   Laboratory for Haemostasis and Thrombosis Research, Istituto di Ricerche Farmacologiche “Mario Negri” Milano, Italy, and Laboratory of Blood Coagulation, Medical Research Department, University of Leuven, Belgium
› Author Affiliations
Further Information

Publication History

Received 31 May 1974

Accepted 20 June 1974

Publication Date:
30 June 2018 (online)

Summary

Plasma from normal pigs, but not from a pig affected with von Willebrand’s disease, aggregates human platelets. The aggregating activity therefore seems to be a property of porcine von Willebrand factor.

 
  • References

  • 1 Born G. V. R. 1970; Observations on the change in shape of blood platelets brought about by adenosine diphosphate. Journal of Physiology 209: 487.
  • 2 Bowie E. J. W, Owen Jr. C. A, Zollman P. E, Thompson Jr. J. H, Fass D. N. 1973; Tests of hemostasis in swine: normal values and values in pigs affected with von Willebrand’s disease. American Journal of Yeterinary Research 34: 1405.
  • 3 De Gaetano G, Veemylen J, Verstraete M. 1970; Platelet aggregation by a specific human immunoglobulin preparation. Thrombosis et Diathesis Haemorrhagica 24: 419.
  • 4 Donati M. B, De Gaetano G, Yermylen J. 1973; Evidence that bovine factor VIII, not bovine fibrinogen, aggregates human platelets. Thrombosis Research 02: 97.
  • 5 Forbes C. D, Prentice C. R. M. 1973; Aggregation of human platelets by purified porcine and bovine antihaemophilic factor. Nature, New Biology 241: 149.
  • 6 Griggs T. R, Cooper H. A, Webster W. P, Wagner R. H, Brinkhous K. M. 1973; Plasma aggregating factor (bovine) for human platelets: a marker for study of antihemophilic and von Willebrand factors. Proceedings of the National Academy of Sciences, U.S.A 70: 2814.
  • 7 Michal F. 1971; Light scattering and platelet aggregation. Acta Medica Scandinavica, supplementum 525: 45.
  • 8 Owen Jr. C. A, Bowie E. J. W, Zollman P. E, Fass D. N, Gordon H. 1974; Carrier of porcine von Willebrand’s disease. American Journal of Veterinary Research 35: 245.
  • 9 Vermylen C, De Vreker R. A, Verstraete M. 1963; A rapid enzymatic method for assay of fibrinogen: fibrin polymerization time (FPT) Test. Clinica Chimica Acta 08: 418.
  • 10 Vermylen C, Verstraete M. 1968; A simple method for assay of factor VIII, using 20 microlitres of capillary blood. British Journal of Haematology 14: 241.