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Thromb Haemost 1989; 61(03): 522-525
DOI: 10.1055/s-0038-1646627
Original Article
Schattauer GmbH Stuttgart

Plasma D Dimer: A Useful Marker of Fibrin Breakdown in Renal Failure

M P Gordge
The Dept. of Renal Medicine, Institute of Urology, St. Philips Hospital, London, UK
,
R W Faint
The Dept. of Renal Medicine, Institute of Urology, St. Philips Hospital, London, UK
,
P B Rylance
The Dept. of Renal Medicine, Institute of Urology, St. Philips Hospital, London, UK
,
H Ireland
1   The Dept. of Haematology, Charing Cross and Westminster Medical School, London, UK
,
D A Lane
1   The Dept. of Haematology, Charing Cross and Westminster Medical School, London, UK
,
G H Neild
The Dept. of Renal Medicine, Institute of Urology, St. Philips Hospital, London, UK
› Author Affiliations
Further Information

Publication History

Received 18 October 1988

Accepted after revision 10 March 1989

Publication Date:
24 July 2018 (online)

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Summary

D dimer and other large fragments produced during the breakdown of crosslinked fibrin may be measured by enzyme immunoassay using monoclonal antibodies. In 91 patients with renal disease and varying degrees of renal dysfunction, plasma D dimer showed no correlation with renal function, whereas FgE antigen, a fibrinogen derivative which is known to be cleared in part by the kidney, showed a significant negative correlation with creatinine clearance. Plasma concentrations of D dimer were, however, increased in patients with chronic renal failure (244 ± 3l ng/ml) (mean ± SEM) and diabetic nephropathy (308 ± 74 ng/ml), when compared with healthy controls (96 ± 13 ng/ml), and grossly elevated in patients with acute renal failure (2,451 ± 1,007 ng/ml). The results indicate an increase in fibrin formation and lysis, and not simply reduced elimination of D dimer by the kidneys, and are further evidence of activated coagulation in renal disease. D dimer appears to be a useful marker of fibrin breakdown in renal failure.

Keywords

Renal failure - D dimer - Fibrin - Fibrinolysis
 

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