Thromb Haemost 1999; 82(S 01): 64-67
DOI: 10.1055/s-0037-1615556
Commentaries
Schattauer GmbH

Vectorcardiography: A Tool for Non-invasive Detection of Reperfusion and Reocclusion?

Sven V. Eriksson
1   From the Department of Medicine, Danderyd Hospital, Danderyd, Sweden
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2017 (online)

Summary

In acute myocardial infarction, the perfusion status frequently fluctuates with rapid occurrences of coronary occlusion followed by myocardial ischemia. In patients with unstable angina, most episodes of ischemia are not accompanied by chest pain. In these patients it is important to be able to monitor the results of medical treatment non-invasively to establish the need for further intervention. It is not feasible to perform coronary angiography in all patients with acute myocardial infarction to evaluate patency of the infarct-related artery. Furthermore, even in a patent artery, no reflow may be present in the myocardial tissue. Angiography is therefore not the perfect golden standard to compare noninvasive ischemia monitoring with. Prognosis seems to be a better standard for comparison. This review indicates that vectorcardiography monitoring may identify myocardial reperfusion at an early stage and gives valuable prognostic information both in patients with unstable angina and acute myocardial infarction with low interobserver variability.

 
  • References

  • 1 The GUSTO Angiographic Investigators. The effect of tissue plasminogen activator streptokinase, or both on coronary artery patency, ventricular function and survival after acute myocardial infarction. N Engl J Med 1993; 329: 1615-22.
  • 2 Klootwijk P, Langer A, Meij S, Green C, Veldkamp RF, Ross AM, Armstrong PW, Simoons ML. Non-invasive prediction of reperfusion and coronary artery patency by continuous ST segment monitoring in the GUSTO-I trial. Eur Heart J 1996; 17: 689-98.
  • 3 Fernandez AR, Sequeira RF, Chakko S, Correa LF, de Marchena EJ, Chahine RA, Franceour DA, Myerburg RJ. ST segment tracking for rapid determination of patency of the infarct-related artery in acute myocardial infarction. J Am Coll Cardiol 1995; 26: 675-83.
  • 4 von Essen R, Schmidt W, Uebis R, Edelmann B, Effert S, Silny J, Rau G. Myocardial infarction and thrombolysis: electrocardiographic short term and long term results using precordial mapping. Br Heart J 1985; 54: 6-10.
  • 5 Saran RK, Been M, Furniss SS, Hawkins T, Reid DS. Reduction in ST segment elevation after thrombolysis predicts either coronary reperfusion or preservation of left ventricular function. Br Heart J 1990; 64: 113-7.
  • 6 Clemmensen P, Ohman EM, Sevilla DC, Peck S, Wagner NB, Quigley PS, Grande P, Lee KL, Wagner GS. Changes in standard electrocardiographic ST-segment elevation predictive of successful reperfusion in acute myocardial infarction. Am J Cardiol 1990; 66: 1407-11.
  • 7 Veldkamp RF, Green CL, Wilkons ML, Pope JE, Sawchak ST, Ryan JA, Califf RM, Wagner GS, Krucoff MW. for the Thrombolysis and Angio-plasty in Myocardial Infarction (TAMI) 7 study group. Comparison of continuos ST-segment recovery analysis with methods using static electrocardiograms for noninvasive patency assessment during acute myocardial infarction. Am J Cardiol 1994; 73: 1069-74.
  • 8 Gantz W, Geft Y, Shah PK, Lew AS, Rodrigues I, Weisss T. et al. Intravenous streptokinase in evolving acute myocardial infarction. Am J Cardiol 1984; 53: 1209-16.
  • 9 Hohnloser SH, Zabel M, Kasper W, Meinertz T, Just H. Assessment of coronary artery patency after thrombolytic therapy: accurate prediction utilizing the combined analysis of three noninvasive markers. J Am Coll Cardiol 1991; 18: 44-9.
  • 10 Kircher BJ, Topol EJ, O'Neill WW, Pitt B. Prediction of infarct coronary artery recanalization after intravenous thrombolytic therapy. Am J Cardiol 1987; 59: 513-5.
  • 11 Califf RM, O'Neill W, Stack R, et al. and the TAMI Study Group. Failure of simple clinical measurements to predict perfusion status after intravenous thrombolysis. Ann Int Med 1988; 108: 658-62.
