A Case Report of a Carbamazepine Overdose With Focus on Pharmacokinetic Aspects

N. Mittag; S. Meister; A. M. J. Berg; U. I. Walther

doi:10.1055/s-0035-1569268

Pharmacopsychiatry, Inhaltsverzeichnis

Pharmacopsychiatry 2016; 49(02): 76-78
DOI: 10.1055/s-0035-1569268

Original Paper

A Case Report of a Carbamazepine Overdose With Focus on Pharmacokinetic Aspects

Authors

N. Mittag

¹Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
S. Meister

²Department of Neurology, University of Rostock, Rostock, Germany
A. M. J. Berg

¹Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
U. I. Walther

¹Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany

Abstract

In this article a case of carbamazepine overdose is reported. It is common to use immuno-based methods in the field of therapeutic drug monitoring but it might be difficult to adapt such values to toxicological cases. For carbamazepine overdoses it is recommended also to determine the metabolite carbamazepine-10,11-epoxide. Especially for critical conditions a definite substance identification should be performed. In addition, quantifying main metabolites is recommended for an acute clinical toxicological assessment.

Key words

therapeutic drug monitoring - toxicological assessment

Volltext

Referenzen

References
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