Effect of 4-Hydroxy-2,3-trans-nonenal on Platelet Function

Michael L Selley; Julie A McGuiness; Lynn A Jenkin; Mark R Bartlett; Neville G Ardlie

doi:10.1055/s-0038-1642743

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1988; 59(02): 143-146
DOI: 10.1055/s-0038-1642743

Original Articles

Schattauer GmbH Stuttgart

Effect of 4-Hydroxy-2,3-trans-nonenal on Platelet Function

Michael L Selley

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

,

Julie A McGuiness

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

,

Lynn A Jenkin

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

,

Mark R Bartlett

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

,

Neville G Ardlie

The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

› Institutsangaben

Abstract

als PDF herunterladen

Summary

4-Hydroxy-2,3-trans-nonenal (HNE), an aldehyde end-product of lipid peroxidation, potentiated aggregation and increased thromboxane A₂ formation in platelets challenged with ADP, thrombin or the ionophore A23187. These effects were observed at HNE concentrations in the range 10-100 μM. Platelet responses to collagen, epinephrine and arachidonic acid were not affected by PINE. Concentrations of HNE in excess of 100 pM inhibited platelet activation. HNE increased the release of ³H-arachidonic acid from prelabelled platelet phospholipids in response to thrombin or ADR It is proposed that HNE may play an important role in controlling platelet function by regulating the activity of phospholipase A₂.

Keywords

Platelet - 4-Hydroxy-2,3-trans-nonenal-lipid peroxidation

PDF (285 kb)