  • 12 Abendschein DR, Ellis AK, Eisenberg PR, Klocke FJ, Sobel BE, Jaffe AS. Prompt detection of coronary recanalization by analysis of rates of change of concentrations of macromolecular markers in plasma. Coronary Artery Dis 1991; 2: 201-12.
  • 13 Laperche T, Golmard JL, Steg G. for the PERMN study group. Early behaviour of biochemical markers in patients with thrombolysis in myocardial infarction grade 2 flow in the infarct artery as opposed to other flow grades after intravenous thrombolysis for acute myocardial infarction. Am Heart J 1997; 134: 1044-55.
  • 14 Kenner MD, Zajac EJ, Kondos GT, Dave R, Winkelmann JW, Joftus J, Laucevicius A, Kybarskis A, Berukstis E, Urbonas A. et al. Ability of the no-reflow phenomenon during an acute myocardial infarction to predict left ventricular dysfunction at one-month follow-up. Am J Cardiol 1995; 76: 861-8.
  • 15 Bolognese L, Antoniucci D, Rovai D, Buonamici P, Cerisano G, Santoro GM, Marini C, L'Abbate A, Fazzini PF. Myocardial contrast echocardio-graphy versus dobutamine echocardiography for predicting functional recovery after acute myocardial infarction treated with primary coronary angioplasty. J Am Coll Cardiol 1996; 28: 1677-83.
  • 16 Mauri F, Maggioni AP, Franzosi MP. et al. A simple electrocardiographic predictor of the outcome of patients with acute myocardial infarction treated with a thrombolytic agent: a GISSI-2-derived analysis. J Am Coll Cardiol 1994; 24: 600-7.
  • 17 Van't Hof AW, Liem A, de Boer MJ, Zijlstra F. Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. Zwolle Myocardial infarction Study Group. Lancet 1997; 350: 615-9.
  • 18 Juliard JM, Himbert D, Golmard JL. et al. Can we provide reperfusion therapy to all unselected patients admitted with acute myocardial infarction?. J Am Coll Cardiol 1997; 30: 157-64.
  • 19 Hacket D, Davies G, Chierchia S, Maseri A. Intermittent coronary occlusion in acute myocardial infarction: value of combined thrombolytic and vaso-dilatory therapy. N Engl J Med 1987; 317: 1055-9.
  • 20 Davies GJ, Chierchia S, Maseri A. Prevention of myocardial infarction by very early treatment with intracoronary streptokinase. N Engl J Med 1984; 311: 1488-92.
  • 21 Ito H, Marauyama A, Iwakura K. et al. Clinical implications of the “no reflow” phenomenon. A predictor of complications and left ventricular remodelling in reperfused anterior wall myocardial infarction. Circulation 1996; 93: 223-38.
  • 22 Maes A, Van de Werf F, Nuyts J, Bormans G, Desmer W, Mortelmans L. Impairment of myocardial tissue perfusion early after successful thrombolysis: impact on myocardial flow, metabolism, and function at late follow-up. Circulation 1996; 92: 2072-8.
  • 23 Gustavsson G, Dellborg M, Lindahl B, Wallentin L. (on behalf of the BIOMACS Study Group) Dynamic vectorcardiography for early diagnosis of acute myocardial infarction compared with 12-lead electrocardiogram. Coron Artery Dis 196 7: 871-6.
  • 24 Eriksson P, Andersen K, Swedberg K, Dellborg M. Vectorcardiographic monitoring of patients with acute myocardial infarction and chronic bundle branch block. Eur Heart J 1997; 18: 1288-95.
  • 25 Naslund U, Haggmark S, Johansson G, Reiz S. Quantification of myocardium at risk and detection of reperfusion by dynamic vectorcardio-graphic ST segment monitoring in a pig occlusion-reperfusion model. Cardiovasc Res 1993; 27: 2170-8.
  • 26 Dellborg M, Topol EJ, Swedberg K. Dynamic QRS complex and ST segment vectorcardiographic monitoring can identify vessel patency in patients with acute myocardial infarction treated with reperfusion therapy. Am Heart J 1991; 122: 943-8.
  • 27 Dellborg M, Steg PG, Simoons M, Dietz R. et al. Vectorcardiographic monitoring to assess early vessel patency after reperfusion therapy for acute myocardial infarction. Eur Heart J 1995; 16: 21-9.
  • 28 Saran RK, Been M, Furniss SS, Hawkins T, Reid DS. Reduction in ST segment elevation after thrombolysis predicts either coronary reperfusion or preservation of left ventricular function. Br Heart J 1990; 64: 113-7.
  • 29 Schroder R, Dissmann R, Bruggemann T. Extent of early ST segment elevation resolution. A simple but strong predictor of outcome in patients with acute myocardial infarction. J Am Coll Cardiol 1994; 24: 384-91.
