Bifrontale transkranielle Gleichstromstimulation zur Behandlung der Schizophrenie

Zusammenfassung

Gegenstand und Ziel: Die transkranielle Gleichstromstimulation (transcranial direct current stimulation, tDCS) wird als neues nicht invasives Hirnstimulationsverfahren für die Behandlung neurologischer und psychiatrischer Erkrankungen untersucht. Mittlerweile gibt es Fallberichte und eine randomisierte, kontrollierte Pilotstudie zur Behandlung akustischer Halluzinationen sowie der Negativsymptomatik bei Schizophrenie. Fallbericht: Im vorliegenden Fallbericht wurde ein Patient mit therapieresistenter Symptomatik bei paranoider Schizophrenie drei Wochen lang mit anodaler tDCS über dem linken dorsolateralen und kathodaler tDCS über dem rechten dorsolateralen Kortex behandelt. Ergebnisse: Es zeigte sich eine Verbesserung von Affektivität und Kognition, die Positivsymptome blieben jedoch nahezu unverändert. Klinische Relevanz: Die bifrontale tDCS stellt eine nebenwirkungsarme neue Behandlungsform dar und sollte in der Anwendung bei Erkrankungen aus dem schizophrenen Formenkreis weiter untersucht werden.

Summary

Objectives: In the recent years, transcranial direct current has been investigated in the treatment of neurologic and psychiatric disorders. Up to now there are several case reports and one randomized clinical trial on the treatment of auditory hallucinations and negative symptoms in schizophrenia. Case report: A patient with treatment resistant symptoms of a paranoid schizophrenia was treated with anodal tDCS applied to the left dorsolateral prefrontal cortex and cathodal tDCS applied to the right dorsolateral prefrontal cortex over three weeks. Results: There was an improvement of cognition and affect, whereas positive symptoms remained nearly unchanged. Clinical relevance: Bifrontal tDCS is associated with few side effects and merits further investigation in psychotic disorders.

Schlüsselwörter

Transkranielle Gleichstromstimulation - tDCS - Schizophrenie

Keywords

Transcranial direct current stimulation - tDCS - schizophrenia

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