Referenzen

References
1 Zucker MB, Nachmias VT. Platelet activation. Atherosclerosis 1985; 5: 2-18
2 Ross R. Atherosclerosis: a problem of the biology of arterial cell walls and their interactions with blood components. Atherosclerosis 1981; 1: 293-311
3 Hamberg M, Svensson J, Samuelsson B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 1975; 72: 2994-2998
4 Van den Bosch H. Intracellular phospholipases. Biochim Biophys Acta 1980; 604: 191-246
5 Slater TF. Free-radical mechanisms in tissue injury. Biochem J 1984; 222: 1-15
6 Benedetti A, Comporti M, Esterbauer H. Identification of 4-hydroxy-nonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids. Biochim Biophys Acta 1980; 620: 281-296
7 Dianzani MU. Biochemical effects of saturated and unsaturated aldehydes. In: Free Radicals, Lipid Peroxidation and Cancer McBrien DC H, Slater JF. (eds.) pp 129-158 Academic Press; London: 1982
8 Curzio M, Torrielli MV, Giroud JP, Esterbauer H, Dianzani MU. Neutrophil chemotactic responses to aldehydes. Res Commun Chem Pathol Pharmacol 1982; 36: 463-476
9 Jurgens G, Lang J, Esterbauer H. Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal. Biochim Biophys Acta 1986; 875: 103-114
10 Brambilla G, Sciaba L, Faggin P, Maura A, Marinari UM, Ferro M, Esterbauer H. Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes. Mutat Res 1986; 171: 169-176
11 Esterbauer H. Aldehydic products of lipid peroxidation. In: Free Radicals, Lipid Peroxidation and Cancer. McBrien DC H, Slater TF. (eds.) Academic Press; London: 1982. pp 101-128
12 Esterbauer H, Ertl A, Scholz N. The reaction of cysteine with α,β-unsaturated aldehydes. Tetrahedron 1976; 32: 285-289
13 Cadenas E, Muller A, Brigelius R, Esterbauer H, Sies H. Effects of 4-hydroxynonenal on isolated hepatocytes. Studies on chemiluminescence response, alkane production and glutathione status Biochem J 1983; 214: 479-487
14 Esterbauer H, Benedetti A, Lang J, Fulceri R, Faiiler G, Comporti M. Studies on the mechanism of formation of 4-hydroxynonenal during microsomal lipid peroxidation. Biochim Biophys Acta 1986; 876: 154-166
15 Esterbauer H, Cheeseman KH, Dianzani MU, Poli G, Slater TF. Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe²⁺ in rat liver microsomes. Biochem J 1982; 208: 129-140
16 Cazenave JP, Packham MA, Mustard JF. Adherence of platelets to a collagen-coated surface: development of a quantitative model, j Lab Clin Med. 1973; 82: 978-990
17 Cameron HA, Archie NG. The facilitating effects of adrenaline on platelet aggregation. Prostaglandins Leukotrienes Med 1982; 9: 117-128
18 Esterbauer H, Weger W. Über die Wirkungen von Aldehyden auf gesunde und maligne Zellen, 3. mitt: Synthese von homologen 4- hydroxy-2-alkenalen. II. Monatsh Chem 1967; 98: 1994-2000
19 Kannagi R, Koizumi K. Effect of different physical states of phospholipid substrates on partially purified platelet phospholipase A₂activity. Biochim Biophys Acta 1979; 556: 423-433
20 Mauco G, Chap H, Douste-Blazy L. Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol. FEBS Lett 1979; 100: 367-370
21 Vladimirov Yu A, Olenev VI, Suslova TB. Cheremisina Z R Lipid peroxidation in mitochondrial membrane. Adv Lipid Res 1980; 17: 173-249
22 Esterbauer H, Roller E, Slee RG, Koster JF. Possible involvement of the lipid-peroxidation product 4-hydroxynonenal in the formation of fluorescent chromolipids. Biochem J 1986; 239: 405-409
23 Douglas CE, Chan AC, Choy C. Vitamin E inhibits platelet phospholipase A₂ . Biochim Biophys Acta 1986; 876: 639-645
24 Yasuda M, Fujita T. Effect of lipid peroxidation on phospholipase A₂activity of rat liver mitochondria. Jpn J Pharmacol 1977; 27: 429-435
25 Fujimoto Y, Tanioka H, Keshi I, Fujita T. The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney medulla slices. Biochem J 1983; 212: 167-171
26 Sevanian A, Muakkassah-Kelly SF, Montestruque S. The influence of phospholipase A₂ and glutathione peroxidase on the elimination of membrane lipid peroxides. Arch Biochem Biophys 1983; 223: 441-452
27 Tan KH, Meyer DJ, Belin J, Ketterer B. Inhibition of microsomal lipid peroxidation by glutathione and glutathione transferases B and AA. Role of endogenous phospholipase A? Biochem J 1984; 220: 243-252
28 Sevanian A, Kim E. Phospholipase A₂ dependent release of fatty acids from peroxidized membranes. J Free Radic Biol Med 1985; 1: 263-271
29 Hemler ME, Cook HW, Lands WE M. Prostaglandin biosynthesis can be triggered by lipid peroxides. Arch Biochem Biophys 1979; 193: 340-355
30 Egan RW, Paxton J, Kuehl FA. Mechanism for irreversible selfdeactivation of prostaglandin synthetase. J Biol Chem 1976; 251: 7329-7335
31 Silk ST, Wong KT H, Marcus AJ. Arachidonic acid releasing activity in platelet membranes: Effects of sulfhydryl-modifying agents. Biochemistry 1981; 20: 391-397
32 Graff G, Gellerman JL, Sand DM, Schlenk H. Inhibition of blood platelet aggregation by dioxo-ene compounds. Biochim Biophys Acta 1984; 799: 143-150
33 Yamada K, Shuto K, Nakamizo N. Inhibition of platelet aggregation by a new agent, 2,2’-dithiobis-(N-2-hydroxypropylbernzamide) (KF4939). Thromb Res 1983; 29: 197-206
34 Yamada K, Shuto K, Kubo K, Nakamizo N. Evidence that KF4939, a new anti-platelet agent, inhibits phospholipase activation in rabbit platelets: Different aspects from cyclic AMP increasing agents and calmodulin antagonist. Arch int Pharmacodyn Ther 1984; 268: 141-154
35 Yamada K, Kubo K, Shuto K, Nakamizo N. Involvement of disulfide-sulfhydryl interaction in anti-platelet actions of KF4939. Thromb Res 1985; 38: 61-69
36 Lang J, Celotto C, Esterbauer H. Quantitative determination of the lipid peroxidation product 4-hydroxynonenal by high-performance liquid chromatography. Anal Biochem 1985; 150: 369-378