  • 30 Santoro GM, Antoniucci D, Valenti R, Bolognese L, Buonamici P, Trapani M, Boddi V, Fazzini PF. Rapid reduction of ST-segment elevation after successful direct angioplasty in acute myocardial infarction. Am J Cardiol 1997; 80: 685-9.
  • 31 Lundin P, Eriksson SV, Jensen J, Rehnqvist N. Ischemia monitoring with on-line vectorcardiography compared with results from a predischarge exercise test in patients with acute ischemic heart disease. J of Electro-cardiol 1995; 28: 277-85.
  • 32 Lundin P, Eriksson SV, Tornvall P, Andren B, Lindahl B, Melcher A. Ischemia monitoring with on-line vectorcardiography during dobutamine stress echocardiography in patients with unstable coronary artery disease. J Int Med 1998; 244: 61-70.
  • 33 Boden WE, O'Rourke RA, Crawford MH, Blaustein AS, Deedwania PC, Zoble RG, Wexler LF, Kleiger RE, Pepine CJ, Ferry DR, Chow BK, Lavori PW. Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy. Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH) Trial Investigators. N Engl J Med 1998; Jun 18 338 (25) 1785-92.
  • 34 McCullough PA, O'Neill WW, Graham M, Stomel RJ, Rogers F, David S, Farhat A, Kazlauskaite R, Al-Zagoum M, Grines CL. A prospective randomized trial of triage angiography in acute coronary syndromes in eligible for thrombolytic therapy. Results of the medicine versus angiography in thrombolytic exclusion (MATE) trial. J Am Coll Cardiol 1998; 32: 596-605.
  • 35 Madsen JK, Grande P, Saunamaki K, Thayssen P, Kassis E, Eriksen U, Rasmussen K, Haunso S, Nielsen TT, Haghfelt T, Fritz-Hansen P, Hjelms E, Paulsen PK, Alstrup P, Arendrup H, Niebuhr-Jorgensen U, Andersen LI. Danish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction. Circulation 1997; 96: 748-55.
  • 36 Dellborg M, Emanuelsson H, Riha M, Swedberg K. Dynamic QRS-complex and ST-segment monitoring by continuous vectorcardiography during coronary angioplasty. Coronary Artery Dis 1991; 2: 43-52.
  • 37 Jensen J, Eriksson SV, Lindvall B, Lundin P. On-line vectorcardiography during elective coronary angioplasty indicates procedure-related myocardial infarction. Cor Art Disease. in press.
  • 38 Lundin P, Eriksson SV, Fredriksson M, Rehnqvist N. Prognostic information from on-line vectorcardiography in patients with unstable angina pectoris. Cardiology 1995; 86: 60-6.
  • 39 Andersen K, Eriksson P, Dellborg M. Ischaemia detected by continuous online vectorcardiographic monitoring predicts unfavourable outcome in patients admitted with probable unstable coronary disease. Coron Artery Dis 1996; 7: 753-60.
  • 40 Andersen K, Eriksson P, Dellborg M. Non-invasive risk stratification within 48 h of hospital admission in patients with unstable coronary disease. Eur Heart J 1997; 18: 780-8.
  • 41 Lundin P, Eriksson SV, Strandberg L, Rehnqvist N. Prognostic Information from on-line vectorcardiography in acute myocardial infarction. Am J Cardiol 1994; 74: 1103-8.
  • 42 Lundin P, Jensen J, Eriksson SV. Reproducibility of on-line vectorcardiography measurements in patients with acute ischemic heart disease. J Int Med 1997; 242: 117-24.
  • 43 Kobayashi N, Ohmura N, Nakada I, Yasu T, Iwanaka H, Kubo N, Katsuki T, Fujii M, Yaginuma T, Saito M. Further ST elevation at reperfusion by direct percutaneous transluminal coronary angioplasty predicts poor recovery of left ventricular systolic function in anterior wall AMI. Am J Cardiol 1997; 79: 862-6.
  • 44 Somitsu Y, Nakamura M, Degawa T, Yamaguchi T. Prognostic value of slow resolution of ST-segment elevation following successful direct percutaneous transluminal coronary angioplasty for recovery of left ventricular function. Am J Cardiol 1997; 80: 406-10.
  • 45 Jensen SM, Johansson G, Osterman G, Reiz S, Naslund U. On-line computerized vectorangiography monitoring of myocardial ischemia during coronary angioplasty: comparison with 12-lead electrocardiography. Coronary Artery Dis 1994; 5: 507-14.
  • 46 Steg PG, Faraggi M, Himbert D, Juliard J-M, Coheen-Solal A, Lebtahi R, Gourgon R, Le Guludec D. Comparison using dynamic vectorcardiography and MIBI SPECT of ST-segment changes and myocardial MIBI uptake during percutaneous transluminal coronary angioplasty of the left anterior descending coronary artery. Am J Cardiol 1995; 75: 998-1002.